Results 31 to 40 of about 5,589,910 (303)

CRISPR/Cas12a-Based Biosensing: Advances in Mechanisms and Applications for Nucleic Acid Detection. [PDF]

Biosensors (Basel)
Du K, Zeng Q, Jiang M, Hu Z, Zhou M, Xia K.   +5 more
europepmc   +2 more sources

Comparison of different samples for 2019 novel coronavirus detection by nucleic acid amplification tests

International Journal of Infectious Diseases, 2020
An ongoing outbreak of severe respiratory pneumonia associated with the 2019 novel coronavirus has recently emerged in China. Here we report the epidemiological, clinical, laboratory and radiological characteristics of 19 suspect cases.
Chunbao Xie, Lingxi Jiang, Guo Huang, Hong Pu, Bo Gong, He Lin, Shi Ma, Xuemei Chen, Bo Long, Guo Si, Hua Yu, Li Jiang, Xingxiang Yang, Yi Shi, Zhenglin Yang   +14 more
doaj   +1 more source

Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]

, 2011
Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Christina Troiber, Troiber, Christina, Wagner, Ernst, Ernst Wagner   +3 more
core   +1 more source

Analysis of Laboratory Proficiency Testing Results on the Detection of Porcine Parvovirus Nucleic Acid

Shiyan dongwu yu bijiao yixue, 2022
ObjectiveTo understand the testing level of the relevant laboratories and standardize the detection of porcine parvovirus (PPV) nucleic acid by implementing laboratory proficiency testing plan of the PPV nucleic acid testing.MethodsFrom January to August
LI Xiaobo, WANG Ji, WANG Hong, WANG Shujing, WANG Shasha, QIN Xiao, LI Wei, YUE Bingfei, FU Rui   +8 more
doaj   +1 more source

Design, synthesis, conformational analysis and nucleic acid hybridisation properties of thymidyl pyrrolidine-amide oligonucleotide mimics (POM) [PDF]

, 2003
Pyrrolidine-amide oligonucleotide mimics (POM) 1 were designed to be stereochemically and conformationally similar to natural nucleic acids, but with an oppositely charged, cationic backbone.
Tan, T. H. Samuel, Morral, Jordi, Tan, T.H.S., Morral-Cardoner, Jordi, Micklefield, Jason, Cooper, M.A., Hickman, D. T., Micklefield, J., Morral, J., King, Paul M., Hickman, David T., Cooper, Matthew A., King, P.M., Hickman, D.T., Samuel Tan, T. H.   +14 more
core   +1 more source

CRISPR-based nucleic acid diagnostics for pathogens [PDF]

, 2022
Pathogenic infections remain the primary threat for human health, especially the global COVID-19 pandemic. It is important to develop rapid, sensitive and multiplexed tools for detecting pathogens and their mutations, particularly the tailor-made ...
Yong, Zhang, Ruijie, Deng, Jinghong, Li, Hao, Yang, Xucong, Teng, Hongwei, Hou   +5 more
core   +1 more source

Research progress of triplex nucleic acid in food safety detection

Shipin yu jixie, 2022
This paper reviews the structure and stability of triplex nucleic acid, the progress of triplex nucleic acid-based fluorescence, electrochemical, colorimetric platform in detecting food borne hazards, and discusses the challenges and future development ...
SUN Hai-yan, LEI Yan-li, CHEN Wei-ju, QUNA Ke   +3 more
doaj   +1 more source

Miniaturized microfluidic-based nucleic acid analyzer to identify new biomarkers of biopsy lung cancer samples for subtyping

Frontiers in Chemistry, 2022
Identifying new biomarkers is necessary and important to diagnose and treat malignant lung cancer. However, existing protein marker detection methods usually require complex operation steps, leading to a lag time for diagnosis.
Xue Lin, Zi-Hao Bo, Wenqi Lv, Zhanping Zhou, Qin Huang, Wenli Du, Xiaohui Shan, Rongxin Fu, Xiangyu Jin, Han Yang, Ya Su, Kai Jiang, Yuchen Guo, Hongwu Wang, Hongwu Wang, Feng Xu, Guoliang Huang, Guoliang Huang   +17 more
doaj   +1 more source

Differential susceptibility of PCR reactions to inhibitors: an important and unrecognised phenomenon [PDF]

, 2008
PCR inhibition by nucleic acid extracts is a well known yet poorly described phenomenon. Inhibition assessment generally depends on the assumption that inhibitors affect all PCR reactions to the same extent; i.e.
Miller Robert F, Morris-Jones Stephen D, Tanya Novak, Garson Jeremy A, Jim F Huggett, Morris-Jones, SD, Zumla, A, Huggett, JF, Miller, RF, Green Clare, Zumla Alimuddin, Garson, JA, Novak Tanya, Novak, T, Jeremy A Garson, Clare Green, Stephen D Morris-Jones, Robert F Miller, Green, C, Huggett Jim F, Alimuddin Zumla   +20 more
core   +1 more source

Berberine, a Natural Compound That Demonstrates Antiviral Effects Against Ostreid Herpesvirus 1 Infection in Anadara broughtonii

Viruses
Ostreid herpesvirus 1 (OsHV-1) infection is the primary viral disease responsible for large-scale mortality in bivalve mollusks worldwide, and effective strategies to control the outbreaks of this disease are still lacking.
Hui-Gang Kang, Mao-Le Wei, Jing-Li Wang, Cui-Ping Ma, Xiang Zhang, Bo-Wen Huang, Lu-Sheng Xin, Chang-Ming Bai   +7 more
doaj   +1 more source