Results 61 to 70 of about 67,468 (297)

Computer programs to assist in high resolution thermal denaturation and circular dichroism studies on nucleic acids [PDF]

Nucleic Acids Research, 1981
Computer programs are described that direct the collection, processing, and graphical display of numerical data obtained from high resolution thermal denaturation (1-3) and circular dichroism (4) studies. Besides these specific applications, the programs may also be useful, either directly or as programming models, in other types of spectrophotometric ...
T C, Goodman, S C, Hardies, C, Cortez, W, Hillen   +3 more
openaire   +2 more sources

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Use of Nucleic Acid Analogues in Diagnostics and Analytical Procedures [PDF]

, 2002
Methods of capture, recognition, detection, identification or quantitation of nucleic acids and diagnostics uses generally are described in which are used: (a) a peptide nucleic acid (PNA) comprising a polyamide backbone bearing a plurality of ligands at
Engholm, Michael, Berg, Rolf Henrik, Buchardt, Ole, Nielsen, Peter E.   +3 more
core  

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

THERMAL ANALYSIS OF POLYANION METACHROMASY: EFFECT OF TEMPERATURE ON METACHROMATIC SOLUTIONS OF NUCLEIC ACIDS AND ACID MUCOPOLYSACCHARIDES [PDF]

, 1969
Spectra of toluidine blue with acid mucopolysaccharides and nucleic acids were recorded over the temperature range 10-70°C. Metachromatic ratios were inverse, linear functions of temperature. Intercepts and slopes of the thermal plots distinguished acid
FRED ROTHSTEIN, JOHN W. KELLY, LOUIS CHANG   +2 more
core   +1 more source

Conformational changes in natural biopolymers induced by electromagnetic field and cadmium ion exposure

Russian Open Medical Journal, 2019
This research was aimed to study a combined influence of a low-intensity electromagnetic field (EMF) with 5-30 Hz frequency in presence of cadmium ions on structural changes in deoxyribonucleic acid (DNA) and human seralbumin (HSA).
Elena E. Tekutskaya
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Feasibility of microfluidic routes to monitor protein stability as a tool for bioprocessing [PDF]

, 2010
During the bioprocessing of therapeutics, proteins may become damaged leading to modifications and changes in stability. This may, as a consequence, cause serious and potentially fatal side effects when administered to patients making damage ...
Remtulla, N.
core  

Soni-removal of nucleic acids from inclusion bodies [PDF]

, 2014
Inclusion bodies (IBs) are commonly formed in Escherichia coli due to over expression of recombinant proteins in non-native state. Isolation, denaturation and refolding of these IBs is generally performed to obtain functional protein.
Neerathilingam, Muniasamy, Mysore, Sumukh, Gandham, Sai Hari A.   +2 more
core   +1 more source