Results 61 to 70 of about 84,247 (263)

Increased anti-nucleocapsid secretory IgA and consumption of complement component 3 in post-COVID syndrome patients. [PDF]

Front Immunol
Author contributions ZH: Conceptualization, Formal analysis, Funding acquisition, Investigation, Visualization, Writing – review & editing. WY: Conceptualization, Formal analysis, Funding acquisition, Investigation, Visualization, Writing – review ...
Hai Z, Yang W, Ghazi A, Buitrago A, Marín-García P, Azcárate IG, González-Escalada A, Rossi N, Benítez-Cruz J, Estévez-Benito I, Tortajada A, Regueiro JR, Bautista JM, Martinez-Quiles N.   +13 more
europepmc   +2 more sources

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Exosome-Based Multivalent Vaccine: Achieving Potent Immunization, Broadened Reactivity, and Strong T-Cell Responses with Nanograms of Proteins

Microbiology Spectrum, 2023
Currently approved vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have focused solely on the spike protein to provide immunity. The first vaccines were developed rapidly using spike mRNA delivered by lipid nanoparticles but
Mafalda Cacciottolo, Justin B Nice, Yujia Li, Michael J. LeClaire, Ryan Twaddle, Ciana L. Mora, Stephanie Y. Adachi, Esther R. Chin, Meredith Young, Jenna Angeles, Kristi Elliott, Minghao Sun   +11 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

First detection and characterisation of porcine hemagglutinating encephalomyelitis virus in the Czech Republic

Veterinární Medicína, 2019
Porcine hemagglutinating encephalomyelitis virus (PHEV) is a highly neurovirulent coronavirus that invades the central nervous system in piglets. The incidence of PHEV among pigs in many countries is rising, and the economic losses to the pig industry ...
Romana Moutelikova, Jana Prodelalova
doaj   +1 more source

Detection of SARS-CoV-2 Nucleocapsid, Spike, and Neutralizing Antibodies in Vaccinated Japanese

Viruses, 2022
Serological detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N), spike (S), and neutralizing antibodies (Abs) is commonly undertaken to evaluate the efficacy of vaccination.
Rie Midorikawa, Moriyuki Nakama, Hiroshi Furukawa, Shomi Oka, Takashi Higuchi, Hideaki Nagai, Nobuhiro Nagai, Shigeto Tohma   +7 more
doaj   +1 more source

A combined nucleocapsid vaccine induces vigorous SARS-CD8+ T-cell immune responses [PDF]

, 2005
Several studies have shown that cell-mediated immune responses play a crucial role in controlling viral replication. As such, a candidate SARS vaccine should elicit broad CD8+ T-cell immune responses.
Ghorbani, Masoud, Aucoin, Susan, Francisco Diaz-Mitoma, Naas, Turaya, Diaz-Mitoma, Francisco, Ali Azizi, Turaya Naas, Rita Frost, Catalina Soare, Helina Tadesse, Azizi, Ali, Masoud Ghorbani, Tadesse, Helina, Susan Aucoin, Soare, Catalina, Frost, Rita   +15 more
core   +1 more source

Comparison of Rapid and Automated Antigen Detection Tests for the Diagnosis of SARS-CoV-2 Infection

Diagnostics, 2022
SARS-CoV-2 viral antigen detection may be an interesting alternative to RT-PCR for the diagnosis of SARS-CoV-2 infection as a less laborious or expensive method but requires validation.
Dorian Petonnet, Stéphane Marot, Isabelle Leroy, Julien Cohier, Charline Ramahefasolo, Safietou Mansaly, Vincent Calvez, Anne-Geneviève Marcelin, Sonia Burrel   +8 more
doaj   +1 more source

Oligomerization of Uukuniemi virus nucleocapsid protein [PDF]

Virology Journal, 2010
Uukuniemi virus (UUKV) belongs to the Phlebovirus genus in the family Bunyaviridae. As a non-pathogenic virus for humans UUKV has served as a safe model bunyavirus in a number of studies addressing fundamental questions such as organization and regulation of viral genes, genome replication, structure and assembly.
Katz, Anna, Freiberg, Alexander N., Backstrom, Vera, Schulz, Axel R., Mateos, Angelo, Holm, Liisa, Pettersson, Ralf F., Vaheri, Antti, Flick, Ramon, Plyusnin, Alexander   +9 more
openaire   +4 more sources

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source