Results 1 to 10 of about 1,078,683 (343)
G-quadruplex formation at human DAT1 gene promoter: Effect of cytosine methylation
Biochemistry and Biophysics Reports, 2023 The dopamine transporter gene (DAT1), a recognized genetic risk factor for attention deficit hyperactivity disorder (ADHD) is principally responsible for the regulation of dopamine synaptic levels and serves as a key target in many psychostimulants drugs.
Nishu Nain +3 more
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Tellurium-Modified Nucleosides, Nucleotides, and Nucleic Acids with Potential Applications
Molecules, 2022 Tellurium was successfully incorporated into proteins and applied to protein structure determination through X-ray crystallography. However, studies on tellurium modification of DNA and RNA are limited. This review highlights the recent development of Te-
Cen Chen, Zhen Huang
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Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation [PDF]
, 2020 Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1.
De Munck, Jolien +12 more
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The smfBox is an open-source platform for single-molecule FRET
Nature Communications, 2020 Broad uptake of smFRET has been hindered by high instrument costs and a lack of open-source hardware and acquisition software. Here, the authors present the smfBox, a cost-effective open-source platform capable of measuring precise FRET efficiencies ...
Benjamin Ambrose +10 more
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Molecules, 2022 Oligonucleotide tools, as modulators of alternative splicing, have been extensively studied, giving a rise to new therapeutic approaches. In this article, we report detailed research on the optimization of bifunctional antisense oligonucleotides (BASOs),
Natalia Bartyś +2 more
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Pharmaceuticals, 2021 Aptamers constitute an answer for the growing need for targeted therapy development. One of the most well-known representatives of this group of compounds is thrombin binding aptamers (TBA) targeted towards thrombin.
Weronika Kotkowiak +2 more
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Deciphering the tRNA-derived small RNAs: origin, development, and future
Cell Death and Disease, 2021 Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a novel category of small noncoding RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the roles of tsRNAs in the development of human diseases.
Bowen Liu +5 more
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A bouquet of DNA structures: Emerging diversity
Biochemistry and Biophysics Reports, 2016 Structural polymorphism of DNA has constantly been evolving from the time of illustration of the double helical model of DNA by Watson and Crick. A variety of non-canonical DNA structures have constantly been documented across the globe.
Mahima Kaushik +8 more
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An ultrasensitive photoelectrochemical nucleic acid biosensor [PDF]
, 2005 A simple and ultrasensitive procedure for non-labeling detection of nucleic acids is described in this study. It is based on the photoelectrochemical detection of target nucleic acids by forming a nucleic acid/photoreporter adduct layer on an ITO ...
Gao, Zhiqiang, Tansil, Natalia C.
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Self-association of Coralyne: An ordered thermal destacking
Results in Chemistry, 2020 Understanding DNA-ligand interactions is a prerequisite, for designing sequence/structure specific ligands. Generally, stabilization/destabilization of DNA structures as a function of ligand is studied using UV-thermal melting, and the data is usually ...
Shikha Kaushik +3 more
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