Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology
Nature Communications, 2017 Masitinib is a protein kinase inhibitor that sensitises refractory pancreatic adenocarcinoma cells to treatment with the nucleoside analog gemcitabine.
Kahina Hammam +18 more
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Comprehensive investigation of HBV-related hepatocellular carcinoma and choice of anti-HBV therapy
Biosafety and Health, 2021 Chronic hepatitis B virus (HBV) infection is a global public health problem, which can cause chronic hepatitis, liver cirrhosis, hepatocellular carcinoma (HCC), and other diseases.
Huihui Lu +6 more
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Lamivudine and Entecavir for Acute Hepatitis B: A Systematic Review and Meta-Analysis
Viruses, 2023 Background. Acute hepatitis B infection is associated with severe liver disease and chronic sequelae in some cases. The purpose of this review was to determine the efficacy of nucleoside analogues (NA) (lamivudine versus entecavir) compared to placebo or
Cesar Henriquez-Camacho +5 more
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Electron collisions with biomolecules [PDF]
, 2008 We report on results of recent studies of collisions of low-energy electrons with nucleobases and other DNA constituents. A particular focus of these studies has been the identification and characterization of resonances that play a role in electron ...
McKoy, Vincent, Winstead, Carl
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Polyphosphate Nucleosides of Purine Analogues
Journal of Biological Chemistry, 1959 (Received for publication, November 17, 1958) To test the hypothesis that carcinostatic purine and pyrimi- dine analogues exert their effects at the nucleotide level, we have undertaken the preparation and study of nucleotides, including coenzymes, which contain analogues in place of the natural bases.
J L, WAY, J L, DAHL, R E, PARKS
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A sequential direct arylation/Suzuki-Miyaura cross-coupling transformation of unprotected 2 '-deoxyadenosine affords a novel class of fluorescent analogues [PDF]
, 2010 Novel rigid 8-biaryl-2'-deoxyadenosines with tuneable fluorescent properties can be accessed by an efficient sequential catalytic Pd-0-coupling ...
Baumann, C.G. +3 more
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Prospects of using the nucleoside analogue riamilovir in patients with SARS-CoV-2 infection
Терапевтический архив, 2022 Aim. To evaluate clinical efficacy of nucleoside analogues in therapy of moderate COVID-19 in in-patients. Materials and methods. Retrospective processing of 108 completed clinical cases with moderate novel coronavirus disease was carried out for the ...
Oleg V. Maltsev +4 more
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Human immunodeficiency virus rebound after suppression to < 400 copies/mL during initial highly active antiretroviral therapy regimens, according to prior nucleoside experience and duration of suppression [PDF]
, 2002 This study evaluated 1433 human immunodeficiency virus (HIV)-infected patients starting highly active antiretroviral therapy (HAART), 409 (28%) of whom had prior nucleoside experience and achieved an HIV load of
Bickel, M +11 more
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Beilstein Journal of Organic Chemistry, 2017 The racemic synthesis of new carbocyclic nucleoside methylphosphonate analogues bearing purine bases (adenine and guanine) was accomplished using bio-sourced furfuryl alcohol derivatives. All compounds were prepared using a Mitsunobu coupling between the
Bemba Sidi Mohamed +2 more
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Longitudinal profile of plasma pregenomic RNA in patients with chronic hepatitis B infection on long-term nucleoside analogues and its interaction with clinical parameters [PDF]
Clinical and Molecular HepatologyBackground/Aims Plasma pregenomic hepatitis B virus RNA (pgRNA) is a novel biomarker in chronic hepatitis B infection (CHB). We aimed to describe the longitudinal profile of pgRNA and factors influencing its levels in CHB patients on nucleoside analogue (
Lung-Yi Mak +8 more
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