Results 131 to 140 of about 3,660,966 (235)

Paradoxical G-quadruplex distribution in coronavirus genomes reveals functional constraints and antiviral therapeutic opportunities

Virus Research
We computationally characterized G-quadruplex (G4) distributions across 31 coronavirus genomes to identify conserved structural features as potential antiviral therapeutic targets.
Masato Tanigawa, Takafumi Iwaki
doaj   +1 more source

Time‐Resolved Multi‐Omics Identify Biomarkers of Immediate Reactions to mRNA Vaccination

Allergy, EarlyView.
We compared early vaccine‐induced immune and metabolic signatures and downstream immunity after second and booster BNT162b2 doses in participants with sARs, ISSRs, or no reactions. Neutrophil mobilization, antiviral programs, and robust anti‐S‐antibody responses occurred across reaction groups.
Ana Olivera, Benjamin Schwarz, Brittany Dulek, Ian S. LaCroix, Min Li, Lindsay Chatman, Muhammad B. Khalid, Ellen Zektser, Karen Laky, Stella Hartono, Eric Bohrnsen, Cole D. Kimzey, Eric Chu, Roa Harb, Pamela A. Frischmeyer‐Guerrerio   +14 more
wiley   +1 more source

Nucleocapsid independent assembly of coronavirus like particles by co expression of viral envelope protein genes

, 1996
Budding of enveloped viruses has been shown to be driven by interactions between a nucleocapsid and a proteolipid membrane. By contrast, we here describe the assembly of viral envelopes independent of a nucleocapsid.
Rottier, P J, Rossen, J W, Horzinek, M.C., Rottier, P.J.M., Vennema, H, Horzinek, M C, Vennema, H., Rossen, J.W.A., Voorhout, W F, Godeke, G.-J., Voorhout, W.F., Opstelten, D.J., Rossen, J W; id_orcid, Godeke, G J, Opstelten, D J   +14 more
core   +1 more source

Olfactory Tuft Cells Are Critical to Basal Inflammation, Innate Immune Response to Viral Infection, and Modulation of Quiescent Stem Cell Activation, Proliferation and Differentiation

Cell Proliferation, EarlyView.
Olfactory tuft cells communicate with other mucosal cells in maintaining olfactory epithelial immunity and sensory function. Disruption of tuft cell signalling pathways causes a skewed immune response, leading to heightened inflammation and increased activation of the quiescent stem cells, which are further exacerbated by viral infection.
Sai‐Sai Zhang, Haiyan Wang, Yi‐Sen Yang, Yi‐Hong Li, Defu Yu, Yushi Yao, Ruhong Zhou, Liquan Huang   +7 more
wiley   +1 more source

A comparative analysis of cell death signalling in RNA and DNA virus infections and potential inhibitory strategies

The FEBS Journal, EarlyView.
RNA and DNA viruses can manipulate host cell death through various mechanisms. RNA viruses (H1N1, SARS‐CoV‐2) induce acute apoptosis, necroptosis, and pyroptosis to promote rapid viral transmission and epithelial barrier damage. In contrast, DNA viruses (HSV‐1, EBV) regulate these mechanisms to sustain a lytic‐latency cycle, evade immune response and ...
Panagiotis Keramidas, Maria Pitou, Amalia Aggeli, Sotiris Varlamis, Theodora Choli‐Papadopoulou   +4 more
wiley   +1 more source

Probing the HIV-1 NCp7 Nucleocapsid Protein with Site-Specific Gold(I)–Phosphine Complexes

, 2017
CAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOIn this work, we examined a series of thiophilic Au(I) compounds based on [Au(L)(PR3)] (L = Cl–, 4 ...
Paiva, Raphael E. F. de, Peterson, Erica J., Du, Zhifeng, Farrell, Nicholas P., Corbi, Pedro P., Pedro P. Corbi, Peterson, Erica J, Farrell, Nicholas P, Zhifeng Du, Nicholas P. Farrell, de Paiva, Raphael EF, Corbi, Pedro P, Raphael E. F. de Paiva, Erica J. Peterson   +13 more
core   +1 more source

Characterization of protein-protein interactions between the nucleocapsid protein and membrane protein of the avian infectious bronchitis virus [PDF]

, 2016
Avian infectious bronchitis virus (IBV) is one of the major viral respiratory diseases of chickens. Better understanding of the molecular mechanism of viral pathogenesis may contribute significantly to the development of prophylactic, therapeutic and ...
Cao, Haipeng, Zhao, Sujun, Zhang, Pengju, Liu, Yinglin, Zeng, Zhiguang, Wang, Hongning, Feng, Lang   +6 more
core   +1 more source

Interaction between molecules of hantavirus nucleocapsid protein

Journal of General Virology, 2001
Intermolecular interactions of Tula hantavirus N (nucleocapsid) protein were detected in the yeast two-hybrid system, prompting further attempts to study this phenomenon. Using chemical cross-linking and immunoblotting it was shown that the N protein from purified virus and from infected cell lysates as well as recombinant protein produced in a ...
Pasi, Kaukinen, Vesa, Koistinen, Olli, Vapalahti, Antti, Vaheri, Alexander, Plyusnin   +4 more
openaire   +2 more sources

Genome‐scale evidence for host‐associated lineage divergence in the parasitoid, Microctonus aethiopoides

Insect Molecular Biology, EarlyView.
Host associations are primary drivers of genomic divergence, with clear phylogenetic separation observed between strains associated with Hypera and Sitona weevil hosts. Genomic diversity aligns with reproductive modes: sexually reproducing ancestral lineages maintain high heterozygosity, while derived asexual strains exhibit reduced heterozygosity and ...
Meeran Hussain, Elahe Parvizi, Mark R. McNeill, Angela McGaughran   +3 more
wiley   +1 more source

Reactogenicity and Immunogenicity of RSV Vaccines in Immunocompromised Individuals With Hematological Malignancies

Transplant Infectious Disease, EarlyView.
In adults with hematologic malignancies, RSV vaccination was safe and induced antibody and T‐cell responses. However, antibody levels were lower and declined more rapidly than in healthy controls. While early immune responses were evident, reduced magnitude and durability of protection suggest the need for optimized vaccination strategies in this high ...
Alisse Hannaford, Zoe Swank, Simon D. van Haren, Natalie Izaguirre, Caitlin Syphurs, Zhou Lan, Bridget Yates, Urwah Kanwal, Grace Valentine, Ella Woehl, David Regan, Hannah Levine, Alexandra Tong, Maria Shehata, Fathia Oladipupo, Colleen Sedney, Kevin Ryff, Sanya Thomas, Joann Diray‐Arce, Xiaofang Li, Kimberly A. Dufresne, Lindsey A. Parisi, Aidan Eustace, Louise Hansen, David R. Walt, Ofer Levy, Amar Kelkar, Robert J. Soiffer, Vincent T. Ho, Lindsey R. Baden, Nicolas C. Issa, Ann E. Woolley, Amy C. Sherman   +32 more
wiley   +1 more source