Results 1 to 10 of about 64,715 (174)
Tellurium-Modified Nucleosides, Nucleotides, and Nucleic Acids with Potential Applications
Molecules, 2022 Tellurium was successfully incorporated into proteins and applied to protein structure determination through X-ray crystallography. However, studies on tellurium modification of DNA and RNA are limited. This review highlights the recent development of Te-
Cen Chen, Zhen Huang
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Molecules, 2022 Oligonucleotide tools, as modulators of alternative splicing, have been extensively studied, giving a rise to new therapeutic approaches. In this article, we report detailed research on the optimization of bifunctional antisense oligonucleotides (BASOs),
Natalia Bartyś +2 more
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Pharmaceuticals, 2021 Aptamers constitute an answer for the growing need for targeted therapy development. One of the most well-known representatives of this group of compounds is thrombin binding aptamers (TBA) targeted towards thrombin.
Weronika Kotkowiak +2 more
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Deciphering the tRNA-derived small RNAs: origin, development, and future
Cell Death and Disease, 2021 Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a novel category of small noncoding RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the roles of tsRNAs in the development of human diseases.
Bowen Liu +5 more
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The smfBox is an open-source platform for single-molecule FRET
Nature Communications, 2020 Broad uptake of smFRET has been hindered by high instrument costs and a lack of open-source hardware and acquisition software. Here, the authors present the smfBox, a cost-effective open-source platform capable of measuring precise FRET efficiencies ...
Benjamin Ambrose +10 more
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A bouquet of DNA structures: Emerging diversity
Biochemistry and Biophysics Reports, 2016 Structural polymorphism of DNA has constantly been evolving from the time of illustration of the double helical model of DNA by Watson and Crick. A variety of non-canonical DNA structures have constantly been documented across the globe.
Mahima Kaushik +8 more
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Dual miRNases for Triple Incision of miRNA Target: Design Concept and Catalytic Performance
Molecules, 2020 Irreversible destruction of disease-associated regulatory RNA sequences offers exciting opportunities for safe and powerful therapeutic interventions against human pathophysiology.
Olga Patutina +6 more
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Molecules, 2021 Modified 2′-deoxyribonucleotide triphosphates (dNTPs) have widespread applications in both existing and emerging biomolecular technologies. For such applications it is an essential requirement that the modified dNTPs be substrates for DNA polymerases. To
Claire Dutson +5 more
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Current Opinion in Structural Biology, 2012 Nucleic acids are an important class of biological macromolecules that carry out a variety of cellular roles. For many functions, naturally occurring DNA and RNA molecules need to fold into precise three-dimensional structures. Due to their self-assembling characteristics, nucleic acids have also been widely studied in the field of nanotechnology, and ...
Sim, A, Minary, P, Levitt, M
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Science China Chemistry, 2020 Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things. The analysis of nucleic acids and nucleic acids-based analysis have been widely applied in biological studies, clinical diagnosis, environmental analysis ...
Zai-Sheng Wu +45 more
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