Results 91 to 100 of about 69,939 (210)

Bovine Herpesvirus Type 4 (BoHV-4) Vector Delivering Nucleocapsid Protein of Crimean-Congo Hemorrhagic Fever Virus Induces Comparable Protective Immunity against Lethal Challenge in IFNα/β/γR−/− Mice Models

Viruses, 2019
Crimean-Congo hemorrhagic fever virus (CCHFV) is the causative agent of a tick-borne infection with a significant mortality rate of up to 40% in endemic areas, with evidence of geographical expansion.
Touraj Aligholipour Farzani, Katalin Földes, Alireza Hanifehnezhad, Burcu Yener Ilce, Seval Bilge Dagalp, Neda Amirzadeh Khiabani, Koray Ergünay, Feray Alkan, Taner Karaoglu, Hurrem Bodur, Aykut Ozkul   +10 more
doaj   +1 more source

Turnip mosaic virus utilizes the lipid droplet biogenesis machinery to facilitate its propagation in plants

New Phytologist, EarlyView.
Potyvirus turnip mosaic virus induces neutral lipid accumulation and lipid droplet biogenesis in infected leaves for its own benefit. Summary Lipid droplets (LDs), which are dedicated to storing neutral lipids (NLs), are dynamic organelles involved in numerous other functions, including membrane remodeling during abiotic stress.
Léna Jambou, Nathalie Arvy, Marguerite Batsale, Luc Sofer, Sara Shakir, Marielle Cochet, Vincent Simon, Charlotte Quinteau, Thomas Scotti, Nathan M. Doner, Satinder K. Gidda, Robert T. Mullen, Sabine D'Andréa, Jean‐Luc Gallois, Denis Coulon, Claire Bréhélin, Sylvie German‐Retana   +16 more
wiley   +1 more source

Writing Big in Plant Genomes: Advances, Challenges and Strategies for Targeted Large‐Fragment DNA Insertion

Plant, Cell &Environment, EarlyView.
ABSTRACT Precise genome editing has transformed plant biology and crop improvement by enabling targeted modification of endogenous loci. Beyond gene knockout and base editing, the site‐specific insertion of exogenous DNA, particularly large DNA fragments, has become a central goal for engineering complex traits, reconstructing metabolic pathways and ...
Fengfeng Zhang, Daqi Yan, Jiayi Hou, Dan Yang, Yan Xiong, Mingzhang Wen, Xiaoyue Zhu   +6 more
wiley   +1 more source

Co-Delivery Effect of CD24 on the Immunogenicity and Lethal Challenge Protection of a DNA Vector Expressing Nucleocapsid Protein of Crimean Congo Hemorrhagic Fever Virus

Viruses, 2019
Crimean Congo hemorrhagic fever virus (CCHFV) is the causative agent of a globally-spread tick-borne zoonotic infection, with an eminent risk of fatal human disease.
Touraj Aligholipour Farzani, Alireza Hanifehnezhad, Katalin Földes, Koray Ergünay, Erkan Yilmaz, Hiba Hashim Mohamed Ali, Aykut Ozkul   +6 more
doaj   +1 more source

Kidney Transplant Recipients Develop Nasal Mucosal Antibodies to SARS‐CoV‐2 With ACE2‐Inhibiting Activity Following mRNA Vaccination

Transplant Infectious Disease, EarlyView.
Kidney transplant recipients develop nasal mucosal antibodies after systemic COVID‐19 vaccination, which are able to inhibit binding of SARS‐CoV‐2 to the ACE2 receptor, but at a lower concentration than the general population. ABSTRACT Background Less than 60% of kidney transplant recipients (KTRs) become IgG seropositive for the viral spike (S ...
Vera J. C. H. Koomen, Christa E. van der Gaast‐deJongh, Fred van Opzeeland, Ria Philipsen, Marije C. Baas, A. Lianne Messchendorp, Frederike J. Bemelman, Marcia M. L. Kho, Carla C. Baan, Debbie van Baarle, Jan‐Stephan F. Sanders, Rob van Binnendijk, Gerco den Hartog, Ron T. Gansevoort, Renate G. van der Molen, Luuk B. Hilbrands, Dimitri A. Diavatopoulos   +16 more
wiley   +1 more source

