Results 21 to 30 of about 1,078,683 (343)

DNA Renaturation at the Water-Phenol Interface [PDF]

, 2003
We study DNA adsorption and renaturation in a water-phenol two-phase system, with or without shaking. In very dilute solutions, single-stranded DNA is adsorbed at the interface in a salt-dependent manner.
121, 125, 23, 262, 27, 276, 28, 289, 35, 376, 38, 381, 395, 41, 52, 56, 7, 740, 77, 82, 90, 90, 98, 98, Alberts, Anderson, Anderson, Belhachemi, Berg, Berg, Bernal, Brahms, Braun, Campell, Carri, Carrington, Cech, Chan, Chaperon, Chomczynski, Chow, Christiansen, Craig, Davis, Deamer, DiMarzio, Duckett, Eigen, Eigen, Eisenberg, Escara, Felsenfeld, Fleming, Gennes, Gierer, Gilbert, Gold, Grassmann, Grosberg, Hagenmuller, Hammes, Hearst, Hegner, Helmer, Herschlag, Herskovits, Hill, Jaeger, Joanicot, Joyce, Joyce, Joyce, Katcher, Kauzmann, Kirby, Kirby, Kirby, Kohne, Kowalczykowski, Lahav, Lang, Laurent, Lennard-Jones, Leo, Lerman, Levine, Lohman, Ma, Maier, Maier, Mandell, Manning, Marmur, Marmur, Massie, Meijering, Meuthen, Miller, Morimatsu, Nadassi, Nandi, Neidle, Noller, Oparin, Pace, Pace, Paecht-Horowitz, Papafil, Pelta, Perutz, Piechowska, Piechowska, Pontius, Prigogine, Pusztai, Pörschke, Rhodes, Richter, Riggs, Robertson, Rothman, Saenger, Saito, Saxinger, Schaper, Schürmann, Sevag, Sikorav, Singer, Sinsheimer, Skinner, Smith, Smoluchowski, Studier, Studier, Szostak, Tabor, Tikhonenko, Timmermans, Tor, Tsang, Tsuchihashi, Ts’o, Ts’o, Vesnaver, Wagner, Wang, Ward, Weinstock, Westhof, Wetmur, Wetmur, Widom, Wieder, Winter, Woese, Wolfe, Zaks, Zaks, Zasloff, Zhulina, Ölçer   +161 more
core   +3 more sources

Lipid and Peptide-Oligonucleotide Conjugates for Therapeutic Purposes: From Simple Hybrids to Complex Multifunctional Assemblies

Pharmaceutics, 2023
Antisense and small interfering RNA (siRNA) oligonucleotides have been recognized as powerful therapeutic compounds for targeting mRNAs and inducing their degradation. However, a major obstacle is that unmodified oligonucleotides are not readily taken up
Carme Fàbrega, Anna Aviñó, Natalia Navarro, Andreia F. Jorge, Santiago Grijalvo, Ramon Eritja   +5 more
doaj   +1 more source

Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]

, 2011
Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Troiber, Christina, Wagner, Ernst
core   +1 more source

Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model

Frontiers in Pharmacology, 2019
Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases ...
Olga A. Patutina, Svetlana K. Miroshnichenko, Nadezhda L. Mironova, Aleksandra V. Sen’kova, Elena V. Bichenkova, David J. Clarke, Valentin V. Vlassov, Marina A. Zenkova   +7 more
doaj   +1 more source

Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences

Molecules, 2021
RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are currently ...
Yaroslav Staroseletz, Svetlana Gaponova, Olga Patutina, Elena Bichenkova, Bahareh Amirloo, Thomas Heyman, Daria Chiglintseva, Marina Zenkova   +7 more
doaj   +1 more source

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. [PDF]

, 2008
Mammalian Toll-like receptors (TLRs) 3, 7, 8 and 9 initiate immune responses to infection by recognizing microbial nucleic acids; however, these responses come at the cost of potential autoimmunity owing to inappropriate recognition of self nucleic acids.
Barton, Gregory M, Chapman, Harold A, Ewald, Sarah E, Lau, Laura, Lee, Bettina L, Shi, Guo-Ping, Wickliffe, Katherine E   +6 more
core   +2 more sources

Atomic Structures of Molecules Based on Additivity of Atomic and/or Ionic Radii [PDF]

, 2009
The authors have shown in recent years that interatomic and interionic distances are sums of the radii of the adjacent atoms and/or ions. Many examples will be provided and it will be shown how the experimental bond lengths agree with the radii sums. The
Raji Heyrovska, Sara Narayan
core   +2 more sources

Enhanced Hybridization Selectivity Using Structured GammaPNA Probes

Molecules, 2020
High affinity nucleic acid analogues such as gammaPNA (γPNA) are capable of invading stable secondary and tertiary structures in DNA and RNA targets but are susceptible to off-target binding to mismatch-containing sequences.
Taylor D. Canady, April S. Berlyoung, Joe A. Martinez, Cole Emanuelson, Cheryl A. Telmer, Marcel P. Bruchez, Bruce A. Armitage   +6 more
doaj   +1 more source

Ultrashort Peptide Self-Assembly: Front-Runners to Transport Drug and Gene Cargos

Frontiers in Bioengineering and Biotechnology, 2020
The translational therapies to promote interaction between cell and signal come with stringent eligibility criteria. The chemically defined, hierarchically organized, and simpler yet blessed with robust intermolecular association, the peptides, are ...
Seema Gupta, Indu Singh, Indu Singh, Ashwani K. Sharma, Pradeep Kumar   +4 more
doaj   +1 more source

The Nucleic Acid Database: A Resource for Nucleic Acid Science [PDF]

Acta Crystallographica Section D Biological Crystallography, 1998
The Nucleic Acid Database (NDB) distributes information about nucleic acid-containing structures. Here the information content of the database as well as the query capabilities are described. A summary of how the technology developed by this project has been used to develop other macromolecular databases is given.
John D. Westbrook, Christine Zardecki, Helen M. Berman   +2 more
openaire   +3 more sources