Results 41 to 50 of about 2,632 (160)

Genetic variability in adenosine deaminase-like contributes to variation in alcohol preference in mice. [PDF]

, 2017
BACKGROUND: A substantial part of the risk for alcohol use disorder (AUD) is determined by genetic factors. We previously used chromosome substitution (CSS) mice, to identify a QTL for alcohol preference on mouse chromosome 2.
Bailey, A, Lesscher, HMB, Vanderschuren, LJMJ   +2 more
core   +1 more source

140 Reversing the Epidemic of HIV-1C in Southern Africa with Treatment as Prevention [PDF]

, 2014
The epidemic of HIV-1C in southern Africa is characterized by a sustained prevalence that is substantially higher than for other epidemics of HIV/AIDS. Perhaps the best correlate of transmission is high viral load (HVL), which we target to prevent spread
Essex, M.
core   +1 more source

Cordyceps sinensis (CS) Alleviates Chronic Obstructive Pulmonary Disease Symptoms (COPD) by Targeting Inflammation, Apoptosis, and Oxidative Stress Through Ingredient–Gene–Disease Interaction

Immunity, Inflammation and Disease, Volume 13, Issue 12, December 2025.
Our findings indicate that Cordyceps Sinensis (CS) alleviates COPD symptoms by inhibiting inflammation and oxidative stress, with key biomarkers such as interleukins (ILs), tumor necrosis factor (TNF), and reactive oxygen species (ROS) identified. Activating autophagy serves as a protective mechanism against COPD development induced by oxidative stress.
Zirui Zang, Yuhan Kong, Qi Kong
wiley   +1 more source

Reactive species and DNA damage in chronic inflammation: Reconciling chemical mechanisms and biological fates [PDF]

, 2010
Chronic inflammation has long been recognized as a risk factor for many human cancers. One mechanistic link between inflammation and cancer involves the generation of nitric oxide, superoxide and other reactive oxygen and nitrogen species by macrophages ...
Anant, Asahi, Asaka, Badawi, Badouard, Balkwill, Barnes, Bartsch, Blair, Blair, Bouvard, Bredt, Broedbaek, Budiawan, Buettner, Cary, Chaudhuri, Chen, Chen, Cho, Cho, Chung, Chung, Chung, Chung, Colotta, Cooke, Cooke, Coussens, David, Dechakhamphu, Dechakhamphu, Dedon, Dedon, Dedon, Dong, Dong, Douki, Douki, Ebert, EESCoOD, Eiserich, Evans, Farrell, Flores-Santana, Friedman, Glaser, Godschalk, Groopman, Gross, Hailer, Halliwell, Harris, Hazen, Hazen, Henderson, Herszenyi, Hillestrom, Hirst, Hoberg, Holmgren, Hoopengardner, Huang, Hughes, Hussain, IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, Itzkowitz, Jeong, Keegan, Knutson, Knutson, Knutson, Kozekov, Lancaster, Lee, Lewis, Lim, Lima, MacMicking, Mancardi, Mao, Marnett, Marnett, Marnett, Marnett, Masuda, Maynard, Meerang, Minko, Miwa, Moncada, Mossman, Mossman, Mostafa, Nair, Nair, Nair, Nathan, Nathan, Nelson, Ohshima, Ohshima, Olliver, Otteneder, Pan, Pang, Pawlowicz, Paz-Elizur, Pham, Plastaras, Plastaras, Pouget, Reuter, Reynaud, Riggins, Riggins, Sanchez, Sawa, Schnetz-Boutaud, Schnetz-Boutaud, Schottenfeld, Seril, Shafirovich, Shapiro, Shapiro, Shen, Shigenaga, Sripa, Steenken, Stone, Stuehr, Suzuki, Suzuki, Tan, Thomas, Thun, Turney, Uppu, van der Vliet, Virchow, Visconti, Visnes, Wang, Whitcomb, Wink, Wink, Winter, Wu, Yanagawa, Yonekura, Zhang, Zhang, Zhou   +152 more
core   +1 more source

Genomic and Metabolic Characterization of a Potentially Novel Paenibacillus Species Isolated as a Laboratory Contaminant Growing on Medium Supporting Cotton Tissue Culture

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
This study explores the genomic and metabolic characterization of a potentially novel Paenibacillus species isolated from cotton plant tissues. Phylogenetic analysis based on multi‐locus sequence data from six conserved genes reveals that Paenibacillus sp. TAB_01 forms a distinct lineage among 19 Paenibacillus species. Paenibacillus sp.
Ilksen Topcu, Shravan Sharma Parunandi, Tristan Andrew Gregory, LeAnne M. Campbell, Keerti Rathore, Sanjay Antony‐Babu   +5 more
wiley   +1 more source

Adenosine Deaminating/ Hydrolyzing Enzymes from Alaska pea seeds (Pisum sativum) [PDF]

, 2017
Nucleoside deaminases and nucleoside hydrolases are essential within the purine salvage pathway to recycle purine bases to promote cellular functions such as DNA synthesis, cytokinin metabolism, and more.
Thicklin, Lendsey Breanna
core   +4 more sources

Life without dUTPase [PDF]

, 2016
Fine-tuned regulation of the cellular nucleotide pools is indispensable for faithful replication of Deoxyribonucleic Acid (DNA). The genetic information is also safeguarded by DNA damage recognition and repair processes.
Altschul, Bjornberg, Bohr, Boshoff, Castillo-Acosta, Castillo-Acosta, Chen, Chen, Cole, Cone, Dengg, el-Hajj, Galperin, Golding, Goncalves, Helt, Hogrefe, Huffman, Huson, Jiricny, Kana, Kiljunen, Kunkel, Lindahl, Lu, Meier, Merenyi, Minton, Mir-Sanchis, Moroz, Muha, Nagy, Nelson, Novick, Peacock, Pecsi, Rona, Serrano-Heras, Serrano-Heras, Sire, Szabo, Takahashi, Uchiyama, Vertessy, Visnes, Wang, Wang, Wang, Weil   +48 more
core   +2 more sources

Targeting Metabolic Reprogramming in Tumor: From Mechanisms to Precision Immunotherapies

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Cancer metabolic reprogramming is a key hallmark of tumorigenesis and antitumor immunity. It boosts tumor progression by enhancing cancer cell fitness in hostile microenvironments and facilitates immune evasion by evading natural and therapy‐driven antitumor immune responses.
Tong Zhang, Ping Gao, Linchong Sun
wiley   +1 more source

Inhibition of Escherichia coli cytidine deaminase by a phosphapyrimidine nucleoside.

Journal of Biological Chemistry, 1984
The nature of the interaction between Escherichia coli cytidine deaminase and the phosphapyrimidine nucleoside 1 has been studied kinetically and spectrophotometrically. Compound 1 was designed as a transition-state analog, and is a potent, slow-binding inhibitor of cytidine deaminase (Ashley, G. W., and Bartlett, P. A. (1982) Biochem. Biophys.
G W, Ashley, P A, Bartlett
openaire   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source