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Science China Chemistry, 2020 Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things. The analysis of nucleic acids and nucleic acids-based analysis have been widely applied in biological studies, clinical diagnosis, environmental analysis ...
Yongxi Zhao +43 more
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Tellurium-Modified Nucleosides, Nucleotides, and Nucleic Acids with Potential Applications
Molecules, 2022 Tellurium was successfully incorporated into proteins and applied to protein structure determination through X-ray crystallography. However, studies on tellurium modification of DNA and RNA are limited. This review highlights the recent development of Te-
Cen Chen, Zhen Huang
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A Hitchhiker's Guide to Click-Chemistry with Nucleic Acids.
Chemical Reviews, 2021 Click chemistry is an immensely powerful technique for the fast and efficient covalent conjugation of molecular entities. Its broad scope has positively impacted on multiple scientific disciplines, and its implementation within the nucleic acid field has
N. Z. Fantoni, A. El-Sagheer, T. Brown
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Pharmaceuticals, 2021 Aptamers constitute an answer for the growing need for targeted therapy development. One of the most well-known representatives of this group of compounds is thrombin binding aptamers (TBA) targeted towards thrombin.
Weronika Kotkowiak +2 more
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Molecules, 2022 Oligonucleotide tools, as modulators of alternative splicing, have been extensively studied, giving a rise to new therapeutic approaches. In this article, we report detailed research on the optimization of bifunctional antisense oligonucleotides (BASOs),
Natalia Bartyś +2 more
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Chemical Science, 2021 Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated (Cas) protein systems have transformed the field of genome editing and transcriptional modulation.
Wei Feng +11 more
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Deciphering the tRNA-derived small RNAs: origin, development, and future
Cell Death and Disease, 2021 Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a novel category of small noncoding RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the roles of tsRNAs in the development of human diseases.
Bowen Liu +5 more
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The smfBox is an open-source platform for single-molecule FRET
Nature Communications, 2020 Broad uptake of smFRET has been hindered by high instrument costs and a lack of open-source hardware and acquisition software. Here, the authors present the smfBox, a cost-effective open-source platform capable of measuring precise FRET efficiencies ...
Benjamin Ambrose +10 more
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