Results 141 to 150 of about 3,660,966 (235)

SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia

The Journal of Physiology, EarlyView.
Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu, Asish Dasgupta, Jaskaran Singh Hora, Kuang‐Hueih Chen, Arinjay Banerjee, Stephen L. Archer   +5 more
wiley   +1 more source

Rice Orange Leaf Phytoplasma Imp Protein Blocks G–M Interaction by Binding Glycoprotein G to Suppress Rice Stripe Mosaic Virus Infection

Plant, Cell &Environment, Volume 49, Issue 12, Page 9649-9663, December 2026.
ABSTRACT Plants frequently encounter multiple pathogens concurrently, yet the molecular bases of pathogen–pathogen interactions during mixed infections remain largely unresolved. Here we show that co‐infection of rice by Rice orange leaf phytoplasma (ROLP) and Rice stripe mosaic virus (RSMV) markedly suppresses RSMV proliferation in both host plants ...
Jiaxin Qiu, Yujiao Zheng, Yanmei Yi, Yuxin Zhang, Tianbao Zeng, Hongyan Chen, Taiyun Wei, Xiao‐Feng Zhang   +7 more
wiley   +1 more source

Engineering Mosaic T7 Bacteriophages for Dual Peptide Display to Enable Cellular Targeting and Ligand‐Directed Protein Capture

Biotechnology Journal, Volume 21, Issue 11, November 2026.
Graphical Abstract and Lay Summary A mosaic T7 phage platform enables simultaneous display of two independent peptides on the same phage particle. The modular design integrates receptor targeting, protein capture, and tissue‐directed in vivo phage display, establishing a versatile methodology for multifunctional phage engineering, receptor ...
Luca Marchetti, Kristina Põšnograjeva, Prakash Lingasamy, Karlis Pleiko, Ivar Ilves, Tambet Teesalu   +5 more
wiley   +1 more source

Characterization of SARS-CoV-2 nucleocapsid protein oligomers [PDF]

Oligomers of the SARS-CoV-2 nucleocapsid (N) protein are characterized by pronounced instability resulting in fast degradation. This property likely relates to two contrasting behaviors of the N protein: genome stabilization through a compact ...
Farci, Domenica,, Kereïche, Sami,, Hall, Michael, Schröder, Wolfgang P, Haniewicz, Patrycja,, Faull, Peter,, Schröder, Wolfgang P.,, Graça, André T.,, Piano, Dario,, Haniewicz, Patrycja, Kirkpatrick, Joanna,, Hall, Michael,, Faull, Peter, Graça, André T, Piano, Dario, Tramontano, Enzo,, Farci, Domenica, Kereïche, Sami, Kirkpatrick, Joanna, Tramontano, Enzo   +19 more
core   +1 more source

Deciphering Host Genomic Pathway Landscapes in Severe COVID‐19 by Exome Sequencing of a Large Admixed Brazilian Cohort

Journal of Medical Virology, Volume 98, Issue 11, November 2026.
ABSTRACT The host genetic factors that resulted in the heterogeneous clinical outcomes of COVID‐19 remained poorly understood, especially in admixed populations that are underrepresented in global genomic studies. In this study, we investigated the genetic landscape associated with COVID‐19 severity using whole‐exome sequencing data from 325 Brazilian ...
Aléxia Stefani Siqueira Zetum, Danielle Ribeiro Campos da Silva, Vinícius do Prado Ventorim, Felipe Ataides Mion, Felipe dos Santos Passarela, Patrícia Brasil, Túlio de Lima Campos, Bartolomeu Acioli‐Santos, Flávio Rosendo da Silva Oliveira, Raquel Silva dos Reis Trabach, Lorena Souza Castro Altoé, Débora Dummer Meira, Iúri Drumond Louro   +12 more
wiley   +1 more source

Nucleocapsid Protein of SARS-CoV-2 Upregulates RANTES Expression in A172 Glioblastoma Cells

Molecules
SARS-CoV-2, the pathogenic virus that induces COVID-19 disease, contains four structural proteins in its virion. The nucleocapsid (N) protein is one of the four structural proteins that play a crucial role in the assembly of viral RNA into ...
Bakhytgul Gadilgereyeva, Zhanar Kunushpayeva, Mira Abdrakhmanova, Aizere Khassenova, Nail Minigulov, Timo Burster, Olena Filchakova   +6 more
doaj   +1 more source

Naturally Occurring ZCCHC3 Variants Modulate Antiretroviral Activity in Cynomolgus Macaques

Microbiology and Immunology, Volume 70, Issue 11, Page 543-553, November 2026.
ABSTRACT Many mammalian cells restrict viral replication by utilizing various host restriction factors. We recently demonstrated that CCHC‐type zinc‐finger‐containing protein 3 (ZCCHC3) suppresses human immunodeficiency virus type 1 (HIV‐1) replication through multiple mechanisms.
Jacob Fadipe, Tomotaka Okamura, Shige H. Yoshimura, Akatsuki Saito   +3 more
wiley   +1 more source

Complex interactions of HIV-1 nucleocapsid protein with oligonucleotides-0

, 2011
Copyright information:Taken from "Complex interactions of HIV-1 nucleocapsid protein with oligonucleotides"Nucleic Acids Research 2006;34(3):1082-1082.Published online 13 Feb 2006PMCID:PMC1369284.© The Author 2006.
Nathan A. Hagan (14374), Robert J. Gorelick (14384), Louis E. Henderson (14386), Matthew J. Fivash (14372), Karen L. McNitt (14381), Karen M. Worthy (14378), Donald G. Johnson (14382), Robert J. Fisher (14371), John T. Simpson (14379), Shilpa R. Shenoy (14375), Alan Rein (14387), Catherine V. Hixson (14383), Daniele Fabris (14385), Maxine V. Medaglia (14376), Lindsey R. Smith (14377), Andrew G. Stephen (14373), Robert Shoemaker (14380)   +16 more
core   +1 more source

Signs of Cross‐Reactivity Between SARS‐CoV‐2 and Other Coronaviruses in a Pre‐Vaccine Swedish School Setting

Acta Paediatrica, Volume 115, Issue 11, Page 2616-2624, November 2026.
ABSTRACT Aim This pilot study explored signs of immunological cross‐reactivity between SARS‐CoV‐2 and human coronaviruses (HCoVs) in a Swedish school setting. Methods A cross‐sectional, hypothesis‐generating study was conducted late 2020 before vaccines against COVID‐19 were available.
Lina Schollin Ask, Sharon Kühlmann Berenzon, Ulrika Marking, Sara Nouiser, Andreas Bråve, Sören Andersson, Charlotta Nordenhäll, Tobias Alfvén, Teghesti Tecleab, Olof Hertting, Tyler Sandberg, Wanda Christ, Jonas Klingström, Kim Blom, Charlotta Nilsson   +14 more
wiley   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, Volume 36, Issue 6, November 2026.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source