Results 171 to 180 of about 191,094 (249)

Transient states during the annealing of mismatched and bulged oligonucleotides. [PDF]

Nucleic Acids Res
Todisco M, Ding D, Szostak JW.
europepmc   +1 more source

[24] Thermodynamics of ligand-nucleic acid interactions

Methods in Enzymology, 1992
Ligand-and protein-DNA equilibria are extremely sensitive to solution conditions (e.g., salt, temperature, and pH), and, in general, the effects of different solution variables are interdependent (i.e., linked). As a result, an assessment of the basis for the stability and specificity of ligand-or protein-DNA interactions requires quantitative studies ...
Timothy M. Lohman, David P. Mascotti
semanticscholar   +5 more sources

Statistical thermodynamics of nucleic acid melting transitions with coupled binding equilibria

Biopolymers, 1971
AbstractEquations are developed to describe the shift in the temperature of the helix–coil transition when small molecules bind to nucleic acids. Included are high polymers, oligonucleotides, and oligomer–polymer interactions. The equations prescribe simple ways of plotting experimental data to evaluate transition and binding parameters.
Donald M. Crothers
semanticscholar   +5 more sources

Thermodynamics and Kinetics‐Directed Regulation of Nucleic Acid‐Based Molecular Recognition

Small Methods
AbstractNucleic acid‐based molecular recognition plays crucial roles in various fields like biosensing and disease diagnostics. To achieve optimal detection and analysis, it is essential to regulate the response performance of nucleic acid probes or switches to match specific application requirements by regulating thermodynamics and kinetics properties.
Yihao Liu, Zihan Zhao, Yuqi Zeng, Minze He, Yifan Lyu, Quan Yuan   +5 more
semanticscholar   +4 more sources

Thermodynamics of Adsorption of Amino Acids, Small Peptides, and Nucleic Acid Components on Silica Adsorbents

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Vladimir A. Basiuk
semanticscholar   +4 more sources

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A Mathematical Model of Nucleic Acid Thermodynamics

2018
The DNA denaturation, the double-stranded DNA unwinding process, is a vital process for cells. The percentage of the denaturation is used as an index of organism complexity and it is the base of the DNA hybridisation technique, which provides a great deal of information.
Sonia Guarguagli, Franco Pastrone
openaire   +3 more sources

Thermodynamics of nucleic acids and their interactions with ligands

Quarterly Reviews of Biophysics, 2000
1. Introduction 2551.1 General thermodynamics 2562. Nucleic acid thermodynamics 2602.1 DNA duplexes 2612.2 RNA duplexes 2632.3 Hybrid DNA–RNA duplexes 2642.4 Hydration 2672.5 Conformational flexibility 2692.6 Thermodynamics 2723. Nucleic acid–ligand interactions 2773.1 Minor groove binders 2783.2 DNA intercalators 2843.3 Triple-helical systems 2883.3.1
Andrew N. Lane, Terence C. Jenkins
openalex   +4 more sources

lncRNATargets: A platform for lncRNA target prediction based on nucleic acid thermodynamics

Journal of Bioinformatics and Computational Biology, 2016
Many studies have supported that long noncoding RNAs (lncRNAs) perform various functions in various critical biological processes. Advanced experimental and computational technologies allow access to more information on lncRNAs. Determining the functions and action mechanisms of these RNAs on a large scale is urgently needed. We provided lncRNATargets,
Xiaobo Sun, Xiaobo Sun, Ruifeng Hu
openaire   +3 more sources

Atomistic Investigation of the Effect of Incremental Modification of Deoxyribose Sugars by Locked Nucleic Acid (β-d-LNA and α-l-LNA) Moieties on the Structures and Thermodynamics of DNA–RNA Hybrid Duplexes

Journal of Physical Chemistry B, 2014
Chemically modified oligonucleotides offer many possibilities in utilizing their special features for a vast number of applications in nucleic acid based therapies and synthetic molecular biology.
Suresh Gorle, U. Deva Priyakumar
openalex   +2 more sources