Results 41 to 50 of about 41,396 (291)
Chemical investigation of light induced DNA bipyrimidine damage and repair [PDF]
, 2011 In all organisms, genetic information is stored in DNA and RNA. Both of these macromolecules are damaged by many exogenous and endogenous events, with UV irradiation being one of the major sources of damage.
Carell, Thomas +2 more
core +1 more source
Veterinary Sciences, 2021 Feline infectious peritonitis (FIP) is a fatal disease caused by feline coronavirus or its variant, referred to as the FIP virus. Recently, favorable treatment outcomes of the anti-viral drug Mutian® Xraphconn (Mutian X) were noted in cats with FIP. Thus,
Masato Katayama, Yukina Uemura
doaj +1 more source
Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) [PDF]
, 2019 This review focuses on the use of oxadiazoles as translational readthrough-inducing drugs (TRIDs) to rescue the functional full-length protein expression in mendelian genetic diseases caused by nonsense mutations.
Campofelice A. +6 more
core +1 more source
Pteridines, 1993 The chemical syntheses of 6,7-(α-pyridyl)-1-(2,3,5-tri-O-benzoy-β-D-ribofuranosyl)-lumazine (6) and the corresponding free nucleoside 7 are described. Thiation of 6 with P4S10 gave a salt type adduct derivative of 4-thiolumazine 8 which afforded the free
Al-Masoudi Najim AL. +1 more
doaj +1 more source
Virtual screening for NS5B inhibitors of Hepatitis C virus [PDF]
, 2012 Hepatitis C Virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at a risk of developing significant morbidity and mortality.
Achuthsankar S. Nair +2 more
core +2 more sources
Data for the morphometric characterization of NT2-derived postmitotic neurons
Data in Brief, 2016 NTERA2/D1 human teratocarcinoma progenitors induced to differentiate into postmitotic neurons by either long-term treatment with retinoic acid or short-term treatment with the nucleoside analog cytosine β-D-arabinofuranoside were subjected to ...
Imanol González-Burguera +6 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2023 Gastrointestinal malignancies are common digestive system tumor worldwide. Nucleoside analogues have been widely used as anticancer drugs for the treatment of a variety of conditions, including gastrointestinal malignancies.
Xingxing Xu +4 more
doaj +1 more source
Regulated mitochondrial DNA replication during oocyte maturation is essential for successful porcine embryonic development. [PDF]
, 2006 Cellular ATP is mainly generated through mitochondrial oxidative phosphorylation, which is dependent on mitochondrial DNA (mtDNA). We have previously demonstrated the importance of oocyte mtDNA for porcine and human fertilization.
Alexander, Jan +26 more
core +6 more sources
FEBS Open Bio, 2015 Mycoplasmas may colonize tumor tissue in patients. The cytostatic activity of gemcitabine was dramatically decreased inMycoplasma hyorhinis‐infected tumor cell cultures compared with non‐infected tumor cell cultures.
Johan Vande Voorde +3 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source