Results 1 to 10 of about 6,062,195 (387)
Cytoplasmic Mechanisms of Recognition and Defense of Microbial Nucleic Acids.
Annual Review of Cell and Developmental Biology, 2018 Microbial nucleic acids are major signatures of invading pathogens, and their recognition by various host pattern recognition receptors (PRRs) represents the first step toward an efficient innate immune response to clear the pathogens.
Ming-Ming Hu, H. Shu
semanticscholar +1 more source
Nucleic acids and analogs for bone regeneration
Bone Research, 2018 With the incidence of different bone diseases increasing, effective therapies are needed that coordinate a combination of various technologies and biological materials.
Yuxin Zhang +7 more
semanticscholar +1 more source
Exploring RNA modifications in infectious non-coding circular RNAs
RNA BiologyViroids, small circular non-coding RNAs, act as infectious pathogens in higher plants, demonstrating high stability despite consisting solely of naked RNA.
Pavel Vopalensky +8 more
doaj +1 more source
Communications Chemistry, 2022 Controlled enzymatic DNA synthesis represents an alternative synthetic methodology that circumvents the limitations of traditional soild-phase synthesis. Here, the authors explore the use of 3’-phosphate as a transient protecting group for the controlled
Marie Flamme +5 more
doaj +1 more source
Mechanisms of HIV-1 Nucleocapsid Protein Inhibition by Lysyl-Peptidyl-Anthraquinone Conjugates [PDF]
, 2016 The Nucleocapsid protein NCp7 (NC) is a nucleic acid chaperone responsible for essential steps of the HIV-1 life cycle and an attractive candidate for drug development.
Alice Sosic +12 more
core +2 more sources
Current Opinion in Structural Biology, 1992 Abstract Bulges are important structural elements in RNA and DNA. Progress has been made in defining the sequence dependence of the structure and stability of bulges; however, the molecular interactions responsible for these sequence effects are not yet completely understood.
openaire +2 more sources
Silencing disease genes in the laboratory and the clinic
, 2011 Synthetic nucleic acids are commonly used laboratory tools for modulating gene expression and have the potential to be widely used in the clinic. Progress towards nucleic acid drugs, however, has been slow and many challenges remain to be overcome before
Corey, David R., Watts, Jonathan K.
core +1 more source
eLife, 2017 Transcription start-site (TSS) selection and alternative promoter (AP) usage contribute to gene expression complexity but little is known about their impact on translation.
Ana Tamarkin-Ben-Harush +4 more
doaj +1 more source
Nucleic acids and protein synthesis in cancer cell mitochondria. I. Nucleic acids in rat hepatoma mitochondria [PDF]
, 1967 The contents of nucleic acids in rat liver and hepatoma mitochondria and the physico-chemical properties on DNA's isolated from these mitochondria were comparatively investigated. The results are briefly summarized as follows. 1.
Inaba, Kozo
core +1 more source
Inverted and mirror repeats in model nucleotide sequences [PDF]
, 2007 We analytically and numerically study the probabilistic properties of inverted and mirror repeats in model sequences of nucleic acids. We consider both perfect and non-perfect repeats, i.e. repeats with mismatches and gaps. The considered sequence models
Fabrizio Lillo +3 more
core +2 more sources