Results 71 to 80 of about 79,219 (253)

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Oligomerization of Uukuniemi virus nucleocapsid protein [PDF]

Virology Journal, 2010
Uukuniemi virus (UUKV) belongs to the Phlebovirus genus in the family Bunyaviridae. As a non-pathogenic virus for humans UUKV has served as a safe model bunyavirus in a number of studies addressing fundamental questions such as organization and regulation of viral genes, genome replication, structure and assembly.
Katz Anna, Freiberg Alexander N, Backström Vera, Schulz Axel R, Mateos Angelo, Holm Liisa, Pettersson Ralf F, Vaheri Antti, Flick Ramon, Plyusnin Alexander   +9 more
openaire   +3 more sources

ANDV nucleocapsid protein inhibits granzyme B-activity. [PDF]

, 2013
Analysis of possible interactions between ANDV nucleocapsid protein and granzyme B. (A) Western blot analyses showing cleaved fragments of the ANDV nucleocapsid protein (ANDV-N) after incubation with recombinant granzyme B. Full-length and cleaved ANDV-N
Karin B. Sundström (337165), Nicole D. Tischler (395814), Shawon Gupta (395812), Monika Braun (395813), Jonas Klingström (45509), Malin Stoltz (337164), Niklas K. Björkström (339612), Hans-Gustaf Ljunggren (189410)   +7 more
core   +1 more source

Multiplexed Flow Cytometric Approach for Detection of Anti-SARS-CoV-2 IgG, IgM and IgA Using Beads Covalently Coupled to the Nucleocapsid Protein [PDF]

, 2021
Flow cytometry has emerged as a promising technique for detection of SARS-CoV-2 antibodies. In this study, we described a new methodology to detect simultaneously IgG, IgM and IgA of SARS-CoV-2 nucleocapsid protein in human serum by flow cytometry.
Ingrid Fatima, Zattoni, Edileusa C. M., Gerhardt, Jeanine M., Nardin, Geraldo, Picheth, Alexia Marques Fernandes dos, Santos, Glaucio, Valdameri, Luciano F., Huergo, Fabiane Gomes de Moraes, Rego, Vivian Rotuno, Moure   +8 more
core   +1 more source

The Performances of Three Commercially Available Assays for the Detection of SARS-CoV-2 Antibodies at Different Time Points Following SARS-CoV-2 Infection

Viruses, 2022
The aim of this study was to evaluate the performances of three commercially available antibody assays for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies at different time points following SARS-CoV-2 infection ...
Heidi Syre, Marius Eduardo Brå Obreque, Ingvild Dalen, Åse Garløv Riis, Åse Berg, Iren Høyland Löhr, Jon Sundal, Lars Kåre Kleppe, May Sissel Vadla, Ole Bernt Lenning, Jan Stefan Olofsson, Kristin Greve-Isdahl Mohn, Camilla Tøndel, Bjørn Blomberg, Mai Chi Trieu, Nina Langeland, Rebecca Jane Cox   +16 more
doaj   +1 more source

Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication

Advanced Science, EarlyView.
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan, Chenyang Yuan, Zekun Meng, Yanan Wang, Xueying Zhai, Chunjie Huang, Xiang Zhou, Gaiping Zhang   +7 more
wiley   +1 more source

Detrimental Effects of Anti-Nucleocapsid Antibodies in SARS-CoV-2 Infection, Reinfection, and the Post-Acute Sequelae of COVID-19

Pathogens
Antibody-dependent enhancement (ADE) is a phenomenon in which antibodies enhance subsequent viral infections rather than preventing them. Sub-optimal levels of neutralizing antibodies in individuals infected with dengue virus are known to be associated ...
Emi E. Nakayama, Tatsuo Shioda
doaj   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Designing an ELISA Method for Measurement of Human IgG and IgM Antibodies against SARS-CoV-2

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: Coronavirus disease 2019 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Saeid Taghiloo, Mina Dabiri, Reza Valadan, Hossein Asgarian Omran   +3 more
doaj  

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source