Results 71 to 80 of about 3,660,966 (235)

An insight into SARS-CoV-2 membrane protein interaction with spike, envelope, and nucleocapsid proteins

, 2021
Intraviral protein–protein interactions are crucial for replication, pathogenicity, and viral assembly. Among these, virus assembly is a critical step as it regulates the arrangements of viral structural proteins and helps in the encapsulation of genomic
Prateek Kumar (802333), Amit Kumar (81180), Neha Garg (194824), Rajanish Giri (6115907)   +3 more
core   +1 more source

The SARS coronavirus nucleocapsid protein – Forms and functions

Antiviral Research, 2014
The nucleocapsid phosphoprotein of the severe acute respiratory syndrome coronavirus (SARS-CoV N protein) packages the viral genome into a helical ribonucleocapsid (RNP) and plays a fundamental role during viral self-assembly. It is a protein with multifarious activities.
Chang, Chung-ke, Hou, Ming-Hon, Chang, Chi-Fon, Hsiao, Chwan-Deng, Huang, Tai-huang   +4 more
openaire   +2 more sources

The interaction between the Nipah virus nucleocapsid protein and phosphoprotein regulates virus replication

Scientific Reports, 2018
Continued outbreaks of Henipaviruses in South Asia and Australia cause severe and lethal disease in both humans and animals. Together, with evidence of human to human transmission for Nipah virus and the lack of preventative or therapeutic measures, its ...
Charlene Ranadheera, Roxanne Proulx, Mark Chaiyakul, Shane Jones, Allen Grolla, Anders Leung, John Rutherford, Darwyn Kobasa, Michael Carpenter, Markus Czub   +9 more
doaj   +1 more source

An Electrochemical Immunosensor Based on Carboxylated Graphene/SPCE for IgG-SARS-CoV-2 Nucleocapsid Determination

Biosensors, 2022
The COVID-19 pandemic has emphasized the importance and urgent need for rapid and accurate diagnostic tests for detecting and screening this infection.
Luciana de Souza Freire, Camila Macena Ruzo, Bárbara Batista Salgado, Ariamna María Dip Gandarilla, Yonny Romaguera-Barcelay, Ana P. M. Tavares, Maria Goreti Ferreira Sales, Isabelle Cordeiro, Jaila Dias Borges Lalwani, Robert Matos, Henrique Fonseca Filho, Spartaco Astolfi-Filho, Ştefan Ţălu, Pritesh Lalwani, Walter Ricardo Brito   +14 more
doaj   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Dose absorption of Omicron variant SARS-CoV-2 by electron radiation: Using Geant4-DNA toolkit

Nuclear Engineering and Technology
In this research, the Omicron variant of the SARS-CoV-2 virus was simulated and exposed to electron radiation with up to 20 keV energy. Absorbed energy was measured for spike protein, nucleocapsid protein, and envelope of the virus.
Mehrdad Jalili Torkamani, Chiman Karami, Pooneh Sayyah-Koohi, Farhood Ziaie, Seyyedsina Moosavi, Farhad Zolfagharpour   +5 more
doaj   +1 more source

An ATP‐Driven N Protein–DDX21 Molecular Switch Dynamically Controls SARS‐CoV‐2 RNA G‐Quadruplex Heterogeneity

Advanced Science, EarlyView.
An ATP‐driven molecular switch, comprising viral nucleocapsid (N) protein and host helicase DDX21, dynamically modulates SARS‐CoV‐2 RNA G‐quadruplex (G4) heterogeneity. These viral G4s feature non‐canonical ion‐dependence and act as energy‐sensitive structural checkpoints.
Ya‐Ting Zheng, Li‐Yan Zhai, Jie Jin, Qiu‐Ying Chen, Hang Fu, Xue‐Qian Sun, Ying Lu, Hui Li, Xi‐Miao Hou   +8 more
wiley   +1 more source

Comparative Assessment of Sera from Individuals after S-Gene RNA-Based SARS-CoV-2 Vaccination with Spike-Protein-Based and Nucleocapsid-Based Serological Assays

Diagnostics, 2021
Due to the beginning of vaccination against COVID-19, serological discrimination between vaccine-associated humoral response and serology-based surveillance of natural SARS-CoV-2 infections as well as breakthrough infections becomes an issue of relevance.
Anja Dörschug, Hagen Frickmann, Julian Schwanbeck, Elif Yilmaz, Kemal Mese, Andreas Hahn, Uwe Groß, Andreas E. Zautner   +7 more
doaj   +1 more source

Viable porcine arteriviruses with deletions proximal to the 3 ' end of the genome [PDF]

, 2001
In order to obtain attenuated live vaccine candidates of porcine reproductive and respiratory syndrome virus (PRRSV), a series of deletions was introduced at the 3′ end of the viral genome using an infectious cDNA clone of the Lelystad virus isolate. RNA
Rottier, P.J.M., Meulenberg, J.J.M., Verheije, M.H., Kroese, M.V.   +3 more
core  

Retroviral nucleocapsid proteins and DNA strand transfers

Biochimie Open, 2018
An infectious retroviral particle contains 1000-1500 molecules of the nucleocapsid protein (NC) that cover the diploid RNA genome. NC is a small zinc finger protein that possesses nucleic acid chaperone activity that enables NC to rearrange DNA and RNA molecules into the most thermodynamically stable structures usually those containing the maximum ...
René, Brigitte, Mauffret, Olivier, Fossé, Philippe   +2 more
openaire   +2 more sources