Results 221 to 230 of about 215,794 (272)
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The Thermodynamic Basis of the Stability of Proteins, Nucleic Acids, and Membranes
1976Publisher Summary The contributions of the polar and nonpolar components of the proteins and nucleic acids can be regarded as constituting the bricks and mortar, respectively, of the two structures. This chapter describes the changes in enthalpy and entropy of reactions as diverse as denaturation, ligand binding, and self-association display a ...
James C. Osborne, Harold Edelhoch
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Comment on ‘Thermodynamic database supports deciphering protein–nucleic acid interactions’
Trends in Biotechnology, 2023Mei and colleagues reported a thermodynamic database, PNATDB for protein-nucleic acid interactions, which contains 12 635 experimentally determined thermodynamic parameters. They claimed that extracting data from existing databases is difficult. ProNAB, which has more than 20 000 experimental data points for binding affinities of protein-nucleic acid ...
M. Michael Gromiha, Kannan Harini
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Hydrodynamics, Thermodynamics and Scattering Properties: Nucleic Acids, Nucleosomes and Chromatin
, 1985 Though the progress of both experimental and theoretical chemistry has been steady since the eighteenth century, it was only in our lifetime that the nature of the macromolecular state was clearly established. Until about fifty years ago it was generally believed that large, covalently bonded, well defined macromolecules do not exist, and only ill ...
Henryk Eisenberg
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Journal of Physical Chemistry B, 2009
Thermodynamic studies of nucleic acids serve not only to widen our understanding on the nature and strength of forces that stabilize nucleic acids in a myriad of structural states they assume but also to facilitate the development of databases that could
Harleen Kaur +6 more
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Thermodynamic studies of nucleic acids serve not only to widen our understanding on the nature and strength of forces that stabilize nucleic acids in a myriad of structural states they assume but also to facilitate the development of databases that could
Harleen Kaur +6 more
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Biopolymers, 2000
The dissociation and assembly of quadruplex DNA structures (and a few quadruplex RNAs) have been characterized at several levels of rigor, ranging from gross descriptions of factors that govern each process, to semiquantitative comparisons of the relative abilities of these factors to induce stabilization or destabilization, to quantitative studies of ...
Katie White +2 more
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The dissociation and assembly of quadruplex DNA structures (and a few quadruplex RNAs) have been characterized at several levels of rigor, ranging from gross descriptions of factors that govern each process, to semiquantitative comparisons of the relative abilities of these factors to induce stabilization or destabilization, to quantitative studies of ...
Katie White +2 more
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Analyzing and predicting the thermodynamic effects of the metabolite trehalose on nucleic acids
Biopolymers, 2010AbstractThere is a lot of interest in exactly how nucleic acid duplexes are affected by the addition of certain stabilizing and destabilizing metabolites. Unfortunately, the differences in reaction conditions between published reports often precludes a comparison of the results, effectively preventing a cohesive strategy for predicting additive effects
Jonathan L. Hart +2 more
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Thermodynamics and Kinetics of Nucleic Acids Folding
2023[spa] En este trabajo doctoral se han investigado las propiedades termodinámicas y cinéticas de los ácidos nucleicos. El principal objetivo era el estudio de los mecanismos de plegamiento que se llevan a cabo en la hibridación de moléculas de ADN y ARN y su caracterización energética. La tesis está organizada en cuatro partes principales. En la Parte I,
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Computer Methods and Programs in Biomedicine, 2013
Proper design of nucleic acid sequences is crucial for many applications. We have previously established a thermodynamics-based quantitative model to help design aptamer-based nucleic acid probes by predicting equilibrium concentrations of all interacting species.
Na Li, Jiaqi Zou
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Proper design of nucleic acid sequences is crucial for many applications. We have previously established a thermodynamics-based quantitative model to help design aptamer-based nucleic acid probes by predicting equilibrium concentrations of all interacting species.
Na Li, Jiaqi Zou
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Thermodynamics of Nucleic Acids Enclosed in Reverse Phase Vesicles
1984Reverse micelles and vesicles mimic properties of biological membranes in the sense that they include a small water volume in a charged or in an at least polar surface formed by the hydrophilic headgroups of amphiphilic compounds. Membranes with this type of a surface form the cellular compartments which are the reaction vessels for most chemical ...
Bernhard Brosius +3 more
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Thermodynamic Studies of Amsacrine Antitumor Agents with Nucleic Acids
1990The equilibrium binding of several anilinoacridine analogs are compared over a wide range of ionic strengths and temperatures. Although o-AMSA binds DNA with a higher affinity than m-AMSA it is not effective as an antitumor agent. Both m-AMSA and o-AMSA bind DNA in an intercalative manner.
R. M. Wadkins, D. E. Graves
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