Results 221 to 230 of about 340,942 (336)

Microneedles for the treatment of migraine and orofacial pain: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Background Migraine is a common neurological disorder and a primary headache condition. Despite its central origin, migraine pain may be referred to the orofacial region via trigeminal pathways, resulting in phenotypic overlap with other orofacial pain (OFP) conditions.
Baicheng Cao, Qiuyi Chen, Yuhan Liu, Ruozhou Wu, Bin Li, Qing Cai, Lu Liu   +6 more
wiley   +1 more source

Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites. [PDF]

Chemistry
Monfret O, Liu D, Louis M, Rebei S, Urban D, Bourdreux Y, Mouray E, Grellier P, Doisneau G, Guianvarc'h D.   +9 more
europepmc   +1 more source

Suppression of Indoleamine 2,3‐Dioxygenase Enhances Immune Responses to the Therapeutic Vaccine for Chronic Hepatitis B

Hepatology Research, EarlyView.
Indoleamine 2,3‐dioxygenase (IDO) activity modulates immune responses to the therapeutic HBV vaccine NASVAC. Genetic or pharmacological suppression of IDO enhanced vaccine efficacy in mice, and lower serum kynurenine levels predicted favorable responses in humans, suggesting IDO as both a therapeutic target and a biomarker.
Yohei Shirakami, Soranobu Ninomiya, Takayasu Ideta, Ayumu Kanbe, Toshihide Maeda, Daisuke Minowa, Daisuke Taguchi, Masaya Kubota, Hiroyasu Sakai, Kenji Imai, Yasuko Yamamoto, Hiroyasu Ito, Kuniaki Saito, Osamu Yoshida, Yoichi Hiasa, Masahito Shimizu   +15 more
wiley   +1 more source

Adipose tissue releases nucleosides. [PDF]

Am J Physiol Cell Physiol
Zhang J, Le T, Ruiz-Torres V, Cohen M, Paharkova V, Abt E, Alnajjar HS, Tan J, Rashid K, Jones AE, Ball AB, Divakaruni AS, Paszkiewicz RL, Bandaru P, Mack JJ, Ashby JW, Kim J, Li G, Radu CG, Mittelman SD.   +19 more
europepmc   +1 more source

Effectiveness and safety of two‐drug regimens containing an integrase inhibitor and reverse transcriptase inhibitor in a cohort of virologically suppressed people with HIV: Data from the COMBINE‐2 study

HIV Medicine, EarlyView.
Abstract Objectives This study assessed real‐world effectiveness and safety of switching to dual therapy regimens consisting of an integrase inhibitor (INSTI), and reverse transcriptase inhibitor (RTI), among suppressed people living with HIV in Europe.
Cristina Mussini, Cassidy Henegar, Lambert Assoumou, Stephane de Wit, Margaret Johnson, Eugenia Quiros‐Roldan, Chris Kenyon, Colin Deschanvres, David Zucman, Frank Post, Roya Movahedi, Laura Comi, Julie Fox, Geoffrey Liegeon, Charlotte Martin, Jonathan Edwards, Giorgio Tiecco, Marc Delforge, Leigh Ragone, Bryn Jones, Jean van Wyk, Michael Aboud, Carl Fletcher, Anton Pozniak, Vani Vannappagari   +24 more
wiley   +1 more source

A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500 per cubic millimeter. AIDS Clinical Trials Group Study 175 Study Team.

New England Journal of Medicine, 1996
Scott M. Hammer, D. Katzenstein, M. Hughes, Holly Gundacker, R. T. Schooley, Richard H. Haubrich, W. K. Henry, Michael M. Lederman, J. P. Phair, Manette T. Niu, M. Hirsch, Thomas C. Merigan   +11 more
semanticscholar   +1 more source

Psychological responses to interval and continuous exercise in people living with HIV: A single‐blind, counterbalanced, crossover study

HIV Medicine, EarlyView.
Abstract Aim This study compared acute psychological responses to a single session of low‐volume high‐intensity interval exercise (HIIE‐LV), high‐volume high‐intensity interval exercise (HIIE‐HV), and moderate‐intensity continuous exercise (MICE) in people living with HIV, and healthy controls using a randomized, counterbalanced crossover design ...
Phelipe Wilde, Victor S. de Queiros, Jason R. Jaggers, Angelo Sabag, Júlio M. Alves, Elaine Fernandes, Roberto F. C. Rocha, Paulo F. de Almeida‐Neto, Ronaldo Vagner Thomatieli‐Santos, Paulo Moreira Silva Dantas   +9 more
wiley   +1 more source

Pharmacokinetics of Dolutegravir, nucleoside analogues, and intracellular metabolites using plasma separation cards: A comparative analysis with traditional sampling methods in healthy volunteers. [PDF]

PLoS One
Thompson B, Else LJ, Dickinson L, Edick S, Zyhowski A, Ho K, Meyn L, Dilly-Penchala S, Shaw V, McGowan I, Khoo S, Brand RM.   +11 more
europepmc   +1 more source

The GABA transaminase, ABAT, is essential for mitochondrial nucleoside metabolism.

Cell Metabolism, 2015
A. Besse, Ping Wu, Francesco Bruni, T. Donti, B. Graham, W. Craigen, R. Mcfarland, P. Moretti, S. Lalani, K. Scott, Robert W. Taylor, P. Bonnen   +11 more
semanticscholar   +1 more source

Immune non‐response despite effective antiretroviral therapy in people living with HIV: A review of potential mechanisms, biomarkers and therapeutic approaches

HIV Medicine, EarlyView.
Abstract Introduction A proportion of people living with HIV (PLWH) fail to restore their CD4 count or their CD4/CD8 ratio despite effective antiretroviral therapy (ART). PLWH with immune non‐response (INR) are at a higher risk of both AIDS and non‐AIDS events. The underlying mechanisms of INR remain unclear.
Charlotte Silvestre, Antoine Gross, Alain Makinson   +2 more
wiley   +1 more source