Results 51 to 60 of about 115,586 (202)

Anatomical Distribution of Nucleoside System in the Human Brain and Implications for Therapy [PDF]

, 2013
Nucleosides have a wide range of physiological and pathophysiological roles in the human brain as modulators of a variety of neural functions. For example, adenosine, inosine, guanosine, and uridine participate in the mechanisms underlying memory ...
Dobolyi, Árpád, Kovács, Zsolt
core   +1 more source

Collagen and microvascular alterations contribute to neuromuscular degeneration and disease progression in chronic intestinal pseudo‐obstruction

Journal of Internal Medicine, EarlyView.
Abstract Background Chronic intestinal pseudo‐obstruction (CIPO) is a severe gastrointestinal motility disorder that may be idiopathic or associated with systemic disease. In idiopathic cases, the pathophysiological mechanisms remain poorly defined. Although mutations in angiogenic factors have been reported in mitochondrial forms of CIPO, their role ...
Elisa Boschetti, Irene Neri, Leonardo Caporali, Elena Bonora, Carolina Malagelada, Claudio Fiorini, Danara Ormanbekova, Alessandro Berghella, Roberto D'Angelo, Rita Rinaldi, Cristiana Caliceti, Anna Costanzini, Mirella Falconi, Vincenzo Stanghellini, Stefano Ratti, Lucia Manzoli, Valerio Carelli, Roberto De Giorgio   +17 more
wiley   +1 more source

Mycoplasmas and cancer [PDF]

, 2014
The standard of care for patients suffering cancer often includes treatment with nucleoside analogues (NAs). NAs are internalized by cell-specific nucleobase/nucleoside transporters and, after enzymatic activation (often one or more phosphorylation steps)
Balzarini, Jan, Liekens, Sandra, Vande Voorde, Johan   +2 more
core  

Gut microbiota modulation of chemotherapy efficacy and toxicity [PDF]

, 2017
Evidence is growing that the gut microbiota modulates the host response to chemotherapeutic drugs, with three main clinical outcomes: facilitation of drug efficacy; abrogation and compromise of anticancer effects; and mediation of toxicity.
Alexander, James L., Kinross, James M., Marchesi, Julian Roberto, Nicholson, Jeremy K., Teare, Julian, Wilson, Ian D.   +5 more
core   +1 more source

A Simple Method for RNA‐Seq of Manually Isolated Chromatophores in Oryzias Fishes

Development, Growth &Differentiation, Volume 68, Issue 3, April 2026.
ABSTRACT RNA sequencing (RNA‐seq) has become an essential tool for analyzing gene expression and exploring cell type–specific transcriptomes. However, sample preparation and quality control remain challenging, as current approaches typically rely on dissecting tissues containing mixed cell populations or using flow cytometry to isolate fluorescently ...
Makoto Goda, Asuka Miyagi, Keisuke Sugiwaka, Masakatsu Watanabe, Manabu Bessho‐Uehara, Masahiko Hibi, Atsushi Toyoda, Rieko Tanaka, Kawilarang W. A. Masengi, Kazunori Yamahira, Satoshi Ansai, Hisashi Hashimoto   +11 more
wiley   +1 more source

Some inhibitors of purine nucleoside phosphorylase [PDF]

Biomeditsinskaya Khimiya, 2011
Purine nucleoside phosphorylase (PNP) catalyzes reversible phosphorolysis of purine deoxy- and ribonucleosides with formation (d)Rib-1-P and corresponding bases. PNP plays a leading role in the cell metabolism of nucleosides and nucleotides, as well as in maintaining the immune status of an organism.
L G, Pogosian, L S, Nersesova, M G, Gazariants, Z S, Mkrtchian, Zh I, Akopian   +4 more
openaire   +2 more sources

The cytokinesis regulator RacGAP1 is a Rac1‐specific GAP on membranes

Protein Science, Volume 35, Issue 3, March 2026.
Abstract Rho family small GTPases are essential for cytokinesis completion. RacGAP1, a dimeric multidomain protein with a lipid‐binding C1 domain and a GTPase‐activating protein (GAP) domain, is a major regulator in this process. However, despite many cellular and biochemical studies, whether RhoA or Rac1 is the actual substrate inactivated by RacGAP1 ...
Pavlina Dubois, Yann Ferrandez, Clara Rey, Cyril Pages, Agata Nawrotek, Jacqueline Cherfils   +5 more
wiley   +1 more source

Acclimation responses of Arabidopsis thaliana to sustained phosphite treatments [PDF]

, 2013
Phosphite () induces a range of physiological and developmental responses in plants by disturbing the homeostasis of the macronutrient phosphate. Because of its close structural resemblance to phosphate, phosphite impairs the sensing, membrane transport,
Berkowitz, O., Fenske, R., Finnegan, P.M., Hardy, G.E.S.J., Jost, R., Kollehn, D.O., Lambers, H., O'Brien, P.A.   +7 more
core   +2 more sources

Wernicke Encephalopathy Complicating a Distinctive POLG Phenotype With MNGIE‐Like Features

European Journal of Neurology, Volume 33, Issue 3, March 2026.
ABSTRACT Background Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an extremely rare autosomal recessive disease caused by variants in the thymidine phosphorylase gene (TYMP), primarily characterized by severe gastrointestinal and neurological symptoms.
Giuliana Capece, Luca Caumo, Sara Volta, Pietro Riguzzi, Elena Sogus, Angela Petrosino, Sara Vianello, Daniele Sabbatini, Leonardo Salviati, Renzo Manara, Carlo Viscomi, Gianni Sorarù, Luca Bello, Elena Pegoraro   +13 more
wiley   +1 more source

Family-specific scaling laws in bacterial genomes [PDF]

, 2017
Among several quantitative invariants found in evolutionary genomics, one of the most striking is the scaling of the overall abundance of proteins, or protein domains, sharing a specific functional annotation across genomes of given size.
de Lazzari, Eleonora, Grilli, Jacopo, Lagomarsino, Marco Cosentino, Maslov, Sergei   +3 more
core   +3 more sources