Results 81 to 90 of about 1,553 (134)

Diazepinone Nucleosides as Inhibitors of Cytidine Deaminase.

Nucleosides and Nucleotides, 1996
Abstract The synthesis of 2′-deoxy and 2′,3′-dideoxy derivatives of 1-s-D-ribofuranosyl-1,3,4,7-tetrahydro-2H-1,3-diazepin-2-one (2) was undertaken in order to find new cytidine deaminase (CDA) inhibitors and potential adjuvants in anticancer chemotherapy.
G. Cristalli, R. Volpini, S. Vittori, CAMAIONI, Emidio, G. Rafaiani, S. Potenza, A. Vita   +6 more
openaire   +3 more sources

Nucleoside deaminase and adenosine deaminase activities in regenerating mouse liver

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971
Abstract The specific activities of nucleoside deaminase (cytidine aminohydrolase, EC 3.5.4.5) and adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) were determined in extracts of mouse liver following 70 % hepatectomy. There was an increase in the levels of these enzymes which preceded the onset of DNA synthesis by many hours. Enzyme levels
I K, Rothman, R, Silber, K M, Klein, F F, Becker   +3 more
openaire   +2 more sources

Adenosine Deaminase in Nucleoside Synthesis

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Mukta Gupta, Vasu Nair
openaire   +1 more source

Adenosine Deaminase in Nucleoside Synthesis. A Review

Collection of Czechoslovak Chemical Communications, 2006
Adenosine deaminase (ADA) is an enzyme in the purine salvage pathway that catalyzes the deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. This deamination is an important factor in limiting the usefulness of adenosine analogues in chemotherapy.
Mukta Gupta, Vasu Nair
openaire   +1 more source

Erythrocyte adenosine deaminase and purine nucleoside phosphorylase activity in gout

Clinica Chimica Acta, 1975
1. Erythrocyte adenosine deaminase (EC 3.5.4.4) and purine nucleoside (inosine) phosphorylase (EC 2.4.1.1) were measured in 33 healthy controls and 43 primary gouty subjects. Adenosine deaminase activity in controls and gouty subjects was 0.373 plus or minus 0.108 and 0.457 plus or minus 0.140 A unit per 5-10-3 ml packed red cells per h, respectively.
T, Nishizawa, Y, Nishida, I, Akaoka, T, Yoshimura   +3 more
openaire   +2 more sources

Structure-Based de novo design of non-nucleoside adenosine deaminase inhibitors

Bioorganic & Medicinal Chemistry Letters, 2003
We searched for non-nucleoside inhibitors of adenosine deaminase by rational structure-based de novo design and succeeded in the discovery of 1-(1-hydroxy-4-phenyl-2-butyl)imidazole-4-carboxamide (FR221647: K(i)=5.9 microM to human ADA) as a novel inhibitor with moderate activity and good pharmacokinetics compared with the known inhibitors pentostatin ...
Tadashi, Terasaka, Isao, Nakanishi, Katsuya, Nakamura, Yoshiteru, Eikyu, Takayoshi, Kinoshita, Nobuya, Nishio, Akihiro, Sato, Masako, Kuno, Nobuo, Seki, Kazuo, Sakane   +9 more
openaire   +3 more sources

Therapy in adenosine deaminase and purine nucleoside phosphorylase deficient patients

Clinical Biochemistry, 1983
The discovery of the causal association of adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) deficiency with some forms of primary immunodeficiency disease had led to new approaches to therapy, such as enzyme replacement. In ADA deficiency, bone marrow transplantation remains the primary method of choice.
B J, Zegers, J W, Stoop
openaire   +2 more sources

A new screening method for adenosine deaminase and nucleoside phosphorylase

Journal of Immunological Methods, 1976
An improved screening test for both adenosine deaminase and nucleoside phosphorylase is described.
P J, Blake, J F, Greally
openaire   +2 more sources

Anti-inflammatory activity of non-nucleoside adenosine deaminase inhibitor FR234938

European Journal of Pharmacology, 2006
Adenosine has anti-inflammatory activity. Adenosine deaminase (EC 3.5.4.4) metabolizes extracellular adenosine, resulting in an exacerbation of inflammation. Consequently, it was hypothesized that adenosine deaminase inhibitors produce anti-inflammatory activity by increasing extracellular adenosine concentration.
Masako, Kuno, Nobuo, Seki, Susumu, Tsujimoto, Isao, Nakanishi, Takayoshi, Kinoshita, Katsuya, Nakamura, Tadashi, Terasaka, Nobuya, Nishio, Akihiro, Sato, Takashi, Fujii   +9 more
openaire   +2 more sources

Non-nucleoside adenosine deaminase inhibitors: 2000 – 2004

Expert Opinion on Therapeutic Patents, 2005
Adenosine deaminase (ADA) is a crucial enzyme in purine metabolism that irreversibly deaminates adenosine to form inosine. ADA is ubiquitous in human tissues and plays a crucial role in immune system development. ADA inhibitors may be useful for the treatment of ischaemic injury, hypertension, lymphomas and leukaemia.
openaire   +1 more source