Results 221 to 230 of about 79,150 (267)
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Comment on ‘Thermodynamic database supports deciphering protein–nucleic acid interactions’
Trends in Biotechnology, 2023Mei and colleagues reported a thermodynamic database, PNATDB for protein-nucleic acid interactions, which contains 12 635 experimentally determined thermodynamic parameters. They claimed that extracting data from existing databases is difficult. ProNAB, which has more than 20 000 experimental data points for binding affinities of protein-nucleic acid ...
M. Michael Gromiha, Kannan Harini
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Analyzing and predicting the thermodynamic effects of the metabolite trehalose on nucleic acids
Biopolymers, 2010AbstractThere is a lot of interest in exactly how nucleic acid duplexes are affected by the addition of certain stabilizing and destabilizing metabolites. Unfortunately, the differences in reaction conditions between published reports often precludes a comparison of the results, effectively preventing a cohesive strategy for predicting additive effects
Jonathan L. Hart +2 more
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Biopolymers, 2000
The dissociation and assembly of quadruplex DNA structures (and a few quadruplex RNAs) have been characterized at several levels of rigor, ranging from gross descriptions of factors that govern each process, to semiquantitative comparisons of the relative abilities of these factors to induce stabilization or destabilization, to quantitative studies of ...
Katie White +2 more
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The dissociation and assembly of quadruplex DNA structures (and a few quadruplex RNAs) have been characterized at several levels of rigor, ranging from gross descriptions of factors that govern each process, to semiquantitative comparisons of the relative abilities of these factors to induce stabilization or destabilization, to quantitative studies of ...
Katie White +2 more
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Thermodynamics and Kinetics of Nucleic Acids Folding
2023[spa] En este trabajo doctoral se han investigado las propiedades termodinámicas y cinéticas de los ácidos nucleicos. El principal objetivo era el estudio de los mecanismos de plegamiento que se llevan a cabo en la hibridación de moléculas de ADN y ARN y su caracterización energética. La tesis está organizada en cuatro partes principales. En la Parte I,
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Kinetic and Thermodynamic Origins of Osmolyte-Influenced Nucleic Acid Folding
The Journal of Physical Chemistry B, 2015The influential role of monovalent and divalent metal cations in facilitating conformational transitions in both RNA and DNA has been a target of intense biophysical research efforts. However, organic neutrally charged cosolutes can also significantly alter nucleic acid conformational transitions.
David J. Nesbitt +2 more
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Computer Methods and Programs in Biomedicine, 2013
Proper design of nucleic acid sequences is crucial for many applications. We have previously established a thermodynamics-based quantitative model to help design aptamer-based nucleic acid probes by predicting equilibrium concentrations of all interacting species.
Na Li, Jiaqi Zou
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Proper design of nucleic acid sequences is crucial for many applications. We have previously established a thermodynamics-based quantitative model to help design aptamer-based nucleic acid probes by predicting equilibrium concentrations of all interacting species.
Na Li, Jiaqi Zou
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lncRNATargets: A platform for lncRNA target prediction based on nucleic acid thermodynamics
Journal of Bioinformatics and Computational Biology, 2016Many studies have supported that long noncoding RNAs (lncRNAs) perform various functions in various critical biological processes. Advanced experimental and computational technologies allow access to more information on lncRNAs. Determining the functions and action mechanisms of these RNAs on a large scale is urgently needed. We provided lncRNATargets,
Xiaobo Sun, Xiaobo Sun, Ruifeng Hu
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Thermodynamics of Nucleic Acids Enclosed in Reverse Phase Vesicles
1984Reverse micelles and vesicles mimic properties of biological membranes in the sense that they include a small water volume in a charged or in an at least polar surface formed by the hydrophilic headgroups of amphiphilic compounds. Membranes with this type of a surface form the cellular compartments which are the reaction vessels for most chemical ...
Bernhard Brosius +3 more
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Thermodynamic Studies of Amsacrine Antitumor Agents with Nucleic Acids
1990The equilibrium binding of several anilinoacridine analogs are compared over a wide range of ionic strengths and temperatures. Although o-AMSA binds DNA with a higher affinity than m-AMSA it is not effective as an antitumor agent. Both m-AMSA and o-AMSA bind DNA in an intercalative manner.
R. M. Wadkins, D. E. Graves
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Thermodynamic studies on the interaction between nucleic acid and drug by calorimetry
Thermochimica Acta, 1985Abstract The heats of mixing of the DNA-AD, Duplex I-AD and Duplex II-one systems were measured at 298.15 ± 0.005 K by using an LKB batch type twin microcalorimeter with a help of spectral measurements. From the results of DNA-AD system obtained, the interaction between DNA and AD is mainly caused by intercalation manner by referring to the result of
K. Kano +2 more
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