Results 81 to 90 of about 58,095 (298)
Synthesis and antiviral activities of 1,3-oxathiolanyl nucleosides with 5-hydroxymethyl substituent
, 2016 Novel 1,3-oxathiolanyl pyrimidine nucleosides with 5-hydroxymethyl substituent were synthesized starting from D-mannose and evaluated for antiviral activities against HIV-1, HSV type 1,2 and ...
정낙신
core +1 more source
Synthesis of novel xylofuranosyloxymethyl nucleosides
, 2014 The ability to selectively trap xylofuranosyloxy carbocation instead of the xylofuranosyl cation by activation of acetoxymethoxy leaving group at the anomeric centre is demonstrated for the synthesis of xylofuranosyloxymethyl nucleosides.
Mereyala, Hari Babu +2 more
core +1 more source
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Chronic rhinosinusitis (CRS) is frequently associated with polymicrobial biofilms involving Staphylococcus aureus and Pseudomonas aeruginosa. Interactions between these organisms are thought to influence disease severity, but the epithelial effects of exoproteins derived from patient‐matched cocultures remain poorly defined ...
Xiaohan Sun +6 more
wiley +1 more source
Functional Specialization of Respiratory and Olfactory Mucus Revealed by Proteomic Profiling
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Mucus overlies the nasal mucosa in the respiratory and olfactory regions, which perform distinct physiological functions. However, proteomic differences between respiratory mucosa (RM) and olfactory cleft (OC) mucus remain unclear.
Anna Kristina Hernandez +7 more
wiley +1 more source
Novel D- and L- Cyclohexenyl Nucleosides: Asymmetric synthesis and antiviral activity
, 2016 with the aim to expand the repertoire of bioactive cyclohexenyl nucleosides, we have herein explored the synthesis and the antiviral potential of novel cyclohexenyl nucleosides 4 and ent-4, lacking the OH group at C5' position and therefore being ...
De Fenza, Maria. +7 more
core
Synthesis and anti-HCV activity of 2′-β-hydroxymethylated nucleosides
, 2018 Synthesis of 2′-β-hydroxymethyl nucleosides 3-6 was accomplished, using stereoselective hydroxymethylation as a key step. Adenine nucleoside 3 showed potent anti-HCV activity, implying that 2′-β- hydroxymethyl group has the appropriate electronic ...
이강만, 정낙신
core +1 more source
Palladium-Catalyzed Modification of Unprotected Nucleosides, Nucleotides, and Oligonucleotides
Molecules, 2015 Synthetic modification of nucleoside structures provides access to molecules of interest as pharmaceuticals, biochemical probes, and models to study diseases.
Kevin H. Shaughnessy
doaj +1 more source
Synthesis and biological evaluation of pyrimidine nucleosides fused with 3′,4′-tetrahydrofuran ring
, 2017 Pyrimidine nucleosides fused with 3′,4′-tetrahydrofuran ring were synthesized, starting from 1,2;5,6-di-O-isopropylidene-D-glucose and assayed for antiviral activities.
정낙신
core +1 more source
, 2018 Novel thioiso pyrimidine and purine nucleosides substituted with exocyclic methylene have been synthesized, starting from D-xylose. Cyclization of the dimesylate to the 4-thiosugar 6a proceeded in pure SN2 reaction in the presence of allylic functional ...
정낙신
core +1 more source
BiomoleculesMarine biofouling remains a major challenge for maritime industries, affecting submerged structures and vessels worldwide. The long-standing reliance on biocidal coatings, together with their documented environmental impacts, has led to increasingly ...
Sandra Pereira +6 more
doaj +1 more source