Results 181 to 190 of about 191,094 (249)

Native Characterization of Noncanonical Nucleic Acid Thermodynamics via Programmable Dynamic DNA Chemistry

Journal of the American Chemical Society
Folding thermodynamics, quantitatively described using parameters such as ΔGfold°, ΔHfold°, and ΔSfold°, is essential for characterizing the stability and functionality of noncanonical nucleic acid structures but remains difficult to measure at the ...
Yuqin Wu, Guan A. Wang, Qianfan Yang, Feng Li   +3 more
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Kinetic and Thermodynamic Origins of Osmolyte-Influenced Nucleic Acid Folding

The Journal of Physical Chemistry B, 2015
The influential role of monovalent and divalent metal cations in facilitating conformational transitions in both RNA and DNA has been a target of intense biophysical research efforts. However, organic neutrally charged cosolutes can also significantly alter nucleic acid conformational transitions.
David J. Nesbitt, Nicholas F. Dupuis, Erik D. Holmstrom   +2 more
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Hydrodynamics, Thermodynamics and Scattering Properties: Nucleic Acids, Nucleosomes and Chromatin

, 1985
Though the progress of both experimental and theoretical chemistry has been steady since the eighteenth century, it was only in our lifetime that the nature of the macromolecular state was clearly established. Until about fifty years ago it was generally believed that large, covalently bonded, well defined macromolecules do not exist, and only ill ...
Henryk Eisenberg
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Effects of Molecular Crowders on Single-Molecule Nucleic Acid Folding: Temperature-Dependent Studies Reveal True Crowding vs Enthalpic Interactions.

Journal of Physical Chemistry B, 2021
Biomolecular folding in cells can be strongly influenced by spatial overlap/excluded volume interactions (i.e., "crowding") with intracellular solutes.
Hsuan-Lei Sung, D. Nesbitt
semanticscholar   +1 more source

Cooperative activation of CRISPR-Cas12a based on optimization of nucleic acid hybridization kinetics and thermodynamics: More specific, flexible and controllable

Microchemical journal (Print)
Ziling Yang, Xiu‐Wu Bian
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Understanding the effect of locked nucleic acid and 2'-O-methyl modification on the hybridization thermodynamics of a miRNA-mRNA pair in the presence and absence of AfPiwi protein.

Biochemistry, 2014
miRNAs are some of the key epigenetic regulators of gene expression. They act through hybridization with their target mRNA and modulate the level of respective proteins via different mechanisms.
Santosh Kumar, K. Mapa, S. Maiti
semanticscholar   +1 more source

A Spectroscopic and Thermodynamic Study of Taxol Nucleic Acid Complexes

Nucleosides and Nucleotides, 1999
The interactions of natural and synthetic polynucleotide double strands with the antitumor agent paclitaxel and the oncological product "Taxol for Injection Concentrate" (abbreviated as taxol) were examined in diluted aqueous solutions by thermal denaturation profiles (Tm), CD spectra and UV-absorption measurements.
Ulrich Gromann, Siegfried Hoffmann, Stacy Tessler Lindau, Gerlinde Bischoff, Walter-Veselý Meister   +4 more
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Quantitative nucleic acids footprinting: thermodynamic and kinetic approaches

Current Opinion in Biotechnology, 1997
Quantitative footprinting techniques allow a detailed analysis of the thermodynamic forces that characterize nucleic acid-ligand interactions and ligand-induced changes in nucleic acid structure by separately resolving the intrinsic and cooperative Gibbs free energy changes describing the reactions being investigated.
Victoria Petri, Michael Brenowitz
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Thermodynamic database supports deciphering protein–nucleic acid interactions

Trends in Biotechnology, 2023
The thermodynamics of protein-nucleic acid interactions (PNIs) is crucial for elucidating the mechanisms of molecular recognition and pathological consequences. The Protein-Nucleic Acid Thermodynamics Database (PNATDB) is a database containing experimentally determined thermodynamic parameters along with sequence, structural, and function data, which ...
Long-Can Mei, Ge-Fei Hao, Guang-Fu Yang
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Thermodynamic databases for proteins and protein-nucleic acid interactions

Biopolymers, 2001
Thermodynamic data regarding proteins and their interactions are important for understanding the mechanisms of protein folding, protein stability, and molecular recognition. Although there are several structural databases available for proteins and their complexes with other molecules, databases for experimental thermodynamic data on protein stability ...
Ponraj Prabakaran, Jianghong An, Samuel Selvaraj, Akinori Sarai, M. Michael Gromiha, Hidetoshi Kono, Hatsuho Uedaira, Motohisa Oobatake   +7 more
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