Results 91 to 100 of about 58,095 (298)

Synthesis of enantiopure pseudo-L-vinylcyclopropyl nucleosides bearing quaternary carbon as potential anti-herpesvirus agent

, 2017
Pseudo-l-vinylcyclopropyl adenine and guanine nucleosides 11 and 12 were designed and enantiopurely synthesized starting from (S)-epichlorohydrin using tandem alkylation, regioselective oxirane-ring opening, and chemoselective reduction as key steps ...
정낙신
core   +1 more source

Insights into the Mycosphere Fungal Community and Its Association with Nucleoside Accumulation in Ophiocordyceps sinensis

Journal of Fungi
Soil microbiomes are critical environmental factors influencing the occurrence and quality formation of Ophiocordyceps sinensis, a valuable medicinal fungus endemic to the Qinghai-Tibet Plateau. However, few studies have explored the relationship between
Jianshuang Zhang, Wen Zhang, Xiaodan Wu, Weidi Fu, Chaoyun Yang, Nana Long   +5 more
doaj   +1 more source

Study of intermolecular interactions of antiviral agent tilorone with RNA and nucleosides

Біофізичний вісник, 2018
Background: While antiviral and interferon-inducing agent tilorone is used as a reactant of a number of popular pharmacological preparations, the molecular mechanisms of its biological antiviral activity are under discussions among the specialists.
V. A. Pashynska, N. M. Zholobak, M. V. Kosevich, A. Gomory, P. K. Holubiev, A. I. Marynin   +5 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Multi-Target Neuroprotective Effects of Cordycepin and Adenosine from Cordyceps militaris Against Amyloid-β-Induced Neurotoxicity

Biomedicines
Background: Cordyceps militaris (C. militaris) is a medicinal mushroom recognized for its diverse pharmacological activities, largely attributed to its principal bioactive nucleosides, cordycepin and adenosine.
Ewen Se Thoe, Hao Dong Tan, Ayesha Fauzi, Sunita Chamyuang, Yin Quan Tang, Adeline Yoke Yin Chia   +5 more
doaj   +1 more source

Chemical modifications of natural nucleosides [PDF]

1997-03-31Some chemical modifications of natural nucleosides based on the general organic chemistry have been carried out. Base catalyzed elimination reactions at the 2', 3'-positions of purine and pyrimidine nucleosides proved to be regiospecific.
Minamoto, Katsumaro, 101799
core   +1 more source

Applications of nucleoside-based molecular probes for the in vivo assessment of tumour biochemistry using positron emission tomography (PET)

Brazilian Archives of Biology and Technology, 2007
Positron emission tomography (PET) is a non-invasive nuclear imaging technique. In PET, radiolabelled molecules decay by positron emission. The gamma rays resulting from positron annihilation are detected in coincidence and mapped to produce three ...
Leonard I. Wiebe
doaj   +1 more source

Dye Labelling of Nucleosides

, 2009
Dye-labelled nucleosides were obtained in 30–79% (average 45%) yields by treating N-(4-arylazobenzoyl)-1H-benzotriazoles 3a–b with appropriate nucleosides. Similarly, 3a–b afforded dye-labelled threoninol conjugates in 55–89% (average 67%) yields.
Katritzky, Alan R., Shanab, Karem, Khelashvili, Levan, Beagle, Judit K.   +3 more
core   +1 more source

Infrared Spectroscopy of RNA Nucleosides in a Wide Range of Temperatures

Life
The RNA world hypothesis suggests that early cellular ancestors relied solely on RNA molecules for both genetic information storage and cellular functions.
Susana Iglesias-Groth, Franco Cataldo, Martina Marin-Dobrincic   +2 more
doaj   +1 more source

Stannous Chloride: A Reagent for Removal of Dimethoxytrityl Group from 5'-Dimethoxytrityl Nucleosides [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1998
Detritylation of 5'-dimethoxytrityl nucleosides have been quantitatively achieved in minutes at room temperature under aprotic neutral conditions by using stannous chloride.
Ali Khalafi Nezhad, Reza Fareghi Alamdari   +1 more
doaj