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Nucleolin: A Multifunctional Major Nucleolar Phosphoprotein
Critical Reviews in Biochemistry and Molecular Biology, 1998Nucleolin is a major protein of exponentially growing eukaryotic cells where it is present in abundance at the heart of the nucleolus. It is highly conserved during evolution. Nucleolin contains a specific bipartite nuclear localization signal sequence and possesses a number of unusual structural features.
Renu Tuteja, Narendra Tuteja
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Nucleolin: a multiFACeTed protein
Trends in Cell Biology, 2007Nucleolin is an abundant, ubiquitously expressed protein that is found in various cell compartments, especially in the nucleolus, of which it is a major component. This multifunctional protein has been described as being a part of many pathways, from interactions with viruses at the cellular membrane to essential processing of the ribosomal RNA in the ...
Mongelard, Fabien, Bouvet, Philippe
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The lectin-binding pattern of nucleolin and its interaction with endogenous galectin-3 [PDF]
Cellular and Molecular Biology Letters, 2014 Unlike nuclear nucleolin, surface-expressed and cytoplasmic nucleolin exhibit Tn antigen. Here, we show localization-dependent differences in the glycosylation and proteolysis patterns of nucleolin.
Dorota Hoja-Łukowicz +2 more
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The roles of nucleolin subcellular localization in cancer
Biochimie, 2015Nucleolin (NCL) is one of the most abundant non ribosomal protein of the nucleolus where it plays a central role in polymerase I transcription. NCL is also found outside of the nucleolus, in the nucleoplasm, cytoplasm as well as on the cell membrane. It acts in all cell compartments to control cellular homeostasis and therefore each cellular pool of ...
Caroline M Berger, Philippe Bouvet
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Morphometrical analysis of nucleolin immunohistochemistry in meningiomas
Acta Neuropathologica, 1996Nucleolin (110 kDa) is a major nucleolar protein in eukaryotic cells and one of the nucleolar organizer region (NOR)-associated proteins. We studied immunohistochemically 32 cases of meningioma, using specific antisera against nucleolin, and analyzed various nucleolin parameters, such as the number of regions and the total area of nucleolin staining ...
M, Ohkoudo +8 more
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Nucleolin-RNA interaction modulates rotavirus replication
Journal of Virology, 2023Abstract Rotavirus infection is a leading cause of gastroenteritis in children worldwide, the genome of this virus is composed of eleven segments of dsRNA packed in a triple-layered protein capsid. Here, we investigated the role of nucleolin, a protein with diverse RNA-binding domains, on rotavirus infection.
Jey Hernández-Guzmán +3 more
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Biology of the Cell, 1998
Electroporation of exponentially growing human larynx epidermoid carcinoma cells (HEp‐2) with a serum against nucleolin, one of the most abundant non‐histone nuclear proteins, has shown, 24 h after electroporation, a significant increase in the size of the nucleolus of these cells compared with normal HEp‐2 cells (non‐electroporated) and electroporated
F, Abadía-Molina +3 more
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Electroporation of exponentially growing human larynx epidermoid carcinoma cells (HEp‐2) with a serum against nucleolin, one of the most abundant non‐histone nuclear proteins, has shown, 24 h after electroporation, a significant increase in the size of the nucleolus of these cells compared with normal HEp‐2 cells (non‐electroporated) and electroporated
F, Abadía-Molina +3 more
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Functions Of The Histone Chaperone Nucleolin In Diseases
2007Alteration of nuclear morphology is often used by pathologist as diagnostic marker for malignancies like cancer. In particular, the staining of cells by the silver staining methods (AgNOR) has been proved to be an important tool for predicting the clinical outcome of some cancer diseases.
Storck, Sébastien +3 more
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DNA and Cell Biology, 2003
Nucleolin is a nucleolar phosphoprotein that plays a direct role in ribosome biogenesis. Our aim was to determine how its activity as a growth-promoting factor is coordinated with, if not regulated by, the cell cycle machinery. In serum starting and then rescuing these cells with serum, we found that the protein level did not drop in the same way that ...
Steven K, Kim, Meera, Srivastava
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Nucleolin is a nucleolar phosphoprotein that plays a direct role in ribosome biogenesis. Our aim was to determine how its activity as a growth-promoting factor is coordinated with, if not regulated by, the cell cycle machinery. In serum starting and then rescuing these cells with serum, we found that the protein level did not drop in the same way that ...
Steven K, Kim, Meera, Srivastava
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A novel interation of nucleolin with Rad51
Biochemical and Biophysical Research Communications, 2006Nucleolin associates with various DNA repair, recombination, and replication proteins, and possesses DNA helicase, strand annealing, and strand pairing activities. Examination of nuclear protein extracts from human somatic cells revealed that nucleolin and Rad51 co-immunoprecipitate.
Ananya De +6 more
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