Results 11 to 20 of about 6,062,195 (387)

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation [PDF]

bioRxiv, 2020
Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1.
De Munck, Jolien, de Reuver, Richard, Declercq, Wim, Devos, Michael, Dierick, Evelien, Gilbert, Barbara, Lefebvre, Sylvie, Maelfait, Jonathan, Nemegeer, Josephine, Rehwinkel, Jan, Tanghe, Giel, Vandenabeele, Peter, Verheirstraeten, Maud   +12 more
core   +3 more sources

Nucleic Acids Analysis [PDF]

Science China Chemistry, 2020
Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things.
Yongxi Zhao, Xiaolei Zuo, Qian Li, Feng Chen, Yan-Ru Chen, Jinqi Deng, Da Han, Changlong Hao, Fujian Huang, Yanyi Huang, Guoliang Ke, Hua Kuang, Fan Li, Jiang Li, Min Li, Na Li, Zhenyu Lin, Dingbin Liu, Juewen Liu, Libing Liu, Xiaoguo Liu, Chunhua Lu, Fang Luo, Xiuhai Mao, Jiashu Sun, B. Tang, Fei Wang, Jianbin Wang, Lihua Wang, Shu Wang, Lingling Wu, Zai‐Sheng Wu, Fan Xia, Chuanlai Xu, Yang Yang, Bifeng Yuan, Quan Yuan, Chao Zhang, Zhi Zhu, C. Yang, Xiaobing Zhang, Huanghao Yang, W. Tan, C. Fan   +43 more
semanticscholar   +3 more sources

On yeast nucleic acid [PDF]

Experimental Biology and Medicine, 1910
On hydrolysis of yeast nucleic acid the following components had been maintained: adenin, guanin, cytosin, uracil, dribose and phosphoric acid. On the basis of this knowledge and on the basis of the results of the elementary composition of the acid, the composition of the yeast nucleic acid was expressed schematically in the following manner:
P.A. Levene, W. A. Jacobs
openalex   +4 more sources

Nucleic Acids

Annual Review of Biochemistry, 1954
Kiyosi Ogawa
openalex   +4 more sources

G-quadruplex formation at human DAT1 gene promoter: Effect of cytosine methylation

Biochemistry and Biophysics Reports, 2023
The dopamine transporter gene (DAT1), a recognized genetic risk factor for attention deficit hyperactivity disorder (ADHD) is principally responsible for the regulation of dopamine synaptic levels and serves as a key target in many psychostimulants drugs.
Nishu Nain, Anju Singh, Shoaib Khan, Shrikant Kukreti   +3 more
doaj   +1 more source

Tellurium-Modified Nucleosides, Nucleotides, and Nucleic Acids with Potential Applications

Molecules, 2022
Tellurium was successfully incorporated into proteins and applied to protein structure determination through X-ray crystallography. However, studies on tellurium modification of DNA and RNA are limited. This review highlights the recent development of Te-
Cen Chen, Zhen Huang
doaj   +1 more source

A Hitchhiker's Guide to Click-Chemistry with Nucleic Acids.

Chemical Reviews, 2021
Click chemistry is an immensely powerful technique for the fast and efficient covalent conjugation of molecular entities. Its broad scope has positively impacted on multiple scientific disciplines, and its implementation within the nucleic acid field has
N. Z. Fantoni, A. El-Sagheer, T. Brown
semanticscholar   +1 more source

CRISPR technology incorporating amplification strategies: molecular assays for nucleic acids, proteins, and small molecules†

Chemical Science, 2021
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated (Cas) protein systems have transformed the field of genome editing and transcriptional modulation.
Wei Feng, Ashley M Newbigging, Jeffrey Tao, Yiren Cao, Hanyong Peng, Connie Le, Jinjun Wu, B. Pang, Juan Li, D. Tyrrell, Hongquan Zhang, X. Le   +11 more
semanticscholar   +1 more source

Optimization of Bifunctional Antisense Oligonucleotides for Regulation of Mutually Exclusive Alternative Splicing of PKM Gene

Molecules, 2022
Oligonucleotide tools, as modulators of alternative splicing, have been extensively studied, giving a rise to new therapeutic approaches. In this article, we report detailed research on the optimization of bifunctional antisense oligonucleotides (BASOs),
Natalia Bartyś, Anna Pasternak, Jolanta Lisowiec-Wąchnicka   +2 more
doaj   +1 more source

A Comprehensive Analysis of the Thrombin Binding Aptamer Containing Functionalized Pyrrolo-2’-deoxycytidines

Pharmaceuticals, 2021
Aptamers constitute an answer for the growing need for targeted therapy development. One of the most well-known representatives of this group of compounds is thrombin binding aptamers (TBA) targeted towards thrombin.
Weronika Kotkowiak, Zofia Jahnz-Wechmann, Anna Pasternak   +2 more
doaj   +1 more source