Results 111 to 120 of about 3,660,966 (235)

OXCT1‐driven succinylation of PSMG3 stabilizes the proteasome to facilitate picornavirus replication

iMetaOmics, EarlyView.
Upon entering the pig, foot‐and‐mouth disease virus (FMDV) regulates host glycolysis and the citrate cycle by modulating the expression of metabolic enzymes, resulting in changes in post‐translational modifications (PTMs) including succinylation, lactylation, crotonylation, acetylation, and phosphorylation.
Huisheng Liu, Qiao Xue, Pengfei Liu, Zhihua Dong, Weijun Cao, Fan Yang, Yingming Zhu, Lei Deng, Zixiang Zhu, Haixue Zheng   +9 more
wiley   +1 more source

ANDV nucleocapsid protein inhibits granzyme B-activity.

, 2013
Analysis of possible interactions between ANDV nucleocapsid protein and granzyme B. (A) Western blot analyses showing cleaved fragments of the ANDV nucleocapsid protein (ANDV-N) after incubation with recombinant granzyme B. Full-length and cleaved ANDV-N
Karin B. Sundström (337165), Nicole D. Tischler (395814), Shawon Gupta (395812), Monika Braun (395813), Jonas Klingström (45509), Malin Stoltz (337164), Niklas K. Björkström (339612), Hans-Gustaf Ljunggren (189410)   +7 more
core   +1 more source

The Epitope Study on the SARS-CoV Nucleocapsid Protein

Genomics, Proteomics & Bioinformatics, 2003
Abstract The nucleocapsid protein (N protein) has been found to be an antigenic protein in a number of coronaviruses. Whether the N protein in severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is antigenic remains to be elucidated.
Li, Shuting, Lin, Liang, Wang, Hao, Yin, Jianning, Ren, Yan, Zhao, Zhe, Wen, Jie, Zhou, Cuiqi, Zhang, Xumin, Li, Xiaolei, Wang, Jingqiang, Zhou, Zhengfeng, Liu, Jinxiu, Shao, Jianmin, Lei, Tingting, Fang, Jianqiu, Xu, Ningzhi, Liu, Siqi   +17 more
openaire   +2 more sources

Molecular characterization of SARS-CoV-2 nucleocapsid protein

Frontiers in Cellular and Infection Microbiology
Corona Virus Disease 2019 (COVID-19) is a highly prevalent and potent infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Until now, the world is still endeavoring to develop new ways to diagnose and treat COVID-19.
Yanping Huang, Yanping Huang, Junkai Chen, Junkai Chen, Siwei Chen, Siwei Chen, Congcong Huang, Congcong Huang, Bei Li, Bei Li, Bei Li, Jian Li, Jian Li, Jian Li, Zhixiong Jin, Zhixiong Jin, Zhixiong Jin, Qiwei Zhang, Pan Pan, Weixing Du, Long Liu, Long Liu, Long Liu, Zhixin Liu, Zhixin Liu, Zhixin Liu   +25 more
doaj   +1 more source

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

Assembly of SARS-CoV-2 nucleocapsid protein with nucleic acid [PDF]

The viral genome of SARS-CoV-2 is packaged by the nucleocapsid (N-)protein into ribonucleoprotein particles (RNPs), 38 ± 10 of which are contained in each virion. Their architecture has remained unclear due to the pleomorphism of RNPs, the high
Syed, Abdullah M, Ott, Melanie, Nguyen, Ai, Srinivasan, Sanjana, Piszczek, Grzegorz, Ciling, Alison, Wu, Di, Schuck, Peter, Zhao, Huaying, Khalid, Mir M, Yau, Wai-Ming, Esposito, Dominic, Doudna, Jennifer A   +12 more
core   +1 more source

Preparation of recombinant SARS-CoV-2 nucleocapsid protein

Ветеринария сегодня
Introduction. The new coronavirus infection (COVID-19) agent SARS-CoV-2 has become widespread in the world and has caused the pandemic that started in 2019.
A. S. Yakovleva, A. V. Kanshina, A. M. Timina   +2 more
doaj   +1 more source

Recent Advances (2023–2025) of Capillary Electrophoresis‐Mass Spectrometry (CE‐MS) for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu, David A. Alvarez Rodriguez, Noah Gould, Alexander R. Ivanov, Kevin Jooß, Liangliang Sun   +5 more
wiley   +1 more source

Retrospective on the all-in-one retroviral nucleocapsid protein

Virus Research, 2014
This review aims at briefly presenting a retrospect on the retroviral nucleocapsid protein (NC), from an unspecific nucleic acid binding protein (NABP) to an all-in-one viral protein with multiple key functions in the early and late phases of the retrovirus replication cycle, notably reverse transcription of the genomic RNA and viral DNA integration ...
Darlix, Jean-Luc, de Rocquigny, Hugues, Mauffret, Olivier, Mély, Yves   +3 more
openaire   +3 more sources

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source