Results 221 to 230 of about 221,973 (265)

Thermodynamic study of hybridization properties of heterochiral nucleic acids

Biochemical and Biophysical Research Communications, 2003
Heterochiral DNA and RNA heptamers, which contained an unnatural L-nucleotide, were synthesized, and thermodynamic analyses of their hybridization properties with complementary DNA and RNA strands were systematically conducted by UV melting experiments.
Hidehito, Urata, Hana, Shimizu, Hidekazu, Hiroaki, Daisuke, Kohda, Masao, Akagi   +4 more
openaire   +2 more sources

Selective Enrichment of Low‐Abundance DNA Variants Based on Programmable Peptide Nucleic Acid Probes

Chinese journal of chemistry
Single‐nucleotide variants (SNVs) are crucial in disease development, but their accurate detection is challenging due to their low abundance and interference from wild‐type targets.
Yi Zhang, Zhi Weng, Zixuan Huang, Qian Li, Chunhai Fan, Shihua Luo, Ping Song   +6 more
semanticscholar   +1 more source

Quantitative thermodynamic predication of interactions between nucleic acid and non-nucleic acid species using Microsoft excel

Computer Methods and Programs in Biomedicine, 2013
Proper design of nucleic acid sequences is crucial for many applications. We have previously established a thermodynamics-based quantitative model to help design aptamer-based nucleic acid probes by predicting equilibrium concentrations of all interacting species.
Jiaqi, Zou, Na, Li
openaire   +2 more sources

Thermodynamics and Kinetics of Nucleic Acid Association/Dissociation and Folding Processes

, 1999
Georg Plum, Kenneth J. Breslauer, Richard W. Roberts   +2 more
openalex   +2 more sources

A Spectroscopic and Thermodynamic Study of Taxol Nucleic Acid Complexes

Nucleosides and Nucleotides, 1999
The interactions of natural and synthetic polynucleotide double strands with the antitumor agent paclitaxel and the oncological product "Taxol for Injection Concentrate" (abbreviated as taxol) were examined in diluted aqueous solutions by thermal denaturation profiles (Tm), CD spectra and UV-absorption measurements.
G, Bischoff, U, Gromann, S, Lindau, W V, Meister, S, Hoffmann   +4 more
openaire   +2 more sources

Pyrene‐Modified Unlocked Nucleic Acids: Synthesis, Thermodynamic Studies, and Fluorescent Properties

ChemBioChem, 2012
AbstractTwo pyrene‐modified UNA monomers were synthesized and incorporated into 21‐mer DNA oligonucleotides. Melting temperatures and thermodynamic properties of the modified duplexes were measured, and the fluorescence properties of single strands and duplexes containing one or more pyrene‐UNA modifications were studied.
Karlsen, Kasper K, Pasternak, Anna, Jensen, Troels B, Wengel, Jesper   +3 more
openaire   +3 more sources

Synthesis and thermodynamics of peptide nucleic acid-conjugates

2023
Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Molecular Sciences, Faculty of Science Technology and Engineering, La Trobe University, Bundoora.
openaire   +1 more source

THERMODYNAMIC PROFILE OF INTERACTION OF PORPHYRINS WITH NUCLEIC ACIDS

2007
The binding of a number of novel water soluble porphyrins to nucleic acids (NA) were studied monitoring the changes in Soret region of absorbance spectra, fluorescence spectra and circular dichroism (CD) spectra of formed complexes. The binding modes for all complexes were dtermined. The binding isotherms were used to calculate the binding constant, Kb,
Samvel Haroutiunian, Yeva Dalyan, Ara Ghazaryan, Tigran Chalikian   +3 more
openaire   +1 more source

[Thermodynamic models of binding ligands to nucleic acids].

Biofizika, 2004
Models of adsorption were considered, which describe the binding of biologically active ligands on DNA templates. The binding is described most comprehensively and in greatest detail by the distribution function, which determines the probability of detecting the preset number of adsorbed ligands on the template.
Iu D, Nechipurenko, G V, Gurskii
openaire   +1 more source

Thermodynamic Studies of Amsacrine Antitumor Agents with Nucleic Acids

1990
The equilibrium binding of several anilinoacridine analogs are compared over a wide range of ionic strengths and temperatures. Although o-AMSA binds DNA with a higher affinity than m-AMSA it is not effective as an antitumor agent. Both m-AMSA and o-AMSA bind DNA in an intercalative manner.
D. E. Graves, R. M. Wadkins
openaire   +1 more source