Results 21 to 30 of about 115,586 (202)
Structural analyses reveal two distinct families of nucleoside phosphorylases. [PDF]
Biochem J, 2002 Pugmire MJ, Ealick SE.
europepmc +2 more sources
Diversification of 4′-Methylated Nucleosides by Nucleoside Phosphorylases [PDF]
ACS Catalysis, 2021 The growing demand for 4'-modified nucleoside analogs in medicinal and biological chemistry is contrasted by the challenging synthetic access to these molecules and the lack of efficient diversification strategies. Herein, we report the development of a biocatalytic diversification approach based on nucleoside phosphorylases, which allows the ...
Felix Kaspar +11 more
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Diversification of 4ʹ-Methylated Nucleosides by Nucleoside Phosphorylases
ACS Catalysis, 2021 The growing demand for 4'-modified nucleoside analogs in medicinal and biological chemistry is contrasted by the challenging synthetic access to these molecules and the lack of efficient diversification strategies.
F. Kaspar +11 more
semanticscholar +1 more source
Purine nucleoside phosphorylase [PDF]
Biomeditsinskaya Khimiya, 2013 Purine nucleoside phosphorylase (PNP) is one of the most important enzymes of the purine metabolism, wich promotes the recycling of purine bases. Nowadays is the actual to search for effective inhibitors of this enzyme which is necessary for creation T-cell immunodeficient status of the organism in the organs and tissues transplantation, and ...
L G, Pogosian, Zh I, Akopian
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SOME RECENT FINDINGS IN THE BIOTECHNOLOGY OF BIOLOGICALLY IMPORTANT NUCLEOSIDES [PDF]
Biotechnologia Acta, 2013 Some recent findings in the biotechnology of biologically important nucleosides will be discussed, viz., (i) a new strategy of the cascade one-pot transformation of D-pentoses into nucleosides based on the extension and deepening of the knowledge of the ...
A. Mikhailopulo, A. I. Miroshnikov
doaj +1 more source
Thermodynamic reaction control of nucleoside phosphorolysis [PDF]
, 2020 Nucleoside analogs represent a class of important drugs for cancer and antiviral treatments. Nucleoside phosphorylases (NPases) catalyze the phosphorolysis of nucleosides and are widely employed for the synthesis of pentose‐1‐phosphates and nucleoside ...
Giessmann, Robert T. +4 more
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Bioresource Technology, 2020 In this work, a mono- and a bi-enzymatic analytical immobilized enzyme reactors (IMERs) were developed as prototypes for biosynthetic purposes and their performances in the in-flow synthesis of nucleoside analogues of pharmaceutical interest were ...
F. Rinaldi +11 more
semanticscholar +1 more source
PNP (Purine Nucleoside Phosphorylase) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018 The purine nucleoside phosphorylase gene (PNP) encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. PNP is ubiquitously expressed in mammalian cells and tissues. PNP mutations cause nucleoside phosphorylase deficiency which result in defective T cell mediated immunity but can also affect B cell immunity and antibody ...
Gurbanov, Rafig, Tunçer, Sinem
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A UV/Vis Spectroscopy-Based Assay for Monitoring of Transformations Between Nucleosides and Nucleobases [PDF]
, 2019 Efficient reaction monitoring is crucial for data acquisition in kinetic and mechanistic studies. However, for conversions of nucleosides to their corresponding nucleobases, as observed in enzymatically catalyzed nucleoside phosphorylation reactions, the
Giessmann, Robert T. +5 more
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Innovative Agents for Actinic Keratosis and Nanocarriers Enhancing Skin Penetration [PDF]
, 2010 Actinic keratosis and cutaneous squamous cell carcinoma are of increasing importance with aging and increased ultraviolet light exposure in Western societies. Efficient and well-tolerated therapy is still a matter of concern.
Höltje, H.-D. +3 more
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