Results 1 to 10 of about 41,396 (291)

Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells. [PDF]

J Exp Clin Cancer Res, 2021
Background SAMHD1 mediates resistance to anti-cancer nucleoside analogues, including cytarabine, decitabine, and nelarabine that are commonly used for the treatment of leukaemia, through cleavage of their triphosphorylated forms. Hence, SAMHD1 inhibitors
Rothenburger T, Thomas D, Schreiber Y, Wratil PR, Pflantz T, Knecht K, Digianantonio K, Temple J, Schneider C, Baldauf HM, McLaughlin KM, Rothweiler F, Bilen B, Farmand S, Bojkova D, Costa R, Ferreirós N, Geisslinger G, Oellerich T, Xiong Y, Keppler OT, Wass MN, Michaelis M, Cinatl J.   +23 more
europepmc   +2 more sources

Hepatitis B-Associated Symptomatic Iron Overload, with Complete Resolution after Nucleoside Analogue Treatment. [PDF]

Case Rep Gastrointest Med, 2021
Symptomatic iron overload and hyperferritinemia are rarely mentioned as complications of chronic hepatitis B infection. We report a case of a 70-year-old woman who presented with symptoms of iron overload including aches in the calves, fatigue, poor ...
Tey TT, Yiu R, Leow WQ.
europepmc   +2 more sources

A Pseudouridine Isoxazolidinyl Nucleoside Analogue Structural Analysis: A Morphological Approach. [PDF]

Molecules, 2018
An in silico study has been conducted upon (3′RS,5′SR)-5-[2′-benzyl-5′-hydroxymethyl-1′,2′-isoxazolidin-3′-yl]uracil through a molecular dynamics/docking approach that highlights its potential inhibitory activity upon the wild-type pseudouridine 5 ...
Floresta G, Pistarà V, Christensen KE, Amata E, Marrazzo A, Gentile D, Rescifina A, Punzo F.   +7 more
europepmc   +2 more sources

Soluble programmed cell death-1 predicts hepatocellular carcinoma development during nucleoside analogue treatment. [PDF]

Sci Rep, 2022
Soluble immune checkpoint molecules are emerging novel mediators of immune regulation. However, it is unclear whether soluble immune checkpoint proteins affect the development of hepatocellular carcinoma (HCC) during nucleos(t)ide analogue (NA) treatment
Kozuka R, Enomoto M, Dong MP, Hai H, Thuy LTT, Odagiri N, Yoshida K, Kotani K, Motoyama H, Kawamura E, Hagihara A, Fujii H, Uchida-Kobayashi S, Tamori A, Kawada N.   +14 more
europepmc   +2 more sources

Checkpoint-Dependent Sensitivities to Nucleoside Analogues Uncover Specific Patterns of Genomic Instability. [PDF]

Curr Issues Mol Biol
Nucleoside analogues are used as drugs and as labels in laboratory-based research. However, the effect of different nucleoside analogue mechanism(s) on cell sensitivity or mutagenesis is unclear.
Kagalwala ZB, Chhipa MA, Kianfard Z, Karam E, Magalage SP, Sabatinos SA.   +5 more
europepmc   +2 more sources

Nucleoside analogue EIDD-1931 in the treatment of naturally occurring feline infectious peritonitis. [PDF]

J Feline Med Surg
Objectives Current antiviral therapy for feline infectious peritonitis (FIP) has limited availability and can be cost-prohibitive. The nucleoside analogue EIDD-1931 is an effective inhibitor against FIP virus serotype I and II in vitro. Our objective was
Kennedy A, White J.
europepmc   +2 more sources

Clinical characteristics of SARS-CoV-2 infection in patients with chronic hepatitis B during interferon antiviral therapy. [PDF]

Biosaf Health
To investigate the clinical characteristics of coronavirus disease 2019 (COVID-19) infection in patients with chronic hepatitis B (CHB) during interferon antiviral therapy and to explore the correlation between interferon use and COVID-19 infection and ...
Wang S, Zhang Z, Li X, Deng W, Zhang Y, Cao W, Wei X, Gao Z, Yao L, Wang S, Xie Y, Li M.   +11 more
europepmc   +2 more sources

Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma. [PDF]

Nat Commun, 2019
Protein kinase A (PKA) is typically activated by cAMP. Here, Bachmaier et al. show that PKA of Trypanosoma is activated by nucleoside-related ligands, explain the ligand selectivity swap by a co-crystal structure of trypanosome PKAR, and identify ...
Bachmaier S, Volpato Santos Y, Kramer S, Githure GB, Klöckner T, Pepperl J, Baums C, Schenk R, Schwede F, Genieser HG, Dupuy JW, Forné I, Imhof A, Basquin J, Lorentzen E, Boshart M.   +15 more
europepmc   +2 more sources

Caenorhabditis elegans as a model system for studying drug induced mitochondrial toxicity [PDF]

, 2015
Today HIV-1 infection is recognized as a chronic disease with obligatory lifelong treatment to keep viral titers below detectable levels. The continuous intake of antiretroviral drugs however, leads to severe and even life-threatening side effects ...
Brul, Stanley, de Boer, Richard, De Vos, Winnok, Manders, Erik MM, Smith, Ruben L, van der Spek, Hans   +5 more
core   +19 more sources

Effects of nucleoside analogue on patients with chronic hepatitis B-associated liver failure: meta-analysis. [PDF]

PLoS ONE, 2013
PURPOSE: The effectiveness of nucleoside analogue on patients with chronic hepatitis B-associated liver failure is still controversial. To address this issue, we did a review of the literatures and analyzed the data with emphasis on the survival and ...
Feng Xie, Long Yan, Jiongjiong Lu, Tao Zheng, Changying Shi, Jun Ying, Rongxi Shen, Jiamei Yang   +7 more
doaj   +1 more source