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Quantitative nucleic acids footprinting: thermodynamic and kinetic approaches
Current Opinion in Biotechnology, 1997Quantitative footprinting techniques allow a detailed analysis of the thermodynamic forces that characterize nucleic acid-ligand interactions and ligand-induced changes in nucleic acid structure by separately resolving the intrinsic and cooperative Gibbs free energy changes describing the reactions being investigated.
Victoria Petri, Michael Brenowitz
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Thermodynamic database supports deciphering protein–nucleic acid interactions
Trends in Biotechnology, 2023The thermodynamics of protein-nucleic acid interactions (PNIs) is crucial for elucidating the mechanisms of molecular recognition and pathological consequences. The Protein-Nucleic Acid Thermodynamics Database (PNATDB) is a database containing experimentally determined thermodynamic parameters along with sequence, structural, and function data, which ...
Long-Can Mei, Ge-Fei Hao, Guang-Fu Yang
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Thermodynamic databases for proteins and protein-nucleic acid interactions
Biopolymers, 2001Thermodynamic data regarding proteins and their interactions are important for understanding the mechanisms of protein folding, protein stability, and molecular recognition. Although there are several structural databases available for proteins and their complexes with other molecules, databases for experimental thermodynamic data on protein stability ...
Ponraj Prabakaran +7 more
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Thermodynamic study of hybridization properties of heterochiral nucleic acids
Biochemical and Biophysical Research Communications, 2003Heterochiral DNA and RNA heptamers, which contained an unnatural L-nucleotide, were synthesized, and thermodynamic analyses of their hybridization properties with complementary DNA and RNA strands were systematically conducted by UV melting experiments.
Hidehito Urata +4 more
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A Mathematical Model of Nucleic Acid Thermodynamics
2018The DNA denaturation, the double-stranded DNA unwinding process, is a vital process for cells. The percentage of the denaturation is used as an index of organism complexity and it is the base of the DNA hybridisation technique, which provides a great deal of information.
Sonia Guarguagli, Franco Pastrone
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Synthesis and thermodynamics of peptide nucleic acid-conjugates
2023Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Molecular Sciences, Faculty of Science Technology and Engineering, La Trobe University, Bundoora.
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Thermodynamic Characterization of Nucleic Acid Nanoparticles Hybridization by UV Melting
2023The advances in nucleic acid nanotechnology have given rise to various elegantly designed structural complexes fabricated from DNA, RNA, chemically modified RNA strands, and their mixtures. The structural properties of NA nanoparticles (NANP) generally dictate and significantly impact biological function; and thus, it is critical to extract information
Megan, Teter +3 more
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THERMODYNAMIC PROFILE OF INTERACTION OF PORPHYRINS WITH NUCLEIC ACIDS
2007The binding of a number of novel water soluble porphyrins to nucleic acids (NA) were studied monitoring the changes in Soret region of absorbance spectra, fluorescence spectra and circular dichroism (CD) spectra of formed complexes. The binding modes for all complexes were dtermined. The binding isotherms were used to calculate the binding constant, Kb,
Tigran V. Chalikian +3 more
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The Thermodynamic Basis of the Stability of Proteins, Nucleic Acids, and Membranes
1976Publisher Summary The contributions of the polar and nonpolar components of the proteins and nucleic acids can be regarded as constituting the bricks and mortar, respectively, of the two structures. This chapter describes the changes in enthalpy and entropy of reactions as diverse as denaturation, ligand binding, and self-association display a ...
James C. Osborne, Harold Edelhoch
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Comment on ‘Thermodynamic database supports deciphering protein–nucleic acid interactions’
Trends in Biotechnology, 2023Mei and colleagues reported a thermodynamic database, PNATDB for protein-nucleic acid interactions, which contains 12 635 experimentally determined thermodynamic parameters. They claimed that extracting data from existing databases is difficult. ProNAB, which has more than 20 000 experimental data points for binding affinities of protein-nucleic acid ...
M. Michael Gromiha, Kannan Harini
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