The coronavirus nucleocapsid protein is ADP-ribosylated

Virology, 2018
ADP-ribosylation is a common post-translational modification, although how it modulates RNA virus infection is not well understood. While screening for ADP-ribosylated proteins during coronavirus (CoV) infection, we detected a ~55kDa ADP-ribosylated protein in mouse hepatitis virus (MHV)-infected cells and in virions, which we identified as the viral ...
Grunewald, Matthew E., Fehr, Anthony R., Athmer, Jeremiah, Perlman, Stanley   +3 more
openaire   +2 more sources

Life Course Malaria Exposure and SARS‐CoV‐2 Seroepidemiology in Ugandan Adolescents: A Longitudinal Study Nested in a Birth Cohort

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background COVID‐19 has had major global health impacts, yet reported morbidity and mortality have been lower in Africa despite serological evidence of widespread infection. Malaria has been proposed as a potential modifier of susceptibility to and outcomes of SARS‐CoV‐2 infection.
Ludoviko Zirimenya, Doreen Nayebare, Claire Baine, Jacent Nassuuna, Milly Namutebi, Christopher Zziwa, Denis Nsubuga, Fred Kiwudhu, Florence Akello, Josephine Tumusiime, Gloria Oduru, Grace Kabami, Hellen Akurut, Rachel Nakyesige, Agnes Natukunda, Anne Wajja, Lawrence Lubyayi, Simon Kimuda, Gyaviira Nkurunungi, Jennifer Serwanga, Katie J. Doores, Emily L. Webb, Alison M. Elliott   +22 more
wiley   +1 more source

Observations on the Structure of the Nucleocapsids of some Paramyxoviruses

Journal of General Virology, 1970
Summary The intact particles and nucleocapsids of mumps, Sendai and measles viruses are of closely similar appearance, size and structure. The intact particles are about 150 nm. in diameter. The filamentous nucleocapsids have a modal length of about 1.1 µm., and are constructed of subunits arranged as a single start helix of pitch 5.0 nm.
J T, Finch, A J, Gibbs
openaire   +2 more sources

Impact of delayed blood donation sample processing and testing on SARS‐CoV‐2 serological assay results in an evolving pandemic response

Transfusion, EarlyView.
Abstract Background The two largest US blood collection organizations led a multiphased, multicenter nationwide SARS‐CoV‐2 blood donor‐based serosurveillance program. The potential impact of delayed sample processing and prolonged refrigerated or frozen storage on anti‐SARS‐CoV‐2 antibody detection was investigated.
Marion C. Lanteri, Valerie Green, Hasan Sulaeman, Mars Stone, James Haynes, Clara Di Germanio, Sakina Smith, Patricia G. Villaflor, Jamel Groves, Phillip C. Williamson, Susan L. Stramer, Melissa M. Coughlin, Jefferson M. Jones, Eduard Grebe, Michael P. Busch, Paula Saa   +15 more
wiley   +1 more source

Spike specific IgG3 and nucleocapsid IgG response in serum serve as distinguishing immunological markers between SARS-CoV-2 infection and vaccination

Frontiers in Immunology
BackgroundBoth SARS-CoV-2 infection and COVID-19 vaccines elicit immunological responses. However, it is difficult to distinguish responses generated after vaccination versus natural infection.MethodsWe investigated SARS-CoV-2 spike receptor-binding ...
Marjahan Akhtar, Md. Rashedul Islam, Fatema Khaton, Fatima Rahman, Tausif Adnan Sami, Imam Tauheed, Tasnuva Ahmed, Afroza Akter, Ishtiakul Islam Khan, Zahid Hasan Khan, Prasanta Kumar Biswas, Edward T. Ryan, Edward T. Ryan, Edward T. Ryan, Sayera Banu, Tahmina Shirin, Fahima Chowdhury, Ashraful Islam Khan, Taufiqur Rahman Bhuiyan, Firdausi Qadri   +19 more
doaj   +1 more source