Results 41 to 50 of about 2,623 (158)

Purine Nucleoside Phosphorylase Inhibition Rebalances Purine Metabolism and Attenuates Organ Damage in Sickle Cell Mice

Journal of Cellular and Molecular Medicine, Volume 29, Issue 24, December 2025.
ABSTRACT Red blood cells (RBCs) contain the highest purine nucleoside phosphorylase (PNP) level per cell volume, yet the role of PNP in the pathogenesis of sickle cell disease (SCD) is incompletely understood, highlighting an important gap in our knowledge of the disease.
Adekunle Emmanuel Alagbe, Lynda Little‐Ihrig, Stephanie M. Mutchler, Edwin K. Jackson, Enrico M. Novelli, Stevan P. Tofovic   +5 more
wiley   +1 more source

Life without dUTPase [PDF]

, 2016
Fine-tuned regulation of the cellular nucleotide pools is indispensable for faithful replication of Deoxyribonucleic Acid (DNA). The genetic information is also safeguarded by DNA damage recognition and repair processes.
Altschul, Bjornberg, Bohr, Boshoff, Castillo-Acosta, Castillo-Acosta, Chen, Chen, Cole, Cone, Dengg, el-Hajj, Galperin, Golding, Goncalves, Helt, Hogrefe, Huffman, Huson, Jiricny, Kana, Kiljunen, Kunkel, Lindahl, Lu, Meier, Merenyi, Minton, Mir-Sanchis, Moroz, Muha, Nagy, Nelson, Novick, Peacock, Pecsi, Rona, Serrano-Heras, Serrano-Heras, Sire, Szabo, Takahashi, Uchiyama, Vertessy, Visnes, Wang, Wang, Wang, Weil   +48 more
core   +2 more sources

Metabolic Origin, Role and Fate of the Denaturant Guanidine

Microbial Biotechnology, Volume 18, Issue 11, November 2025.
The origin of metabolic guanidine is largely a mystery. We suggest it is created when guanine‐containing nucleotides are oxidised by molecular oxygen instead of being broken down into urea as purines normally would. Guanidine may act as a signal to help cells control the level of reactive oxygen species.
Antoine Danchin, Victor de Lorenzo, Pablo Iván Nikel, Conghui You   +3 more
wiley   +1 more source

Reactive species and DNA damage in chronic inflammation: Reconciling chemical mechanisms and biological fates [PDF]

, 2010
Chronic inflammation has long been recognized as a risk factor for many human cancers. One mechanistic link between inflammation and cancer involves the generation of nitric oxide, superoxide and other reactive oxygen and nitrogen species by macrophages ...
Anant, Asahi, Asaka, Badawi, Badouard, Balkwill, Barnes, Bartsch, Blair, Blair, Bouvard, Bredt, Broedbaek, Budiawan, Buettner, Cary, Chaudhuri, Chen, Chen, Cho, Cho, Chung, Chung, Chung, Chung, Colotta, Cooke, Cooke, Coussens, David, Dechakhamphu, Dechakhamphu, Dedon, Dedon, Dedon, Dong, Dong, Douki, Douki, Ebert, EESCoOD, Eiserich, Evans, Farrell, Flores-Santana, Friedman, Glaser, Godschalk, Groopman, Gross, Hailer, Halliwell, Harris, Hazen, Hazen, Henderson, Herszenyi, Hillestrom, Hirst, Hoberg, Holmgren, Hoopengardner, Huang, Hughes, Hussain, IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, Itzkowitz, Jeong, Keegan, Knutson, Knutson, Knutson, Kozekov, Lancaster, Lee, Lewis, Lim, Lima, MacMicking, Mancardi, Mao, Marnett, Marnett, Marnett, Marnett, Masuda, Maynard, Meerang, Minko, Miwa, Moncada, Mossman, Mossman, Mostafa, Nair, Nair, Nair, Nathan, Nathan, Nelson, Ohshima, Ohshima, Olliver, Otteneder, Pan, Pang, Pawlowicz, Paz-Elizur, Pham, Plastaras, Plastaras, Pouget, Reuter, Reynaud, Riggins, Riggins, Sanchez, Sawa, Schnetz-Boutaud, Schnetz-Boutaud, Schottenfeld, Seril, Shafirovich, Shapiro, Shapiro, Shen, Shigenaga, Sripa, Steenken, Stone, Stuehr, Suzuki, Suzuki, Tan, Thomas, Thun, Turney, Uppu, van der Vliet, Virchow, Visconti, Visnes, Wang, Whitcomb, Wink, Wink, Winter, Wu, Yanagawa, Yonekura, Zhang, Zhang, Zhou   +152 more
core   +1 more source

