Results 21 to 30 of about 1,008,745 (365)

EXPEDITED PCR WITH STIRRING [PDF]

open access: yes, 2021
Disclosed are an apparatus and methods for rapid amplification of nucleic acids. More particularly, the present dis closure relates to an apparatus for mixing a reaction solution during amplification of nucleic acids and to methods for amplifying nucleic
Viljoen, Hendrik
core   +4 more sources

Enhanced Hybridization Selectivity Using Structured GammaPNA Probes

open access: yesMolecules, 2020
High affinity nucleic acid analogues such as gammaPNA (γPNA) are capable of invading stable secondary and tertiary structures in DNA and RNA targets but are susceptible to off-target binding to mismatch-containing sequences.
Taylor D. Canady   +6 more
doaj   +1 more source

Lipid and Peptide-Oligonucleotide Conjugates for Therapeutic Purposes: From Simple Hybrids to Complex Multifunctional Assemblies

open access: yesPharmaceutics, 2023
Antisense and small interfering RNA (siRNA) oligonucleotides have been recognized as powerful therapeutic compounds for targeting mRNAs and inducing their degradation. However, a major obstacle is that unmodified oligonucleotides are not readily taken up
Carme Fàbrega   +5 more
doaj   +1 more source

Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences

open access: yesMolecules, 2021
RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are currently ...
Yaroslav Staroseletz   +7 more
doaj   +1 more source

Dendrimers in gene delivery [PDF]

open access: yes, 2005
Dendrimers have unique molecular architectures and properties that make them attractive materials for the development of nanomedicines. Key properties such as defined architecture and a high ratio of multivalent surface moieties to molecular volume also ...
Dufès, Christine   +2 more
core   +1 more source

Counting the ions surrounding nucleic acids. [PDF]

open access: yes, 2016
Nucleic acids are strongly negatively charged, and thus electrostatic interactions-screened by ions in solution-play an important role in governing their ability to fold and participate in biomolecular interactions.
Jacobson, David R, Saleh, Omar A
core   +1 more source

Characterization of benzopyrylium monomethine dyes as fluorescent probes for sensing and imaging of nucleic acids [PDF]

open access: yes, 2023
In this study, a series of benzopyrylium monomethine dyes bearing a benzothiazole moiety and mainly differing in their substitution pattern were characterized regarding their ability for nucleic acid binding and their use as fluorescent probes for ...
Biskup, Christoph   +2 more
core   +1 more source

Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model

open access: yesFrontiers in Pharmacology, 2019
Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases ...
Olga A. Patutina   +7 more
doaj   +1 more source

A Theoretical Mechanism of Szilard Engine Function in Nucleic Acids and the Implications for Quantum Coherence in Biological Systems [PDF]

open access: yesAIP Conf. Proc. 1316, July 2010, pp. 287-290, 2012
Nucleic acids theoretically possess a Szilard engine function that can convert the energy associated with the Shannon entropy of molecules for which they have coded recognition, into the useful work of geometric reconfiguration of the nucleic acid molecule.
arxiv   +1 more source

Ab Initio Nucleic Acid Folding Simulations Using a Physics-Based Atomistic Free Energy Model [PDF]

open access: yes, 2022
Performing full-resolution atomistic simulations of nucleic acid folding has remained a challenge for biomolecular modeling. Understanding how nucleic acids fold and how they transition between different folded structures as they unfold and refold has important implications for biology.
arxiv   +1 more source

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