Results 141 to 150 of about 10,335 (179)
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The roles of nucleolin subcellular localization in cancer
Biochimie, 2015Nucleolin (NCL) is one of the most abundant non ribosomal protein of the nucleolus where it plays a central role in polymerase I transcription. NCL is also found outside of the nucleolus, in the nucleoplasm, cytoplasm as well as on the cell membrane. It acts in all cell compartments to control cellular homeostasis and therefore each cellular pool of ...
Philippe Bouvet +1 more
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Glycosilated nucleolin as marker for human gliomas
Journal of Cellular Biochemistry, 2012AbstractNucleolin is a multifunctional DNA and RNA binding protein involved in regulation of gene transcription, chromatin remodeling, RNA metabolism, and ribosomal RNA synthesis. Nucleolin seems to be over‐expressed in highly proliferative cells and is involved in many aspect of gene expression: DNA recombination and replication, RNA transcription by ...
Annamaria Cimini +2 more
exaly +6 more sources
Nucleolin-RNA interaction modulates rotavirus replication
Journal of Virology, 2023Abstract Rotavirus infection is a leading cause of gastroenteritis in children worldwide, the genome of this virus is composed of eleven segments of dsRNA packed in a triple-layered protein capsid. Here, we investigated the role of nucleolin, a protein with diverse RNA-binding domains, on rotavirus infection.
Jey Hernández-Guzmán +3 more
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Nucleolin in onion cells, identified and localized with anti-hamster nucleolin
2021Trabajo presentado en el 12th European Workshop on the Cell Nucleus, celebrado en Les Diablerets (Suiza) del 02 al 06 de septiembre de 1991.
García-Fernández, Luis F. +2 more
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Functions Of The Histone Chaperone Nucleolin In Diseases
2007Alteration of nuclear morphology is often used by pathologist as diagnostic marker for malignancies like cancer. In particular, the staining of cells by the silver staining methods (AgNOR) has been proved to be an important tool for predicting the clinical outcome of some cancer diseases.
Storck, Sébastien +3 more
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Biology of the Cell, 1998
Electroporation of exponentially growing human larynx epidermoid carcinoma cells (HEp‐2) with a serum against nucleolin, one of the most abundant non‐histone nuclear proteins, has shown, 24 h after electroporation, a significant increase in the size of the nucleolus of these cells compared with normal HEp‐2 cells (non‐electroporated) and electroporated
F, Abadía-Molina +3 more
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Electroporation of exponentially growing human larynx epidermoid carcinoma cells (HEp‐2) with a serum against nucleolin, one of the most abundant non‐histone nuclear proteins, has shown, 24 h after electroporation, a significant increase in the size of the nucleolus of these cells compared with normal HEp‐2 cells (non‐electroporated) and electroporated
F, Abadía-Molina +3 more
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In SituLocalization of Nucleolin in the Plant Nucleolar Matrix
Experimental Cell Research, 1996The analysis of isolated nucleolar matrices from onion cells by light and electron microscopy, 2-D separation of proteins, and confocal microscopy has confirmed the existence of an organized nucleolar matrix with a complex protein composition to which are attached the insoluble processing complexes.
Mínguez Garrido, Ana +1 more
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DNA and Cell Biology, 2003
Nucleolin is a nucleolar phosphoprotein that plays a direct role in ribosome biogenesis. Our aim was to determine how its activity as a growth-promoting factor is coordinated with, if not regulated by, the cell cycle machinery. In serum starting and then rescuing these cells with serum, we found that the protein level did not drop in the same way that ...
Steven K, Kim, Meera, Srivastava
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Nucleolin is a nucleolar phosphoprotein that plays a direct role in ribosome biogenesis. Our aim was to determine how its activity as a growth-promoting factor is coordinated with, if not regulated by, the cell cycle machinery. In serum starting and then rescuing these cells with serum, we found that the protein level did not drop in the same way that ...
Steven K, Kim, Meera, Srivastava
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The Multiple Properties and Functions of Nucleolin
2011Nucleolin, one of the most abundant proteins of the nucleolus is a fascinating protein with multiple proposed functions within and outside the nucleoli. Since its discovery almost 40 years ago, it was proposed that nucleolin is involved in ribosome biogenesis but until recently the molecular mechanisms of this involvement were not known.
Rong Cong, Sadhan Das, Philippe Bouvet
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Kaibogaku zasshi. Journal of anatomy, 2003
Protein phosphorylation and dephosphorylation has been recognized as a key mechanism in cell proliferation, differentiation, and apoptosis in various tissues. Okadaic acid is a potent inhibitor of protein phosphatase type 1 (PP1) and type 2A and induces apoptosis in human osteoblastic Saos-2 and MG63 cells.
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Protein phosphorylation and dephosphorylation has been recognized as a key mechanism in cell proliferation, differentiation, and apoptosis in various tissues. Okadaic acid is a potent inhibitor of protein phosphatase type 1 (PP1) and type 2A and induces apoptosis in human osteoblastic Saos-2 and MG63 cells.
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