Results 51 to 60 of about 6,062,195 (387)
Beilstein Journal of Organic Chemistry, 2014 Since the discovery of the structure of the DNA double helix in 1953 by Watson and Crick [1], we know that DNA is of critical importance, carrying the genetic information for all living organisms. Only a few years later appeared the first reports on the chemical synthesis of oligonucleotides with a natural 3'-5' phosphodiester linker by Michelsen and ...
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Frontiers in Bioengineering and BiotechnologyIntroductionSmall membrane particles called extracellular vesicles (EVs) transport biologically active cargo between cells, providing intercellular communication.
Anastasiya Oshchepkova +15 more
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Two-Holder Strategy for Efficient and Selective Synthesis of Lk 1 ssDNA Catenane
Molecules, 2018 DNA catenanes are characterized by their flexible and dynamic motions and have been regarded as one of the key players in sophisticated DNA-based molecular machines.
Qi Li +6 more
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Mechanistic Insight into Oxidative Stress-Triggered Signaling Pathways and Type 2 Diabetes
Molecules, 2022 Oxidative stress (OS) is a metabolic dysfunction mediated by the imbalance between the biochemical processes leading to elevated production of reactive oxygen species (ROS) and the antioxidant defense system of the body.
Anju Singh +3 more
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Fluorescent labeling of plasmid DNA and mRNA : gains and losses of current labeling strategies [PDF]
, 2016 Live-cell imaging has provided the life sciences with insights into the cell biology and dynamics. Fluorescent labeling of target molecules proves to be indispensable in this regard. In this Review, we focus on the current fluorescent labeling strategies
Rombouts, Koen +2 more
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Use of streptavidin bound to biotinylated DNA structures as model substrates for analysis of nucleoprotein complex disruption by helicases [PDF]
, 2016 Helicases are a subfamily of translocases that couple the directional translocation along a nucleic acid lattice to the separation of nucleic acid duplexes using the energy derived from nucleoside triphosphate hydrolysis.
Brüning, Jan-Gert +2 more
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Molecular Therapy: Oncolytics, 2021 Resistance to the BCR-ABL inhibitor imatinib mesylate poses a major problem for the treatment of chronic myeloid leukemia. Imatinib resistance often results from a secondary mutation in BCR-ABL that interferes with drug binding.
Yanjun Liu +8 more
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FEBS Letters, EarlyView.Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke +2 more
wiley +1 more source
G-Quadruplex-Forming Aptamers—Characteristics, Applications, and Perspectives
Molecules, 2019 G-quadruplexes constitute a unique class of nucleic acid structures formed by G-rich oligonucleotides of DNA- or RNA-type. Depending on their chemical nature, loops length, and localization in the sequence or structure molecularity, G-quadruplexes are ...
Carolina Roxo +2 more
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Recent developments in nucleic acid identification using solid-phase enzymatic assays [PDF]
, 2014 This review (containing 101 references) covers recent achievements in the development of new approaches for enzymatically assisted detection of nucleic acids on microarrays. We discuss molecular techniques including the polymerase chain reaction, reverse
Ellis, Amanda Vera, Khodakov, Dmitriy A
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