Results 81 to 90 of about 69,939 (210)

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Some Properties of Influenza Virus Nucleocapsids [PDF]

Journal of Virology, 1969
Nucleocapsids released from influenza virions by sodium deoxycholate sedimented heterogeneously in sucrose gradients. Highly infectious virus (complete) preparations yielded nucleocapsids with peak distributions at 64 and 56 S ; von Magnus type virus (incomplete) lacked 64 S nucleocapsids ...
D W, Kingsbury, R G, Webster
openaire   +2 more sources

Feline Infectious Peritonitis mRNA Vaccine Elicits Both Humoral and Cellular Immune Responses in Mice

Vaccines
Feline infectious peritonitis (FIP) is a devastating and often fatal disease caused by feline coronavirus (FCoV). Currently, there is no widely used vaccine for FIP, and many attempts using a variety of platforms have been largely unsuccessful due to the
Terza Brostoff, Hannah P. Savage, Kenneth A. Jackson, Joseph C. Dutra, Justin H. Fontaine, Dennis J. Hartigan-O’Connor, Randy P. Carney, Patricia A. Pesavento   +7 more
doaj   +1 more source

Signs of Cross‐Reactivity Between SARS‐CoV‐2 and Other Coronaviruses in a Pre‐Vaccine Swedish School Setting

Acta Paediatrica, EarlyView.
ABSTRACT Aim This pilot study explored signs of immunological cross‐reactivity between SARS‐CoV‐2 and human coronaviruses (HCoVs) in a Swedish school setting. Methods A cross‐sectional, hypothesis‐generating study was conducted late 2020 before vaccines against COVID‐19 were available.
Lina Schollin Ask, Sharon Kühlmann Berenzon, Ulrika Marking, Sara Nouiser, Andreas Bråve, Sören Andersson, Charlotta Nordenhäll, Tobias Alfvén, Teghesti Tecleab, Olof Hertting, Tyler Sandberg, Wanda Christ, Jonas Klingström, Kim Blom, Charlotta Nilsson   +14 more
wiley   +1 more source

Mechanism of SARS-CoV-2 Nucleocapsid Protein Phosphorylation-Induced Functional Switch

Viruses
The SARS-CoV-2 nucleocapsid protein (Np) is essential for viral RNA replication and genomic RNA packaging. Phosphorylation of Np within its central Ser-Arg-rich (SRR) linker is proposed to modulate these functions. To gain mechanistic insights into these
Megan S. Sullivan, Michael Morse, Kaylee Grabarkewitz, Dina Bayachou, Ioulia Rouzina, Vicki Wysocki, Mark C. Williams, Karin Musier-Forsyth   +7 more
doaj   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

HIV‐1 viral load and reservoir size remain stable following SARS‐CoV‐2 mRNA vaccination in people with HIV

HIV Medicine, EarlyView.
Abstract Background The potent immunogenicity of mRNA vaccination raised concerns about its impact on HIV‐1 viral load (VL) and reservoir size in people with HIV, which could drive vaccine hesitancy. As part of a prospective clinical trial, we investigated whether SARS‐CoV‐2 mRNA vaccination induced changes in VL and reservoir size after a 1‐year three‐
Oscar Kieri, Bianca B Jütte, Jan Vesterbacka, Soo Aleman, Hans‐Gustaf Ljunggren, Marcus Buggert, J Peter Svensson, Anders Sönnerborg, Piotr Nowak   +8 more
wiley   +1 more source

Interactions of Marburg Virus Nucleocapsid Proteins

Virology, 1998
In this study, the components of Marburg virus nucleocapsid complex were determined, and interactions between the compounds were investigated. Using salt dissociation of isolated virions, four proteins (NP, VP35, VP30, and L) remained attached to the core complex.
Becker, S., Rinne, C., Hofsäß, U., Klenk, H.-D., Mühlberger, E.   +4 more
openaire   +2 more sources

Characterisation of HIV‐1 Gag Cytotoxic T‐Lymphocyte Epitopes in the Southern African Region—A Systematic Review

Immunology, EarlyView.
Distribution of studies on HIV‐1 Gag cytotoxic T‐lymphocyte epitopes in the southern African region showing that the majority of studies (58.44%) were conducted in South Africa, followed by Botswana (15.58%), Zambia (10.39%), Malawi (7.79%), Zimbabwe (6.49%), and Angola (1.30%).
Tumelo L. Fortuin, Paballo Nkone, Shayne Loubser, Caroline T. Tiemessen, Simnikiwe H. Mayaphi   +4 more
wiley   +1 more source

Extracellular vesicles containing SARS‐CoV‐2 proteins are associated with multi‐organ dysfunction and worse outcomes in patients with severe COVID‐19

Journal of Extracellular Vesicles
The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes coronavirus disease 2019 (COVID‐19) and has been related to more than 7 million deaths globally since 2019.
Diego deMiguel‐Perez, Marisol Arroyo‐Hernandez, Sabrina La Salvia, Muthukumar Gunasekaran, Edward M. Pickering, Stephanie Avila, Etse Gebru, Eduardo Becerril‐Vargas, Sergio Monraz‐Perez, Kapil Saharia, Alison Grazioli, Michael T. McCurdy, Matthew Frieman, Lisa Miorin, Alessandro Russo, Andrés F. Cardona, Adolfo García‐Sastre, Sunjay Kaushal, Fred R. Hirsch, Djordje Atanackovic, Susmita Sahoo, Oscar Arrieta, Christian Rolfo   +22 more
doaj   +1 more source