Results 91 to 100 of about 36,245 (244)
International Journal of COPD, 2018 Xiao Sun,1 Zhonghua Dong,1 Nan Li,1 Xiuli Feng,1 Yan Liu,1 Ang Li,1 Xiaosong Zhu,1 Chunyan Li,1 Zhongxi Zhao1–3 1School of Pharmaceutical Sciences, Shandong University, Jinan, People’s Republic of China; 2Shandong Engineering and Technology ...
Sun X +8 more
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Nucleoside Triphosphate-Nucleoside Diphosphate Transphosphorylase (Nucleoside Diphosphokinase)
Journal of Biological Chemistry, 1973 Richard Palmieri +5 more
openaire +1 more source
Self‐Calibrating Ratiometric DNA Aptamer Probe for Quantitative ATP Imaging in Living Cells
Chemistry – A European Journal, EarlyView.We developed the RFA–ECHO probe, an internally calibrated ATP sensor that remains responsive across millimolar ATP levels. Its self‐correcting Cy5/ECHO ratio ensures accurate quantification independent of probe uptake. Compared with FRET‐based sensors, it yields a robust ratiometric shift, distinguishing high‐ATP cancer cells from normal ones, enabling
Yunsong Xu +5 more
wiley +1 more source
Nucleoside Triphosphate-Nucleoside Diphosphate Transphosphorylase (Nucleoside Diphosphokinase)
Journal of Biological Chemistry, 1964 Robert L. Ratliff +3 more
openaire +1 more source
Chemistry – A European Journal, EarlyView.A two‐step process was transferred from batch to flow mode for the synthesis of (R)‐2‐fluoro‐1‐phenylethanol as a benchmark, consisting of a decarboxylative fluorination in aqueous media, followed by an enantioselective biocatalytic reduction of the prochiral intermediate with RrADH immobilized on silica supraparticles.
Egzon Cermjani +7 more
wiley +1 more source
Mini‐Hairpin DNA: Extraordinarily Stable Structure and Its Applications
Chemistry – A European Journal, EarlyView.Mini‐hairpin DNA fragments containing GCGAAGC and GCGAAAGC form exceptionally stable hairpin‐like structures, with only two G−C pairs and one sheared G−A pair, remaining undenatured in 7 M urea and resisting nuclease digestion. These mini‐hairpin sequences frequently appear in replication and transcription origins, influence DNA sequencing fidelity ...
Michiko Kimoto, Ichiro Hirao
wiley +1 more source
Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents
Chemistry – A European Journal, EarlyView.This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley +1 more source
Cancer Nexus, EarlyView.ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han +5 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka +12 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Thiopurine methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) are key enzymes that catabolize thiopurines. Decreased or no‐function alleles in TPMT and NUDT15 are associated with reduced or no enzyme activity and predictive of pronounced adverse effects, including severe myelosuppression, that may occur among individuals treated with standard ...
Maud Maillard +18 more
wiley +1 more source