Results 111 to 120 of about 146,762 (298)
Controlling Topology of a Telomeric G‐quadruplex DNA With a Chemical Cross‐link
Chemistry – A European Journal, EarlyView.Thermodynamically stable G‐quadruplex (G4) DNA: Chemical cross‐linking between distant nucleotides led to formation of G4‐DNA that is stable in the presence of complementary DNA. This methodology can be used to reliably form G4s within DNA fibers for subsequent structural studies of G4‐protein interactions.
Bruce Chilton +4 more
wiley +1 more source
NUCLEOSIDE PHOSPHATASE ACTIVITIES IN RAT CARDIAC MUSCLE [PDF]
, 1965 Edward Essner +2 more
openalex +1 more source
Tailored Watson–Crick Pairing Partners for Xanthosine in RNA
Chemistry – A European Journal, EarlyView.RNAs with kappa‐xanthosine (K–X) or 2‐iminocytidine‐xanthosine (2imC–X) base pairs form stable double helices that have higher melting temperatures than those of the A–U or G–U references. Access to these novel 2imC‐modified RNAs is possible through the mild, selective chemical conversion of 2‐thiocytidine RNA precursors.
Stefan Mair +5 more
wiley +1 more source
Efficacy of DNA Intercalator‐Conjugated Triplex‐Forming Oligonucleotide as Anticancer Agent
ChemMedChem, Accepted Article.A triplex‐forming oligonucleotide (TFO) can form a sequence‐specific triple helix via Hoogsteen hydrogen bonding to polypurine tracts within a major groove side of a DNA duplex. Triplex formation can induce a double‐strand break, and this phenomenon at the amplified gene loci can selectively induce the cell death of cancer cells with specific gene ...
Haruki Toyama +5 more
wiley +1 more source
Advances in Isotope Labeling for Solution Nucleic Acid Nuclear Magnetic Resonance Spectroscopy
ChemPlusChem, EarlyView.Recent advances in the field of nucleic acid nuclear magnetic resonance (NMR) are presented. Stable isotope labeling protocols and new approaches to segmentally label nucleic acid with NMR‐active residues are summarized. The novel methods will have a strong impact on the future of nucleic acid NMR and the characterization of structure and dynamics of ...
Stefan Hilber +3 more
wiley +1 more source
Influence of some mononucleotides and their corresponding nucleosides on the metabolism of carbohydrates in the isolated rat diaphragm muscle [PDF]
, 1965 A Beloff-Chain +7 more
openalex +1 more source
Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics
Clinical Pharmacology &Therapeutics, EarlyView.The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou +6 more
wiley +1 more source