Results 161 to 170 of about 130,320 (304)

Nucleoside [PDF]

, 2020
openaire   +1 more source

Novel Variants in PUS7 Associated With Intellectual Disability and Growth Retardation: Expanding the Clinical Spectrum in 13 Patients

Clinical Genetics, EarlyView.
Novel variants in PUS7 associated with intellectual disability and growth retardation: expanding the clinical spectrum in 13 patients. ABSTRACT Pseudouridylation is a frequent post‐transcriptional modification resulting in uridine isomerization in 5‐ribosyluracil, also called pseudouridine. This mechanism leads to RNA stability with an increase in base‐
Camille Bergès, Clément Sauvestre, Sophie Naudion, Catherine Vincent Delorme, Thomas Smol, Mélanie Rama, Stephanie Moortgat, Isabelle Maystadt, Rogier Kersseboom, Martina Wilke, Stefan Barakat, Yoann Vial, Laurence Perrin, Sandrine Passemard, Farooq Ahmad, Muhammad Umair, Tobias Haack, Mona Grimmel, Alma Kuechler, Anne Slavotinek, Patrick Devine, Ugur Hodoglugil, Faisal Zafar, Erum Afzal, Tracy Dudding‐Byth, Guillaume Jouret, Lucas Herissant, Stephanie Efthymiou, Henry Houlden, Marine Legendre, Vincent Michaud   +30 more
wiley   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Metabolism of Epigenetic Ribonucleosides Leads to Nucleolar Stress and Cytotoxicity. [PDF]

ACS Chem Biol
Sun X, Donlic A, Boyer JA, Press TE, Kim M, Reddy NK, Brangwynne CP, Rabinowitz JD, Kleiner RE.   +8 more
europepmc   +1 more source

Contrasting effects of different molecular crowding environments on base‐pair opening/closing dynamics of DNA triplex structures

The FEBS Journal, EarlyView.
Base‐pair opening and closing regulate nucleic‐acid structure, stability, and function, but how these motions behave under intracellular molecular crowding remains unclear. Using NMR, we quantified these dynamics in a DNA triplex under two crowder‐reconstituted environments that mimic cellular crowding.
Tomoki Sakamoto, Yudai Yamaoki, