Results 131 to 140 of about 10,335 (179)
Nucleolin Overexpression Confers Increased Sensitivity to the Anti-Nucleolin Aptamer, AS1411 [PDF]
Cancer Investigation, 2018 AS1411 is an antiproliferative DNA aptamer, which binds the ubiquitous protein, nucleolin. In this study, we show that constitutive overexpression of nucleolin confers increased sensitivity to the growth inhibitory effects of AS1411. HeLa cells overexpressing nucleolin have an increased growth rate and invasiveness relative to control cells.
Shelia Thomas +2 more
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Structure and functions of nucleolin
Journal of Cell Science, 1999ABSTRACT Nucleolin is an abundant protein of the nucleolus. Nucleolar proteins structurally related to nucleolin are found in organisms ranging from yeast to plants and mammals. The association of several structural domains in nucleolin allows the interaction of nucleolin with different proteins and RNA sequences.
Ginisty, H. +3 more
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The new face of nucleolin in human melanoma
Cancer Immunology, Immunotherapy, 2009 Nucleolin is multifunctional protein mainly present in nucleoli but also detected in cytoplasm and plasma membranes. Extranuclear nucleolin differs from the nuclear form by its glycosylation. Studies on expression of nucleolin in breast cancer suggest a possible association to the metastatic cascade.
Dorota Hoja-Łukowicz +2 more
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A tRF nucleator for Nucleolin in cancer metastasis
Molecular Cell, 2022In this issue of Molecular Cell, Liu et al. (2022) report that 5'-tRFCys, a stress-induced transfer RNA-derived RNA fragment (tRF) derived from the 5' halves of cysteine tRNAs, regulates post-transcriptional gene expression, enabling the survival and lung metastasis formation of breast cancers.
Yichen, Xu, Davide, Ruggero
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Nucleolin: a multiFACeTed protein
Trends in Cell Biology, 2007Nucleolin is an abundant, ubiquitously expressed protein that is found in various cell compartments, especially in the nucleolus, of which it is a major component. This multifunctional protein has been described as being a part of many pathways, from interactions with viruses at the cellular membrane to essential processing of the ribosomal RNA in the ...
Mongelard, Fabien, Bouvet, Philippe
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Morphometrical analysis of nucleolin immunohistochemistry in meningiomas
Acta Neuropathologica, 1996Nucleolin (110 kDa) is a major nucleolar protein in eukaryotic cells and one of the nucleolar organizer region (NOR)-associated proteins. We studied immunohistochemically 32 cases of meningioma, using specific antisera against nucleolin, and analyzed various nucleolin parameters, such as the number of regions and the total area of nucleolin staining ...
Hirofumi Sawa +2 more
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Nucleolin: A Multifunctional Major Nucleolar Phosphoprotein
Critical Reviews in Biochemistry and Molecular Biology, 1998Nucleolin is a major protein of exponentially growing eukaryotic cells where it is present in abundance at the heart of the nucleolus. It is highly conserved during evolution. Nucleolin contains a specific bipartite nuclear localization signal sequence and possesses a number of unusual structural features.
Renu Tuteja, Narendra Tuteja
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Nucleolin is a calcium‐binding protein
Journal of Cellular Biochemistry, 2002AbstractWe have purified a prominent 110‐kDa protein (p110) from 1.6 M NaCl extracts of rat liver nuclei that appears to bind Ca2+. p110 was originally identified by prominent blue staining with ‘Stains‐All’ in sodium dodecyl sulfate–polyacrylamide gels and was observed to specifically bind ruthenium red and 45Ca2+ in nitrocellulose blot overlays.
James S C, Gilchrist +4 more
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Characterization of nucleolin K88 acetylation defines a new pool of nucleolin colocalizing with pre‐mRNA splicing factors [PDF]
FEBS Letters, 2013 Nucleolin and SC35 colocalize by fluorescence microscopy (View interaction)
Tapas Kundu +2 more
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