Results 91 to 100 of about 151,614 (341)
MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis
Advanced Science, EarlyView.This study uncovers a size‐dependent adhesion paradigm, demonstrating that the glycocalyx protein MUC15 suppresses pancreatic cancer progression by attenuating integrin activation, focal adhesion assembly, and YAP mechanotransduction. Integrating computational modeling and experimental validation, the work reveals a mechanical mechanism by which MUC15 ...
Simei Zhang +18 more
wiley +1 more source
RESEARCHES ON PYRIMIDINES. LXXXIV. THE TRANSFORMATION BY HYDROLYSIS OF SECONDARY PYRIMIDINE NUCLEOSIDES INTO IMIDAZOL COMBINATIONS. [PDF]
, 1917 Treat B. Johnson, Sidney E. Hadley
openalex +1 more source
Tumor Microenvironment‐Responsive Nanomedicines for Potentiating Cancer Immunotherapy
Advanced Science, EarlyView.Strategies for TME‐responsive Nanomaterials to Potentiate Cancer Immunotherapy. Abstract Immunotherapy has emerged as a transformative paradigm in oncology, yet its clinical efficacy remains constrained by the immunosuppressive tumor microenvironment and inadequate spatiotemporal control of existing modalities, resulting in suboptimal patient response ...
Qianqian Huang +7 more
wiley +1 more source
Selective prebiotic formation of RNA pyrimidine and DNA purine nucleosides
Nature, 2020 Jianfeng Xu +8 more
semanticscholar +1 more source
Study of intermolecular interactions of antiviral agent tilorone with RNA and nucleosides
Біофізичний вісник, 2018 Background: While antiviral and interferon-inducing agent tilorone is used as a reactant of a number of popular pharmacological preparations, the molecular mechanisms of its biological antiviral activity are under discussions among the specialists.
V. A. Pashynska +5 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Neuropathic pain management via repeated electroacupuncture. Abstract Background Existing remedial approaches for relieving neuropathic pain (NPP) are challenging and open the way for alternative therapeutic measures such as electroacupuncture (EA). The mechanism underlying the antinociceptive effects of repeated EA sessions, particularly concerning ...
Faisal Ayub Kiani +6 more
wiley +1 more source
Syntheses of 15N-labeled pre-queuosine nucleobase derivatives
Beilstein Journal of Organic Chemistry, 2014 Pre-queuosine or queuine (preQ1) is a guanine derivative that is involved in the biosynthetic pathway of the hypermodified tRNA nucleoside queuosine (Que). The core structure of preQ1 is represented by 7-(aminomethyl)-7-deazaguanine (preQ1 base).
Jasmin Levic, Ronald Micura
doaj +1 more source
Respiratory virus mRNA vaccines: mRNA Design, clinical studies, and future challenges
Animal Models and Experimental Medicine, EarlyView.Abstract Respiratory infectious diseases frequently erupt on a global scale, with RNA viruses, such as SARS‐CoV‐2, RSV, and influenza viruses, posing challenges to vaccine development due to their high mutation rates. Traditional vaccine development cycles are lengthy and struggle to keep pace with rapidly evolving viruses, whereas messenger RNA (mRNA)
Linlin Zheng, Han Feng
wiley +1 more source
Second generation silver(I)-mediated imidazole base pairs
Beilstein Journal of Organic Chemistry, 2014 The imidazole–Ag(I)–imidazole base pair is one of the best-investigated artificial metal-mediated base pairs. We show here that its stability can be further improved by formally replacing the imidazole moiety by a 2-methylimidazole or 4-methylimidazole ...
Susanne Hensel +3 more
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Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents
Molecules, 2019 Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis ...
Anastasia L. Khandazhinskaya +13 more
doaj +1 more source