Results 101 to 110 of about 449,751 (323)
Delivery of Nucleic Acids [PDF]
Pharmaceutical Research, 2007 Wim E. Hennink +2 more
openaire +4 more sources
, 2017 Organisms throughout biology need to maintain the integrity of their genome. From bacteria to vertebrates, life has established sophisticated mechanisms to detect and eliminate foreign genetic material or to restrict its function and replication. Tremendous progress has been made in the understanding of these mechanisms which keep foreign or unwanted ...
openaire +2 more sources
Artificial Receptor in Synthetic Cells Performs Transmembrane Activation of Proteolysis
Advanced Biology, EarlyView.Transmembrane signaling is the hallmark of living cells and is among the highest challenges for the design of synthetic cells. Herein, an artificial receptor based on the chemistry of self‐immolative linkers is used to communicate information across the lipid bilayer, for transmembrane activation of enzymatic activity. Abstract The design of artificial,
Ane Bretschneider Søgaard +7 more
wiley +1 more source
Structural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif
Nature Communications, 2018 The DIR2s RNA aptamer activates the fluorescence of cyanine dyes allowing detection of two well-resolved emission colors. Here authors solve the crystal structures of the apo and OTB-SO3 fluorophore-bound DIR2s and show how the fluorophore ligand is ...
Sandip A. Shelke +11 more
doaj +1 more source
Intracellular Amounts of Nucleic Acids and Protein During Pollen Grain Growth in Tradescantia [PDF]
, 1958 John Woodard
openalex +1 more source
Advanced Biology, EarlyView.Coacervation driven by liquid‐liquid phase separation (LLPS) of biopolymers has garnered increasing attention in biology since this leads to the formation of membraneless organelles capable of performing essential yet largely unknown functions. This review highlights recent advances in coacervates (artificial condensates) composed of low‐molecular ...
Sayuri L. Higashi, Masato Ikeda
wiley +1 more source
Theoretical models for single-molecule DNA and RNA experiments: from elasticity to unzipping [PDF]
arXiv, 2002 We review statistical-mechanical theories of single-molecule micromanipulation experiments on nucleic acids. First, models for describing polymer elasticity are introduced. We then review how these models are used to interpret single-molecule force-extension experiments on single-stranded and double-stranded DNA.
arxiv
Induction of Division through Nucleic Acid Treatment [PDF]
, 1954 Arun Kumar Sharma, Sudip Sen
openalex +1 more source
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source
In utero nanoparticle delivery for site-specific genome editing
Nature Communications, 2018 The correction of genetic defects in utero could allow for improved outcomes of gene therapy. Here, the authors demonstrate safe delivery of nanoparticles to fetal mouse tissues, and show that nanoparticles containing peptide nucleic acids to edit the ...
Adele S. Ricciardi +15 more
doaj +1 more source