Ischemic nucleotide breakdown increases during cardiac development due to drop in adenosine anabolism/catabolism ratio [PDF]
, 1990 Our earlier work on reperfusion showed that adult rat hearts released almost twice as much purine nucleosides and oxypurines as newborn hearts did [Am J Physiol 254 (1988) H1091].
Huizer, T. (Tom) +3 more
core +2 more sources
The evolution of an allosteric site in phosphorylase [PDF]
, 1996 Background: Glycogen phosphorylases consist of a conserved catalytic core onto which different regulatory sites are added. By comparing the structures of isozymes, we hope to understand the structural principles of allosteric regulation in this family of
Rath +32 more
core +1 more source
Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy [PDF]
, 2017 Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Ali, Juma A.M. +7 more
core +2 more sources
Pinpointing dynamic coupling in enzymes for efficient drug design [PDF]
, 2016 Enzymes are proteins that catalyze almost every chemical reaction in living systems, achieving rate enhancements of up to 21 orders of magnitude relative to the uncatalyzed reactions.
Glasstone S, Haldane JBS, Polanyi M
core +1 more source
An improved technique for isolated perfusion of rat livers and an evaluation of perfusates [PDF]
, 1992 We have modified the apparatus for isolated rat liver perfusion (IPRL) in order to be able to perform two perfusions simultaneously. In addition, we studied the quality and stability of livers by comparison of five different perfusates: Blood (Group A ...
Liu, T +7 more
core +1 more source
Evolutionary history of Leishmania killicki (synonymous Leishmania tropica) and taxonomic implications [PDF]
, 2015 Background: Leishmania (L.) killicki is responsible for the chronic cutaneous leishmaniasis. The taxonomic status of this parasite is still not well defined. It was suggested on one hand to include this taxon within L.
Babba, Hamouda +11 more
core +3 more sources
A novel thymidine phosphorylase to synthesize (halogenated) anticancer and antiviral nucleoside drugs in continuous flow [PDF]
, 2022 Four pharmaceutically relevant nucleoside analogues (5-fluoro-2’-deoxyuridine, 5-chloro-2’-deoxyuridine, 5-bromo-2’-deoxyuridine, and 5-iodo-2’-deoxyuridine) have been synthesized by using a novel thymidine phosphorylase from H.
Benitez-Mateos, Ana I +3 more
core +1 more source
Antiviral screening identifies adenosine analogs targeting the endogenous dsRNA Leishmania RNA virus 1 (LRV1) pathogenicity factor. [PDF]
, 2017 The endogenous double-stranded RNA (dsRNA) virus Leishmaniavirus (LRV1) has been implicated as a pathogenicity factor for leishmaniasis in rodent models and human disease, and associated with drug-treatment failures in Leishmania braziliensis and ...
Beverley, S.M. +5 more
core +1 more source
Arthritis &Rheumatology, Accepted Article.Background Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients don't respond. Low inosine‐triphosphate‐pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated ITPA role and the underlying mechanisms in vitro.
Sofia Sindici Forgiarini +19 more
wiley +1 more source
Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction
PROTEOMICS, EarlyView.ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella +6 more
wiley +1 more source