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Quantitative nucleic acids footprinting: thermodynamic and kinetic approaches

Current Opinion in Biotechnology, 1997
Quantitative footprinting techniques allow a detailed analysis of the thermodynamic forces that characterize nucleic acid-ligand interactions and ligand-induced changes in nucleic acid structure by separately resolving the intrinsic and cooperative Gibbs free energy changes describing the reactions being investigated.
V, Petri, M, Brenowitz
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Comment on ‘Thermodynamic database supports deciphering protein–nucleic acid interactions’

Trends in Biotechnology, 2023
Mei and colleagues reported a thermodynamic database, PNATDB for protein-nucleic acid interactions, which contains 12 635 experimentally determined thermodynamic parameters. They claimed that extracting data from existing databases is difficult. ProNAB, which has more than 20 000 experimental data points for binding affinities of protein-nucleic acid ...
M. Michael Gromiha, Kannan Harini
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Thermodynamics of nucleic acids and their interactions with ligands

Quarterly Reviews of Biophysics, 2000
1. Introduction 2551.1 General thermodynamics 2562. Nucleic acid thermodynamics 2602.1 DNA duplexes 2612.2 RNA duplexes 2632.3 Hybrid DNA–RNA duplexes 2642.4 Hydration 2672.5 Conformational flexibility 2692.6 Thermodynamics 2723. Nucleic acid–ligand interactions 2773.1 Minor groove binders 2783.2 DNA intercalators 2843.3 Triple-helical systems 2883.3.1
A N, Lane, T C, Jenkins
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Thermodynamic databases for proteins and protein-nucleic acid interactions

Biopolymers, 2001
Thermodynamic data regarding proteins and their interactions are important for understanding the mechanisms of protein folding, protein stability, and molecular recognition. Although there are several structural databases available for proteins and their complexes with other molecules, databases for experimental thermodynamic data on protein stability ...
A, Sarai   +7 more
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Thermodynamic Characterization of Nucleic Acid Nanoparticles Hybridization by UV Melting

2023
The advances in nucleic acid nanotechnology have given rise to various elegantly designed structural complexes fabricated from DNA, RNA, chemically modified RNA strands, and their mixtures. The structural properties of NA nanoparticles (NANP) generally dictate and significantly impact biological function; and thus, it is critical to extract information
Megan, Teter   +3 more
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