Results 21 to 30 of about 6,062,195 (387)

The smfBox is an open-source platform for single-molecule FRET

Nature Communications, 2020
Broad uptake of smFRET has been hindered by high instrument costs and a lack of open-source hardware and acquisition software. Here, the authors present the smfBox, a cost-effective open-source platform capable of measuring precise FRET efficiencies ...
Benjamin Ambrose, James M. Baxter, John Cully, Matthew Willmott, Elliot M. Steele, Benji C. Bateman, Marisa L. Martin-Fernandez, Ashley Cadby, Jonathan Shewring, Marleen Aaldering, Timothy D. Craggs   +10 more
doaj   +1 more source

Ultrasensitive detection of nucleic acids using deformed graphene channel field effect biosensors

Nature Communications, 2020
Field-effect transistor (FET)-based biosensors allow label-free detection of biomolecules by measuring their intrinsic charges. The detection limit of these sensors is determined by the Debye screening of the charges from counter ions in solutions. Here,
M. T. Hwang, M. Heiranian, Yerim Kim, Seungyong You, Juyoung Leem, Amir Taqieddin, V. Faramarzi, Y. Jing, Insu Park, A. M. van der Zande, Sungwoo Nam, N. Aluru, R. Bashir   +12 more
semanticscholar   +1 more source

Deciphering the tRNA-derived small RNAs: origin, development, and future

Cell Death and Disease, 2021
Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a novel category of small noncoding RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the roles of tsRNAs in the development of human diseases.
Bowen Liu, Jinling Cao, Xiangyun Wang, Chunlei Guo, Yunxia Liu, Tianjiao Wang   +5 more
doaj   +1 more source

A bouquet of DNA structures: Emerging diversity

Biochemistry and Biophysics Reports, 2016
Structural polymorphism of DNA has constantly been evolving from the time of illustration of the double helical model of DNA by Watson and Crick. A variety of non-canonical DNA structures have constantly been documented across the globe.
Mahima Kaushik, Shikha Kaushik, Kapil Roy, Anju Singh, Swati Mahendru, Mohan Kumar, Swati Chaudhary, Saami Ahmed, Shrikant Kukreti   +8 more
doaj   +1 more source

An ultrasensitive photoelectrochemical nucleic acid biosensor [PDF]

, 2005
A simple and ultrasensitive procedure for non-labeling detection of nucleic acids is described in this study. It is based on the photoelectrochemical detection of target nucleic acids by forming a nucleic acid/photoreporter adduct layer on an ITO ...
Gao, Zhiqiang, Tansil, Natalia C.
core   +3 more sources

Polyvalent DNA nanoparticle conjugates stabilize nucleic acids.

Nano letters (Print), 2020
Polyvalent oligonucleotide gold nanoparticle conjugates have unique fundamental properties including distance-dependent plasmon coupling, enhanced binding affinity, and the ability to enter cells and resist enzymatic degradation.
D. Seferos, Andrew E. Prigodich, D. Giljohann, Pinal C. Patel, C. Mirkin   +4 more
semanticscholar   +1 more source

Modeling nucleic acids [PDF]

Current Opinion in Structural Biology, 2012
Nucleic acids are an important class of biological macromolecules that carry out a variety of cellular roles. For many functions, naturally occurring DNA and RNA molecules need to fold into precise three-dimensional structures. Due to their self-assembling characteristics, nucleic acids have also been widely studied in the field of nanotechnology, and ...
Sim, A, Minary, P, Levitt, M
openaire   +4 more sources

Self-association of Coralyne: An ordered thermal destacking

Results in Chemistry, 2020
Understanding DNA-ligand interactions is a prerequisite, for designing sequence/structure specific ligands. Generally, stabilization/destabilization of DNA structures as a function of ligand is studied using UV-thermal melting, and the data is usually ...
Shikha Kaushik, Mahima Kaushik, Ritu Barthwal, Shrikant Kukreti   +3 more
doaj   +1 more source

Nanostructured luminescently labeled nucleic acids [PDF]

, 2017
Important and emerging trends at the interface of luminescence, nucleic acids and nanotechnology are: (i) the conventional luminescence labeling of nucleic acid nanostructures (e.g. DNA tetrahedron); (ii) the labeling of bulk nucleic acids (e.g. single‐
Adleman, Ai, Beater, Bi, Branton, Cao, Casini, Chen, Corstjens, Deng, Ding, Ding, Ding, Divsar, Du, Duan, Dunn, ENCODE, Fortina, Fortina, Gerling, Gommers-Ampt, Goodman, Han, He, He, He, He, He, Hembury, Heuer-Jungemann, Horikoshi, Hu, Huang, Jia, Ke, Kim, Knoblauch, Kricka, Kricka, Kwok, Lee, Li, Li, Lin, Liu, Liu, Liu, Lu, Ma, Maden, Mouse ENCODE Consortium, Nangreave, Nirenberg, Obliosca, Orbach, Ozhalici-Unal, Park, Park, Parker, Petty, Pinehiro, Randeria, Ren, Richards, Rijke, Ritchie, Rotaru, Rothemund, Seeman, Seferos, Severcan, Sharma, Shchepinov, Shen, Simonetti, Stahl, Stolper, Taton, Vanyushin, Vasudevan, Vummidi, Wang, Wang, Wang, Wang, Wang, Wang, Wu, Wu, Yan, Yang, Yang, Yang, Ye, Yeh, Yu, Yuan, Yurke, Zhang, Zhang, Zhang, Zhang, Zhao, Zheng, Zhou   +105 more
core   +1 more source

Nucleic Acids Research

Nucleic Acids Research, 2015
Using mitotic cultures synchronised by a feed-starve protocol or by elutriation, we have shown that the yeast DNA polymerase I gene is periodically expressed with its transcript increasing at least 100-fold in late Gl with a peak around the Gl/S phase ...
Deborah J. Hurt, K. Winestock, M. O'connor, M. I. Johnston   +3 more
semanticscholar   +1 more source