Results 31 to 40 of about 261,306 (113)

Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides [PDF]

, 2015
SummaryArgonaute proteins repress gene expression and defend against foreign nucleic acids using short RNAs or DNAs to specify the correct target RNA or DNA sequence.
Jolly, Samson M., Moore, Melissa J., Salomon, William E., Serebrov, Victor, Zamore, Phillip D.   +4 more
core   +1 more source

Towards combining backbone and sugar constraint in 3-3 bis-phosphonate tethered 2-4 bridged LNA oligonucleotide trimers. [PDF]

Therapeutic oligonucleotides are chemically modified to enhance their drug-like properties - including binding affinity for target RNA. Many nucleic acid analogs that enhance RNA binding affinity constrain the furanose sugar in an RNA-like sugar pucker ...
Duchamp, Edouard, Firoozi, Neda, Freestone, Graeme, Hanessian, Stephen, Oestergaard, Michael, Seth, Punit, Vasquez, Guillermo   +6 more
core   +1 more source

CARD In Situ hybridization: Sights and signals [PDF]

, 2018
During the last decade, several strategies have been developed to improve the detection sensitivity ofin situ hybridization (ISH) by amplification of either target nucleic acid sequences prior to ISH (e.g.,in situ PCR), or the detection signals after the
Komminoth, Paul, Speel, Ernst
core  

Real-time DNA microarray analysis [PDF]

, 2009
We present a quantification method for affinity-based DNA microarrays which is based on the real-time measurements of hybridization kinetics. This method, i.e.
Abdueva, Arjang Hassibi, Babak Hassibi, Bassil, Beissbarth, Belosludtsev, Berg, Bishop, Chee, Chen, Dai, Das, Fritz, Georgiadis, Ghosh, Hall, Hardenbol, Haris Vikalo, Hassibi, Hassibi, Hassibi, Heaton, Homola, Hubble, Huber, José Luis Riechmann, Kennedy, Lacowicz, Levine, Linneti, Lockhart, Lockhart, Marras, Okamura, Ota, Pease, Peterson, Rajendran, SantaLucia, Savran, Schena, Schena, Schienle, Shalon, Skvortsov, Smith, Steinfield, Stimpson, Su, Towery, Tu, Van Kampen, Vikalo, Wang, Watterson, Yamaguchi, Zeng   +56 more
core   +2 more sources

Origin of Information Encoding in Nucleic Acids through a Dissipation-Replication Relation [PDF]

Entropy 2020, 22(9), 940, 2018
Ultraviolet light incident on organic material can initiate its spontaneous dissipative structuring into chromophores which can then catalyze their own replication. This may have been the case for one of the most ancient of all chromophores dissipating the Archean UVC photon flux, the nucleic acids.
arxiv   +1 more source

PCR-Independent Detection of Bacterial Species-Specific 16S rRNA at 10 fM by a Pore-Blockage Sensor. [PDF]

, 2016
A PCR-free, optics-free device is used for the detection of Escherichia coli (E. coli) 16S rRNA at 10 fM, which corresponds to ~100-1000 colony forming units/mL (CFU/mL) depending on cellular rRNA levels.
Banda, Anisha, Esfandiari, Leyla, Kocharyan, Gayane, Lorenzini, Michael, Monbouquette, Harold G, Schmidt, Jacob J, Wang, Siqi, Wang, Siqing   +7 more
core   +1 more source

Using electropolymerization based doping for electro-addressable functionalization of a multi-electrode array probe for nucleic acid detection [PDF]

arXiv, 2017
Here, we report a facile method for electro-addressable functionalization of a probe comprising of closely spaced three individually addressable carbon fiber electrodes for detection of nucleic acids. First, a multi electrode array probe comprising three adjacent carbon fiber electrodes was fabricated through pulling a three-barrel glass capillary with
arxiv  

Halogen Bonding in Nucleic Acid Complexes [PDF]

, 2017
Halogen bonding (X-bonding) has attracted notable attention among noncovalent interactions. This highly directional attraction between a halogen atom and an electron donor has been exploited in knowledge-based drug design. A great deal of information has been gathered about X-bonds in protein-ligand complexes, as opposed to nucleic acid complexes. Here
arxiv   +1 more source

Fluorecently labeled bionanotransporters of nucleic acid based on carbon nanotubes [PDF]

Ukrainian Journal of Physics, 2009, Vol. 54, no. 1-2, pp. 207-215, 2012
Here we propose the approach to design of the new type of hybrids of oligonucleotides with fluorescein-functionalized single-walled carbon nanotubes. The approach is based on stacking interactions of functionalized nanotubes with pyrene residues in conjugates of oligonucleotides.
arxiv  

Molecular structure and interactions of nucleic acid components in nanopaticles: ab initio calculations [PDF]

Ukrainian Journal of Physics, 2012, Vol. 57, no. 7, pp. 723-731, 2012
Self-associates of nucleic acid components (stacking trimers and tetramers of the base pairs of nucleic acids) and short fragments of nucleic acids are nanoparticles (linear sizes of these particles are more than 10 A. Modern quantum-mechanical methods and softwares allow one to perform ab initio calculations of the systems consisting of 150-200 atoms ...
arxiv