Results 181 to 190 of about 193,772 (411)

Exploring the Discrepancies in the Biological Activities of Extracts From Guadua angustifolia Var. Bicolor Londoño Collected in Two Different Sites

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT Guadua angustifolia var. bicolor Lodoño is a Colombian bamboo species that has shown promising medicinal properties. This study aims to investigate the differences in the chemical composition and biological activity of extracts from two different populations of G. angustifolia var. bicolor, collected in Bauru and Tatuí, Brazil.
João Kazlauckas   +2 more
wiley   +1 more source

THE UTILIZATION OF PURINE NUCLEOSIDES FOR NUCLEIC ACID SYNTHESIS IN THE RAT

open access: hybrid, 1952
Bertram A. Lowy   +2 more
openalex   +1 more source

Synthesis and Metal‐Ion Binding Properties of Duplexes Containing Thymine Analogs with 1,2‐Diamine Groups

open access: yesChemBioChem, EarlyView.
The findings of thermal denaturation experiments indicate that duplexes containing thymine analogues with 1,2‐ethylenediamine side chains show stabilizing effects with five metal ions (e.g., Cu(II), Ni(II), Zn(II), Co(II), Cd(II)). The 1,2‐diamine side chain demonstrated to be useful as a new metal‐ion binding site.
Takahiro Atsugi   +3 more
wiley   +1 more source

SYNTHETIC NUCLEOSIDES

open access: hybrid, 1925
P.A. Levene, Harry Sobotka
openalex   +1 more source

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

open access: yesChemBioChem, EarlyView.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout   +1 more
wiley   +1 more source

Simultaneous Quantification of Nucleosides and Nucleotides from Biological Samples

open access: yesJournal of the American Society for Mass Spectrometry, 2019
Liqing He   +8 more
semanticscholar   +1 more source

Inhibition of Surfactin Biosynthesis in Bacillus Subtilis Using Cell‐Permeable Adenylation Domain Inhibitors

open access: yesChemBioChem, EarlyView.
L‐Leu‐AMS‐based adenylation domain inhibitors with the modification of 2′‐OH in the adenosine skeleton are synthesized. Coupled with affinity‐based protein profiling of nonribosomal peptide synthetases (NRPSs), their activities toward surfactin‐NRPSs in Bacillus subtilis are evaluated.
Fumihiro Ishikawa   +3 more
wiley   +1 more source

Proline Amide Catalyzes Formation of Toxic Crotonaldehyde from Acetaldehyde Under Physiologically Relevant Conditions

open access: yesChemBioChem, EarlyView.
Crotonaldehyde‐derived DNA lesions are reported in patients after ethanol exposure, which implies that crotonaldehyde is produced after ethanol ingestion. Here, we show that proline amide, which mimics N‐terminal proline residues on human proteins, can catalyze crotonaldehyde formation from the ethanol metabolite acetaldehyde under physiologically ...
Liam A. Thomas   +5 more
wiley   +1 more source

Selective [9‐15N] Guanosine for Nuclear Magnetic Resonance Studies of Large Ribonucleic Acids

open access: yesChemBioChem, EarlyView.
The small chemical shift anisotropy of nitrogen‐15 at the 9‐position in guanine (15N9‐G) leads to long T2 values and narrow NMR lines, particularly attractive to probe structure and dynamics of large (>200 nucleotide) ribonucleic acids (RNAs). RNAs regulate various cellular processes using malleable 3D structures, and understanding the factors that ...
Solomon K. Attionu   +5 more
wiley   +1 more source

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