Results 21 to 30 of about 449,751 (323)

Ultrashort Peptide Self-Assembly: Front-Runners to Transport Drug and Gene Cargos

open access: yesFrontiers in Bioengineering and Biotechnology, 2020
The translational therapies to promote interaction between cell and signal come with stringent eligibility criteria. The chemically defined, hierarchically organized, and simpler yet blessed with robust intermolecular association, the peptides, are ...
Seema Gupta   +4 more
doaj   +1 more source

Mechanistic Insight into Oxidative Stress-Triggered Signaling Pathways and Type 2 Diabetes

open access: yesMolecules, 2022
Oxidative stress (OS) is a metabolic dysfunction mediated by the imbalance between the biochemical processes leading to elevated production of reactive oxygen species (ROS) and the antioxidant defense system of the body.
Anju Singh   +3 more
doaj   +1 more source

Molecular Dynamics Analysis of Biomolecular Systems Including Nucleic Acids [PDF]

open access: yesarXiv, 2021
Along with recent progress in structural biology and genome biology, structural dynamics of molecular systems including nucleic acids has attracted attention in the context of gene regulation. Structure-function relationship is an important topic, where physicochemical properties of nucleotides are important as well as those of amino acids in proteins.
arxiv  

Nanosecond chain dynamics of single-stranded nucleic acids [PDF]

open access: yesarXiv, 2023
The conformational dynamics of single-stranded nucleic acids are fundamental for nucleic acid folding and function. However, their elementary chain dynamics have been difficult to resolve experimentally. Here we employ a combination of single-molecule F\"orster resonance energy transfer, nanosecond fluorescence correlation spectroscopy, fluorescence ...
arxiv  

Two-Holder Strategy for Efficient and Selective Synthesis of Lk 1 ssDNA Catenane

open access: yesMolecules, 2018
DNA catenanes are characterized by their flexible and dynamic motions and have been regarded as one of the key players in sophisticated DNA-based molecular machines.
Qi Li   +6 more
doaj   +1 more source

The Nucleic Acid Database: A Resource for Nucleic Acid Science [PDF]

open access: yesActa Crystallographica Section D Biological Crystallography, 1998
The Nucleic Acid Database (NDB) distributes information about nucleic acid-containing structures. Here the information content of the database as well as the query capabilities are described. A summary of how the technology developed by this project has been used to develop other macromolecular databases is given.
John D. Westbrook   +2 more
openaire   +3 more sources

Origin of Information Encoding in Nucleic Acids through a Dissipation-Replication Relation [PDF]

open access: yesEntropy 2020, 22(9), 940, 2018
Ultraviolet light incident on organic material can initiate its spontaneous dissipative structuring into chromophores which can then catalyze their own replication. This may have been the case for one of the most ancient of all chromophores dissipating the Archean UVC photon flux, the nucleic acids.
arxiv   +1 more source

Irisin Is Related to Non-Alcoholic Fatty Liver Disease (NAFLD)

open access: yesBiomedicines, 2022
Irisin is a cytokine involved in many metabolic pathways occurring, among others, in muscles, adipose tissue and liver. Thus, fluctuations in irisin levels are suggested to be related to metabolic diseases.
Marcin Kosmalski   +6 more
doaj   +1 more source

Absolute quantification of real-time PCR data with stage signal difference analysis [PDF]

open access: yesarXiv, 2021
Real-time PCR, or Real-time Quantitative PCR (qPCR) is an effective approach to quantify nucleic acid samples. Given the complicated reaction system along with thermal cycles, there has been long-term confusion on accurately calculating the initial nucleic acid amounts from the fluorescence signals.
arxiv  

Nucleic acid chemistry [PDF]

open access: yesBeilstein Journal of Organic Chemistry, 2014
Since the discovery of the structure of the DNA double helix in 1953 by Watson and Crick [1], we know that DNA is of critical importance, carrying the genetic information for all living organisms. Only a few years later appeared the first reports on the chemical synthesis of oligonucleotides with a natural 3'-5' phosphodiester linker by Michelsen and ...
openaire   +5 more sources

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