Efficient Biocatalytic Synthesis of Dihalogenated Purine Nucleoside Analogues Applying Thermodynamic Calculations [PDF]
, 2020 The enzymatic synthesis of nucleoside analogues has been shown to be a sustainable and efficient alternative to chemical synthesis routes. In this study, dihalogenated nucleoside analogues were produced by thermostable nucleoside phosphorylases in ...
Giessmann, Robert T. +9 more
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Rapid Resolution of Non-Effusive Feline Infectious Peritonitis Uveitis with an Oral Adenosine Nucleoside Analogue and Feline Interferon Omega. [PDF]
Viruses, 2020 Addie DD +3 more
europepmc +2 more sources
BMC Cancer, 2020 Background Cytarabine (ara-C) is the major drug for the treatment of acute myeloid leukemia (AML), but cellular resistance to ara-C is a major obstacle to therapeutic success.
Rie Nishi +5 more
doaj +1 more source
Synthesis of New Fructo – Nucleoside Analogue Derivatives [PDF]
Kirkuk Journal of Science, 2011 Tow types of nucleoside derivatives have been synthesized. To prepare the first type 1′,3′ ,4′,6′ -Tetra-O-benzoyl-β-D-fructo furanose (F1)with a free hydroxyl group at position-2′ was chosen as the Chiron.
Nadia Q. Haj, Mohsin O. Mohammad
doaj +1 more source
Nucleoside Analogues as Antibacterial Agents [PDF]
Frontiers in Microbiology, 2019 The rapid increase in antibiotic-resistant bacteria has emphasized the urgent need to identify new treatments for bacterial infections. One attractive approach, reducing the need for expensive and time-consuming clinical trials, is to repurpose existing clinically approved compounds for use as antibacterial agents.
Jessica M. Thomson, Iain L. Lamont
openaire +3 more sources
Biological phosphorylation of an Unnatural Base Pair (UBP) using a Drosophila melanogaster deoxynucleoside kinase (DmdNK) mutant. [PDF]
PLoS ONE, 2017 One research goal for unnatural base pair (UBP) is to replicate, transcribe and translate them in vivo. Accordingly, the corresponding unnatural nucleoside triphosphates must be available at sufficient concentrations within the cell. To achieve this goal,
Fei Chen +7 more
doaj +1 more source
Molecules, 2021 Nucleoside and nucleotide analogues are essential antivirals in the treatment of infectious diseases such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), herpes simplex virus (HSV), varicella-zoster virus (VZV ...
Guangdi Li +5 more
doaj +1 more source
Nucleoside Analogues and Mitochondrial Toxicity [PDF]
Clinical Infectious Diseases, 2004 An evaluation of the US Food and Drug Administration's Adverse Event Reporting System identified that patients coinfected with human immunodeficiency virus and chronic hepatitis C virus who were treated with a regimen of ribavirin and didanosine, with or without stavudine, were at increased risk for events associated with mitochondrial toxicity ...
Russell, Fleischer +2 more
openaire +2 more sources
Innovative Agents for Actinic Keratosis and Nanocarriers Enhancing Skin Penetration [PDF]
, 2010 Actinic keratosis and cutaneous squamous cell carcinoma are of increasing importance with aging and increased ultraviolet light exposure in Western societies. Efficient and well-tolerated therapy is still a matter of concern.
Höltje, H.-D. +3 more
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Expanding a fluorescent RNA alphabet: synthesis, photophysics and utility of isothiazole-derived purine nucleoside surrogates. [PDF]
, 2017 A series of emissive ribonucleoside purine mimics, all comprised of an isothiazolo[4,3-d]pyrimidine core, was prepared using a divergent pathway involving a key Thorpe-Ziegler cyclization.
Fin, Andrea +2 more
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