Cardiomyocyte‐Specific Deletion of Sirtuin 5 Accelerates the Development of Heart Failure Upon Dysregulating Purine Metabolism

Acta Physiologica, Volume 241, Issue 11, November 2025.
ABSTRACT Aim Sirtuin 5 (SIRT5), a mitochondrial NAD+‐dependent deacylase, regulates fundamental cellular pathways, including energy substrate metabolism. The current study is designed to better elucidate the role of SIRT5 in the development of heart failure (HF). Methods Mice with cardiomyocyte‐specific deletion (cSirt5−/−) or overexpression (cSirt5‐Tg)
Nikole J. Byrne, Christoph Koentges, Katharina Pfeil, Julia C. Lueg, Sayan Bakshi, Aleksandre Tarkhnishvili, Ivan Vosko, Johannes Gollmer, Laura C. Birkle, Thomas Rathner, Stephan Birkle, Sibai Tang, Clara Rau, Michael M. Hoffmann, Katja E. Odening, Stephen Barnes, Landon Shay Wilson, Senka Ljubojevic‐Holzer, Markus Wallner, Dirk von Lewinski, Peter Rainer, Simon Sedej, Harald Sourij, Christoph Bode, Adam R. Wende, Andreas Zirlik, Heiko Bugger   +26 more
wiley   +1 more source

Inhibition of Escherichia coli cytidine deaminase by a phosphapyrimidine nucleoside.

Journal of Biological Chemistry, 1984
The nature of the interaction between Escherichia coli cytidine deaminase and the phosphapyrimidine nucleoside 1 has been studied kinetically and spectrophotometrically. Compound 1 was designed as a transition-state analog, and is a potent, slow-binding inhibitor of cytidine deaminase (Ashley, G. W., and Bartlett, P. A. (1982) Biochem. Biophys.
G W, Ashley, P A, Bartlett
openaire   +2 more sources

Reactivity of Damaged Pyrimidines: DNA Cleavage via Hemiaminal Formation at the C4 Positions of the Saturated Thymine of Spore Photoproduct and Dihydrouridine [PDF]

, 2014
Described here are mechanistic details of the chemical reactivities of two modified/saturated pyrimidine residues that represent naturally occurring forms of DNA damage: 5-thyminyl-5,6-dihydrothymine, commonly referred to as the “spore photoproduct” (
Dria, Karl J., Jian, Yajun, Li, Lei, Lin, Gengjie, Long, Eric C.   +4 more
core   +3 more sources

Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy

Advanced Science, Volume 12, Issue 40, October 27, 2025.
Metabolic rewiring in cancer is mapped across glucose, amino acid, lipid, nucleotide, and mitochondrial pathways, with emphasis on immune regulation. The review integrates mechanisms linking these pathways to tumor progression and therapy resistance, and profiles nanomaterial platforms that both deliver therapeutics and actively reprogram ...
Xiaosu Zhou, Ruibing Deng, Zunde Liao, Xiaoyu Huang, Junting Huang, Hanlou Yang, Kam W. Leong, Yiling Zhong   +7 more
wiley   +1 more source

The metagenomic telescope. [PDF]

, 2014
Next generation sequencing technologies led to the discovery of numerous new microbe species in diverse environmental samples. Some of the new species contain genes never encountered before.
G. Vértessy, Beáta, Grolmusz, Vince, Nagy, Kinga, Scheer, Ildikó, Szalkai, Balázs   +4 more
core   +3 more sources

The Role of the Intestinal Microbiome in the Pathogenesis and Treatment of Hyperuricemia: A Review

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
This review summarizes the characteristics, prevalence, and treatment strategies of hyperuricemia, and subsequently examines its pathogenic mechanisms together with the potential roles and regulatory pathways of the gut microbiota in its alleviation.
Junyu Yang, Jiali Chen, Zhenmin Liu, Yezhi Qu, Xiqing Yue, Bo Yuan, Mohan Li   +6 more
wiley   +1 more source