Results 31 to 40 of about 340,942 (336)

Synthesis of 1,4-Disubstituted Mono and Bis-triazolocarbo-acyclonucleoside Analogues of 9-(4-Hydroxybutyl)guanine by Cu(I)-Catalyzed Click Azide-Alkyne Cycloaddition [PDF]

, 2011
A series of novel mono-1,2,3-triazole and bis-1,2,3-triazole acyclonucleoside analogues of 9-(4-hydroxybutyl)guanine was prepared via copper(I)-catalyzed 1,3-dipolar cycloaddition of N-9 propargylpurine, N-1-propargylpyrimidines/as-triazine with the ...
Engels, Joachim W., Krim, Jamal, Taourirte, Mohamed   +2 more
core   +2 more sources

Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

Journal of Experimental Medicine, 2018
T follicular helper (Tfh) cells are required to develop germinal center (GC) responses and drive immunoglobulin class switch, affinity maturation, and long-term B cell memory.
N. Pardi, Michael J. Hogan, Martin S Naradikian, Kaela Parkhouse, D. Cain, Letitia Jones, M. A. Moody, H. Verkerke, A. Myles, Elinor Willis, C. Labranche, D. Montefiori, Jenna L. Lobby, K. Saunders, H. Liao, B. Korber, Laura L. Sutherland, R. Scearce, P. Hraber, I. Tombácz, Hiromi Muramatsu, Houping Ni, D. A. Balikov, Charles Li, B. Mui, Ying K. Tam, F. Krammer, K. Karikó, P. Polacino, L. Eisenlohr, T. D. Madden, M. Hope, M. Lewis, Kelly K. Lee, Shiu-Lok Hu, S. Hensley, M. Cancro, B. Haynes, D. Weissman   +38 more
semanticscholar   +1 more source

52-week efficacy and safety of telbivudine with conditional tenofovir intensification at week 24 in HBeAg-positive chronic Hepatitis B [PDF]

, 2013
Background and Aims: The Roadmap concept is a therapeutic framework in chronic hepatitis B for the intensification of nucleoside analogue monotherapy based on early virologic response.
Aldo Trylesinski, AS Levey, AS Lok, BJ McMahon, CJ Chen, CL Lai, DJ Tenney, DJ Tenney, DW Cockcroft, EB Keeffe, Eduardo Fassio, Fernando Bessone, H Izzedine, H Mommeja-Marin, H Yang, Henry L. Y. Chan, HL Chan, Hugo Cheinquer, Javier R. Lama, JD Jia, Jorge Daruich, KL Andersson, Liver European Association For The Study Of The, MF Yuen, MF Yuen, Mário G. Pessôa, N Leung, P Marcellin, Piyawat Komolmit, Rashidkhan Pathan, RD Cooper, RG Gish, S Mauss, S Zeuzem, Stefan Zeuzem, Suzane K. Ono, Tawesak Tanwandee, Teerha Piratvisuth, Wattana Sukeepaisarnjaroen, YF Liaw, YF Liaw, Yuhong Dong   +41 more
core   +10 more sources

Carbamate-Based Bolaamphiphile as Low-Molecular-Weight Hydrogelators

Gels, 2016
A new bolaamphiphile analog featuring carbamate moieties was synthesized in six steps starting from thymidine. The amphiphile structure exhibits nucleoside-sugar polar heads attached to a hydrophobic spacer via carbamate (urethane) functions.
Laurent Latxague, Alexandra Gaubert, David Maleville, Julie Baillet, Michael A. Ramin, Philippe Barthélémy   +5 more
doaj   +1 more source

Biogenesis of mitochondrial porin [PDF]

, 1990
We review here the present knowledge about the pathway of import and assembly of porin into mitochondria and compare it to those of other mitochondrial proteins.
A. Grossmann, A. L. Horwich, B. L. Geller, B. Schmidt, C. Smagula, C. Witte, C. Zwizinski, C. Zwizinski, D. M. Kolansky, D. Roise, D. Vestweber, D. W. Nicholson, E. C. Hurt, E. C. Hurt, E. C. Hurt, E. C. Hurt, F.-U. Hartl, G. Hallermayer, G. Hawlitschek, G. Heijne von, G. S. Adrian, H. Aquila, H. Aquila, H. Freitag, H. Freitag, H. Freitag, H. Murakami, H. Ono, H. Wiech, J. A. Rothblatt, K. Mihara, K. Mihara, L. Chen, M. Colombini, M. Eilers, M. Eilers, M. G. Waters, M. Linden, M. Mueckler, M. P. Yaffe, M. Schleyer, M. Schleyer, M. Schwaiger, M. Y. Cheng, M. Yang, N. Pfanner, N. Pfanner, N. Pfanner, N. Pfanner, N. Pfanner, N. Pfanner, N. Pflanner, R. A. Pollock, R. A. Stuart, R. Benz, R. E. Jensen, R. J. Deshaies, R. Jaenicke, R. Kleene, R. Kleene, R. Pfaller, R. Pfaller, R. Pfaller, R. Pfaller, R. Zimmermann, S. Hamajima, S. M. Gasser, S. M. Gasser, T. Hase, T. Imanaka, U. I. Flügge, W. Hansen, W. J. Chirico, W. Neupert, W.-J. Chen   +74 more
core   +1 more source

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses

Scientific Reports, 2017
GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed therapeutic efficacy in a non-human primate model of Ebola virus infection.
Michael K. Lo, R. Jordan, A. Arvey, J. Sudhamsu, P. Shrivastava-Ranjan, Anne L. Hotard, M. Flint, L. McMullan, D. Siegel, M. Clarke, R. Mackman, H. Hui, M. Perron, A. Ray, T. Cihlář, S. Nichol, C. Spiropoulou   +16 more
semanticscholar   +1 more source

Determination of total potentially available nucleosides in bovine milk [PDF]

, 2010
Bovine colostrum and milk samples were collected from two herds over the course of the first month post-partum, pooled for each herd by stage of lactation and total potentially available nucleosides were determined.
Gill, Brendon D., Indyk, Harvey E., Manley-Harris, Merilyn   +2 more
core   +2 more sources

Nucleoside analogues for the treatment of coronavirus infections

Current Opinion in Virology, 2019
Highlights • Coronaviruses (CoV) represent current and future risk for pandemic zoonotic infections.• Nucleoside analogues are highly active across multiple virus families.• CoVs encode a proofreading exoribonuclease that opposes inhibition by many ...
A. Pruijssers, M. Denison
semanticscholar   +1 more source

Adenosine as a signaling molecule in the retina: biochemical and developmental aspects

Anais da Academia Brasileira de Ciências, 2002
The nucleoside adenosine plays an important role as a neurotransmitter or neuromodulator in the central nervous system, including the retina. In the present paper we review compelling evidence showing that adenosine is a signaling molecule in the ...
ROBERTO PAES-DE-CARVALHO
doaj   +1 more source

Identification of a Biosynthetic Gene Cluster Responsible for the Production of a New Pyrrolopyrimidine Natural Product—Huimycin

Biomolecules, 2020
Pyrrolopyrimidines are an important class of natural products with a broad spectrum of biological activities, including antibacterial, antifungal, antiviral, anticancer or anti-inflammatory.
Hui Shuai, Maksym Myronovskyi, Suvd Nadmid, Andriy Luzhetskyy   +3 more
doaj   +1 more source