Results 81 to 90 of about 1,078,683 (343)

MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response

Cell Reports, 2016
Through an RNAi-based screen for previously uncharacterized regulators of genome stability, we have identified the human protein C5orf45 as an important factor in preventing the accumulation of DNA damage in human cells.
Christopher J. Staples, Giancarlo Barone, Katie N. Myers, Anil Ganesh, Ian Gibbs-Seymour, Abhijit A. Patil, Ryan D. Beveridge, Caroline Daye, Richard Beniston, Sarah Maslen, Ivan Ahel, J. Mark Skehel, Spencer J. Collis   +12 more
doaj   +1 more source

UVB radiation induced effects on cells studied by FTIR spectroscopy

, 2010
We have made a preliminary analysis of the results about the eVects on tumoral cell line (lymphoid T cell line Jurkat) induced by UVB radiation (dose of 310 mJ/cm^2) with and without a vegetable mixture. In the present study, we have used two techniques:
A. Congiu Castellano, B Fadeel, C Di Pietro, D Pozzi, D. Pozzi, H Tuschl, I. Silvestri, JL Ravant, Lucia Di Giambattista, M Engeland Van, M Hagenhofer, M-E Legaz, M. Grandi, N Gault, N Jamin, P. Grimaldi, PG Andrus, S Gaudenzi, S. Gaudenzi, S. Morrone, SY Chor, Z Novak   +21 more
core   +1 more source

Bulges in nucleic acids

Current Opinion in Structural Biology, 1992
Abstract Bulges are important structural elements in RNA and DNA. Progress has been made in defining the sequence dependence of the structure and stability of bulges; however, the molecular interactions responsible for these sequence effects are not yet completely understood.
openaire   +2 more sources

Redesigning nucleic acids [PDF]

Pure and Applied Chemistry, 1998
Abstract
Simon E. Moroney, Christophe Hammer, Michael J. Lutz, Birgitte Hyrup, M. Blättler, Simona C. Jurczyk, Joseph Stackhouse, Andrew L. Roughton, Joseph A. Piccirilli, Christopher Switzer, Stefan Lutz, D. K. Bäschlin, U. von Krosigk, Steven A. Benner, Krishnan P. Nambiar, Heike A. Held, H. A. König, Clemens Richert, Thomas F. Jenny, Tuncer Arslan, J. T. Kodra, Jurgen G. Schmidt, Zh. Huang, Martin Egli, Klaus Schneider, E. Müller, L. J. MacPherson, Thomas R. Battersby, Bernd Eschgfäller, Daniel Hutter, J. J. Vögel, Jennifer Horlacher   +31 more
openaire   +3 more sources

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

Molecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond   +3 more
wiley   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Exploring RNA modifications in infectious non-coding circular RNAs

RNA Biology
Viroids, small circular non-coding RNAs, act as infectious pathogens in higher plants, demonstrating high stability despite consisting solely of naked RNA.
Pavel Vopalensky, Anton Škríba, Michela Chiumenti, Lucia Ďuričeková, Anna Šimonová, Ondřej Lukšan, Francesco Di Serio, Beatriz Navarro, Hana Cahova   +8 more
doaj   +1 more source

Hydrophobicity and Unique Folding of Selected Polymers

, 1998
In suitable environments, proteins, nucleic acids and certain synthetic polymers fold into unique conformations. This work shows that it is possible to construct lattice models of foldable heteropolymers by expressing the energy only in terms of ...
Vendruscolo, Michele
core   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Mechanisms of HIV-1 Nucleocapsid Protein Inhibition by Lysyl-Peptidyl-Anthraquinone Conjugates [PDF]

, 2016
The Nucleocapsid protein NCp7 (NC) is a nucleic acid chaperone responsible for essential steps of the HIV-1 life cycle and an attractive candidate for drug development.
Alice Sosic, Barbara Gatto, Cristina Parolin, Dan Fabris, Giuseppe Zagotto, Giuseppina Sabatino, Guo J., Ilaria Carli, Laura Sinigaglia, Marta Cappellini, Morellet N., Paolo Rovero, You J. C.   +12 more
core   +2 more sources