Results 31 to 40 of about 313,454 (314)
Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy [PDF]
, 2017 Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Ali, Juma A.M. +7 more
core +2 more sources
GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses
Scientific Reports, 2017 GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed therapeutic efficacy in a non-human primate model of Ebola virus infection.
Michael K. Lo +16 more
semanticscholar +1 more source
Biomolecules, 2020 Molecular modeling has contributed to drug discovery for purinergic GPCRs, including adenosine receptors (ARs) and P2Y receptors (P2YRs). Experimental structures and homology modeling have proven to be useful in understanding and predicting structure ...
Veronica Salmaso, Kenneth A. Jacobson
doaj +1 more source
Mathematical model of immune response to hepatitis B [PDF]
J. Theor. Biol. 447, 98-110 (2018), 2018 A new detailed mathematical model for dynamics of immune response to hepatitis B is proposed, which takes into account contributions from innate and adaptive immune responses, as well as cytokines. Stability analysis of different steady states is performed to identify parameter regions where the model exhibits clearance of infection, maintenance of a ...
arxiv +1 more source
Indolylarylsulfones, a fascinating story of highly potent human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors [PDF]
, 2018 Indolylarylsulfones are a potent class of human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors. In this review, the structure activity relationship (SAR) studies to improve the profile of sulfone L-737,126 discovered by ...
Famiglini, V., Silvestri, R.
core +1 more source
مجله علمی دانشگاه علوم پزشکی کردستان, 2021 Background and Aim: Regular exercise and proper exercise programs contribute to improvement of physiological function and improve aerobic capacity, blood absorption, and adequate oxygen supply for the brain and muscles.
mohammad dehafarin, farah nameni
doaj
Adenosine as a signaling molecule in the retina: biochemical and developmental aspects
Anais da Academia Brasileira de Ciências, 2002 The nucleoside adenosine plays an important role as a neurotransmitter or neuromodulator in the central nervous system, including the retina. In the present paper we review compelling evidence showing that adenosine is a signaling molecule in the ...
ROBERTO PAES-DE-CARVALHO
doaj +1 more source
Nucleic Acid Sensing by Toll-Like Receptors in the Endosomal Compartment
Frontiers in Immunology, 2022 Toll-like receptors (TLRs) respond to pathogen constituents, such as microbial lipids and nucleic acids (NAs). TLRs recognize NAs in endosomal compartments.
Kensuke Miyake +5 more
doaj +1 more source
A composite model for DNA torsion dynamics [PDF]
Phys. Rev. E75 (2007), 021919, 2006 DNA torsion dynamics is essential in the transcription process; a simple model for it, in reasonable agreement with experimental observations, has been proposed by Yakushevich (Y) and developed by several authors; in this, the DNA subunits made of a nucleoside and the attached nitrogen bases are described by a single degree of freedom. In this paper we
arxiv +1 more source
Focus on chirality of HIV-1 non-nucleoside reverse transcriptase inhibitors [PDF]
, 2016 Chiral HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are of great interest since one enantiomer is often more potent than the corresponding counterpart against the HIV-1 wild type (WT) and the HIV-1 drug resistant mutant strains.
Famiglini, Valeria, Silvestri, Romano
core +2 more sources