Results 81 to 90 of about 3,660,966 (235)

Endowing Flexibility of Alveolar Type II Cells to Recapitulate Development From Lung Bud to Alveoli

Advanced Science, EarlyView.
Adult human alveolar type 2 cells are chemically reprogrammed into expandable alveolar progenitor‐like cells that acquire bud tip‐like features during expansion and form organoids that mature into alveolar‐like structures. These organoids model influenza A virus infection and innate immune responses in vitro, while transplanted cells engraft ...
Hongqian Ma, Yuxin Zhang, Lujia Sun, Hong Jiang, Fan Li, Wenming Liu, Shenao Zhou, Mengting Wang, Weijian Huang, Xu Zhou, Caiyang Chen, Qiuqiu Zhang, Xiaoyan Jin, Feihan Yan, Hongping Wu, Yonghong Yin, Xinling Wang, Hexin Yan, Weifeng Yu   +18 more
wiley   +1 more source

Characterisation of human coronavirus-NL63 nucleocapsid protein [PDF]

, 2016
Coronavirus N is a multifunctional protein that plays an essential role in enhancing the efficiency of virus transcription and assembly. This manuscript reports the analysis of HCoV-NL63 N protein by comparing the amino acid sequences of coronavirus N ...
Tan, Yee-Joo, Fielding, Burtram C., Manasse, Taryn-Lee, Berry, Michael   +3 more
core   +1 more source

The Nucleoprotein and Phosphoprotein of Measles Virus

Frontiers in Microbiology, 2019
Measles virus is a negative strand virus and the genomic and antigenomic RNA binds to the nucleoprotein (N), assembling into a helical nucleocapsid. The polymerase complex comprises two proteins, the Large protein (L), that both polymerizes RNA and caps ...
Serafima Guseva, Sigrid Milles, Martin Blackledge, Rob W. H. Ruigrok   +3 more
doaj   +1 more source

Architecture of the baculovirus nucleocapsid revealed by cryo-EM

Nature Communications, 2023
Baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) has been widely used as a bioinsecticide and a protein expression vector. Despite their importance, very little is known about the structure of most baculovirus proteins.
Xudong Jia, Yuanzhu Gao, Yuxuan Huang, Linjun Sun, Siduo Li, Hongmei Li, Xueqing Zhang, Yinyin Li, Jian He, Wenbi Wu, Harikanth Venkannagari, Kai Yang, Matthew L. Baker, Qinfen Zhang   +13 more
doaj   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Elucidation of the stability and functional regions of the human coronavirus OC43 nucleocapsid protein

, 2009
Human coronavirus OC43 (HCoV-OC43) is one of the causes of the "common cold" in human during seasons of cold weather. The primary function of the HCoV-OC43 nucleocapsid protein (N protein) is to recognize viral genomic RNA, which leads to ...
Hsu, Y.L., Chun-Yu Huang, Hou, M.H., 侯明宏, Wan-Ling Chiang, Yen-Lan Hsu, Ming-Hon Hou, Huang, C.Y., Chiang, W.L.   +8 more
core   +1 more source

IDENTIFICATION OF NOVEL PHOSPHORYLATION SITES IN SARS-CoV-2 NUCLEOCAPSID PROTEIN [PDF]

, 2022
COVID-19, the 2019 disease outbreak, continues to cause severe mortality worldwide. Fast and reliable tests that identify the SARS-CoV-2 virus, which is responsible for causing the COVID-19 disease, are crucial for controlling the spread of the virus ...
Daldegan Rezende, Josie
core  

Zinc-binding properties of Junín virus nucleocapsid protein [PDF]

, 2001
The arenavirus nucleocapsid protein (N) is a highly basic 63 kDa protein with a dual function during the virus life-cycle. First, it is involved in essential steps of genome replication, promoting the synthesis of the full-length antigenomic copy of S ...
Ghiringhelli, P. D., Lozano, Mario E., Albariño, César G., Romanowski, Víctor, Tortorici, María Alejandra   +4 more
core   +2 more sources

An Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir

Advanced Science, EarlyView.
FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun, Rohan Narayan, Santhosh Kambaiah Nagaraj, Rishad Shiraz, Abinaya Kaliappan, Sumandeep Kaur, Ankur Singh, Siva Shanmugam Selvaraj, Gudepalya Renukaiah Rudramurthy, Chakenahalli Naveenkumar, Shridhar Narayanan, Radha Krishan Shandil, Shailly Tomar, Shashank Tripathi   +13 more
wiley   +1 more source

The crystal structure of the Hazara virus nucleocapsid protein [PDF]

BMC Structural Biology, 2015
Hazara virus (HAZV) is a member of the Bunyaviridae family of segmented negative stranded RNA viruses, and shares the same serogroup as Crimean-Congo haemorrhagic fever virus (CCHFV). CCHFV is responsible for fatal human disease with a mortality rate approaching 30 %, which has an increased recent incidence within southern Europe.
Surtees, R, Ariza, A, Punch, EK, Trinh, CH, Dowall, SD, Hewson, R, Hiscox, JA, Barr, JN, Edwards, TA   +8 more
openaire   +5 more sources