Results 221 to 230 of about 235,474 (365)

Biochemical Studies of the Nucleoside Analogue, Formycin

open access: hybrid, 1969
David C. Ward   +4 more
openalex   +1 more source

Pharmacokinetics of Atorvastatin and Metformin after Coadministration with Islatravir in Healthy Adults

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Islatravir, a deoxyadenosine analog that inhibits HIV‐1 replication by multiple mechanisms of action, including reverse transcriptase translocation inhibition, is being developed for use in HIV‐1 treatment. People living with HIV often have comorbidities, such as dyslipidemia or type 2 diabetes mellitus, necessitating long‐term concomitant ...
Jacqueline B. McCrea   +8 more
wiley   +1 more source

Unmasking the halide effect in diastereoselective Grignard reactions applied to C4´ modified nucleoside synthesis. [PDF]

open access: yesNat Commun
Muir G   +10 more
europepmc   +1 more source

In Vitro and Clinical Evaluations of UGT1A1‐, P‐gp‐, OATP1B1‐, and BCRP‐Mediated Drug–Drug Interactions of Belumosudil, a Potent ROCK2 Inhibitor

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Belumosudil is an oral selective rho‐associated coiled‐coil containing protein kinase 2 inhibitor, approved as a treatment for chronic graft‐versus‐host disease. Prior clinical studies demonstrated that coadministration with strong CYP3A4 inducers or proton pump inhibitors requires dose modification of belumosudil.
Olivier Schueller   +4 more
wiley   +1 more source

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