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Synthesis and Antiviral Evaluation of Novel Cyclopropyl Nucleosides, Phosphonate Nucleosides and Phosphonic Acid Nucleosides [PDF]
Archiv der Pharmazie, 2006 AbstractNovel phenyl‐branched cyclopropyl nucleosides, phosphonates, and phosphonic acid analogues were designed and synthesized as potential antiviral agents. Coupling of the mesylate 10 with natural bases (U, T, C, A) and desilylation/hydrolysis afforded a series of novel cyclopropyl nucleosides 15–18.
Chang Hyun Oh, Joon Hee Hong
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Pyrazolylboratozinc Complexes of Nucleosides and Nucleoside Analogues
European Journal of Inorganic Chemistry, 2003AbstractAttachment of deprotonated nucleosides or of alkylated nucleobases, as their analogues, to zinc was achieved by condensation reactions between TpZn‐OH complexes and nucleobase derivatives. Pyrazolylboratozinc complexes with derivatives of uracil, thymine, guanine, xanthine and hypoxanthine were obtained and characterized by structure ...
Heinrich Vahrenkamp, Dirk Badura
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ChemInform Abstract: Glycosylation of Nucleosides.
ChemInform, 2016AbstractOptimized conditions for the O‐glycosylation of nucleoside hydroxyls are developed.
Spencer Knapp, Yonglian Zhang
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The HCV NS5B Nucleoside and Non-Nucleoside Inhibitors
Clinics in Liver Disease, 2011This article introduces one of the most diverse classes of direct-acting antivirals for hepatitis C, the nucleoside and non-nucleoside NS5B polymerase inhibitors. Through a systematic review of the published literature, we describe their structure, mechanism of action, issues with resistance, and clinical effectiveness shown in the latest clinical ...
Eric Lawitz, Fernando E. Membreno
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Journal of the Chemical Society C: Organic, 1971
A new route for the preparation of 4-amino-1-(β-D-ribofuranosyl)pyrazolo[3,4-d]pyrimidine (5)(6-azatubercidin) is described. The anomeric configuration of the product has been established unequivocally for the first time by cyclonucleoside formation, and agrees with previously reported anomeric assignments.
Leroy B. Townsend, Ganapthi R. Revankar
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A new route for the preparation of 4-amino-1-(β-D-ribofuranosyl)pyrazolo[3,4-d]pyrimidine (5)(6-azatubercidin) is described. The anomeric configuration of the product has been established unequivocally for the first time by cyclonucleoside formation, and agrees with previously reported anomeric assignments.
Leroy B. Townsend, Ganapthi R. Revankar
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The role of nucleoside transporters in cancer chemotherapy with nucleoside drugs
Cancer and Metastasis Reviews, 2007Nucleoside analogs are important components of treatment regimens for various malignancies. Nucleoside-specific membrane transporters mediate plasma membrane permeation of physiologic nucleosides and most nucleoside analogs, for which the initial event is cellular conversion of nucleosides to active agents.
Stephen A. Baldwin +9 more
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Carbohydrate Research, 2000
The synthesis and biological activity of deoxyfluoro nucleosides are reviewed.
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The synthesis and biological activity of deoxyfluoro nucleosides are reviewed.
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Nucleosides XXXVI. Transformation of arabinopyrimidine nucleosides
Tetrahedron Letters, 1966Robert J. Cushley +2 more
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Active transport of nucleosides and nucleoside drugs
Biochemical Society Transactions, 1989Timothy C. Williams +3 more
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