Results 1 to 10 of about 437,756 (347)
Nitrogen heterocycles form peptide nucleic acid precursors in complex prebiotic mixtures [PDF]
Scientific Reports, 2019 The ability to store information is believed to have been crucial for the origin and evolution of life; however, little is known about the genetic polymers relevant to abiogenesis.
Laura E. Rodriguez +4 more
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Uptake of amino acids and nucleic acid precursors by regenerating rat liver [PDF]
Biochemical Journal, 1972 1. At 0.5–1.0h after partial hepatectomy the intracellular acid-soluble fraction of rat liver took up twice as much radioactivity from [3H]orotic acid, [3H]uridine and [3H]thymidine as did similar fractions from sham-operated animals. This increase in penetration was not prevented by adrenalectomy or actinomycin, both of which decreased precursor ...
Margery G. Ord, L. A. Stocken
semanticscholar +5 more sources
Selected Nucleic Acid Precursors in Studies of Aquatic Microbial Ecology [PDF]
Applied and Environmental Microbiology, 1982 The use of radiolabeled nucleosides and nucleic acid bases to estimate the rates of RNA and DNA synthesis in naturally occurring microbial assemblages requires numerous assumptions, several of which are evaluated herein. Comparative time series analyses of the uptake and incorporation, labeling specificity, and extent of catabolism of [2-
David M. Karl
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NUCLEIC ACID PRECURSORS AND PROTEIN SYNTHESIS [PDF]
Proceedings of the National Academy of Sciences, 1954 Arthur B. Pardee
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Polyamines and nucleic acid metabolism in chick embryo. Incorporation of labelled precursors into nucleic acids of subcellular fractions and polyribosomal patterns [PDF]
Biochemical Journal, 1968 1. An increase in polyamine concentration, caused by inhibiting the amine oxidase activities with iproniazid, increased the incorporation of [3H]orotic acid into chick-embryo RNA and DNA. On the other hand, a decrease in polyamine concentration, obtained by causing an increase in amine oxidase activities, decreased [3H]orotic acid incorporation into ...
G. Moruzzi +2 more
semanticscholar +5 more sources
An all-purine precursor of nucleic acids. [PDF]
Proceedings of the National Academy of Sciences, 1988 The theory is proposed that the pyrimidines in extant nucleic acids are postenzymatic substitutes for their isoelectronic and isogeometric position 3-bonded purine analogs xanthine and isoguanine, which were sibling products in a preenzymatic de novo purine pathway.
Günter Wächtershäuser
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EFFECTS OF NUCLEIC ACID PRECURSORS ON LIVER INJURIES
THE JOURNAL OF VITAMINOLOGY, 1967 AICA and AICA orotate were given in massive doses together with 20% casein diet to rats with liver injuries induced by a low protein, amino acid imbalanced diet, and the effects of both agents appraised.AICA orotate was apparently of value in recovering iodine numbers of fatty acids in liver lipids, increasing Palade granules and inhibiting fibrosis ...
Shuji Hashimoto
+6 more sources
A Second Pathway to Degrade Pyrimidine Nucleic Acid Precursors in Eukaryotes
Journal of Molecular Biology, 2008 Pyrimidine bases are the central precursors for RNA and DNA, and their intracellular pools are determined by de novo, salvage and catabolic pathways. In eukaryotes, degradation of uracil has been believed to proceed only via the reduction to dihydrouracil.
G. Andersen +13 more
openaire +4 more sources
Decoding Mycoplasma Nucleases: Biological Functions and Pathogenesis [PDF]
ToxinsNucleases are critical metabolic enzymes expressed by mycoplasmas to acquire nucleic acid precursors from the host for their parasitic existence. Certain nucleases, either membrane-bound or secreted, not only contribute to the growth of mycoplasmas but ...
Xinchao Yi +10 more
doaj +2 more sources
STUDIES ON PRECURSORS OF PYRIMIDINES OF NUCLEIC ACID
Journal of Biological Chemistry, 1954 Lawrence L. Weed, Darrell M. Wilson
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