Results 31 to 40 of about 23,431 (250)

Calculations of pK_a Values for a Series of Naturally Occurring Modified Nucleobases

, 2022
Modified nucleobases are found in functionally important regions of RNA and are often responsible for essential structural roles. Many of these nucleobase modifications are dynamically regulated in nature, with each modification having a different ...
Sebastien P. Hebert (1351029), Alan J. Mlotkowski (12132898), H. Bernhard Schlegel (1288935), Christine S. Chow (2082214), Evan L. Jones (12132895)   +4 more
core   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Spontaneous Water-Promoted Self-Aggregation of a Hydrophilic Gold(I) Complex Due to Ligand Sphere Rearrangement

Molecules, 2023
Aggregating gold(I) complexes in solution through short aurophilic contacts promotes new photoluminescent deactivation pathways (aggregation-induced emission, AIE). The time dependence of spontaneous AIE is seldom studied.
Ainhoa Rodríguez-Gobernado, Daniel Blasco, Miguel Monge, José M. López-de-Luzuriaga   +3 more
doaj   +1 more source

Dereplication of Known Nucleobase and Nucleoside Compounds in Natural Product Extracts by Capillary Electrophoresis-High Resolution Mass Spectrometry

Molecules, 2015
Nucleobase and nucleoside compounds exist widely in various organisms. An often occurring problem in the discovery of new bioactive compounds from natural products is reisolation of known nucleobase and nucleoside compounds.
Junhui Chen, Qian Shi, Yanlong Wang, Zhaoyong Li, Shuai Wang   +4 more
doaj   +1 more source

Calculations of pK_a Values for a Series of Fluorescent Nucleobase Analogues

Compounds
Nucleobases play diverse structural and functional roles in biological systems. Understanding the fundamental properties of nucleobases is important for their applications as chemical probes of nucleic acid function.
Sun Jeong Im, Alan J. Mlotkowski, H. Bernhard Schlegel, Christine S. Chow   +3 more
doaj   +1 more source

Purine but Not Pyrimidine De Novo Nucleotide Biosynthesis Inhibitors Strongly Enhance the Antiviral Effect of Corresponding Nucleobases Against Dengue Virus

Molecules
Every year, dengue virus affects hundreds of millions of individuals worldwide. To date, there is no specific medication to treat dengue virus infections.
Laurent F. Bonnac, Christine D. Dreis, Madhu Rai, Robert J. Geraghty   +3 more
doaj   +1 more source

Nucleobase catalysis in the hairpin ribozyme [PDF]

RNA, 2006
RNA catalysis is important in the processing and translation of RNA molecules, yet the mechanisms of catalysis are still unclear in most cases. We have studied the role of nucleobase catalysis in the hairpin ribozyme, where the scissile phosphate is juxtaposed between guanine and adenine bases.
Timothy J, Wilson, Jonathan, Ouellet, Zheng-Yun, Zhao, Shinya, Harusawa, Lisa, Araki, Takushi, Kurihara, David M J, Lilley   +6 more
openaire   +2 more sources

Simple Organics and Biomonomers Identified in HCN Polymers: An Overview

Life, 2013
Hydrogen cyanide (HCN) is a ubiquitous molecule in the Universe. It is a compound that is easily produced in significant yields in prebiotic simulation experiments using a reducing atmosphere.
Susana Osuna-Esteban, María-Paz Zorzano, Marta Ruiz-Bermejo   +2 more
doaj   +1 more source

Graphene Oxide Nanoribbons in Chitosan for Simultaneous Electrochemical Detection of Guanine, Adenine, Thymine and Cytosine

Biosensors, 2020
Herein, graphene oxide nanoribbons (GONRs) were obtained from the oxidative unzipping of multi-walled carbon nanotubes. Covalent coupling reaction of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and N-hydroxy succinimide (NHS) with ...
Jiayun Zhou, Shaopei Li, Meissam Noroozifar, Kagan Kerman   +3 more
doaj   +1 more source

Plasmonic Chirality Imprinting on Nucleobase‐Displaying Supramolecular Nanohelices by Metal–Nucleobase Recognition [PDF]

Angewandte Chemie, 2017
AbstractSupramolecular self‐assembly is an important process that enables the conception of complex structures mimicking biological motifs. Herein, we constructed helical fibrils through chiral self‐assembly of nucleobase–peptide conjugates (NPCs), where achiral nucleobases are helically displayed on the surface of fibrils, comparable to polymerized ...
Yiyang Lin, E. Thomas Pashuck, Michael R. Thomas, Nadav Amdursky, Shih‐Ting Wang, Lesley W. Chow, Molly M. Stevens   +6 more
openaire   +5 more sources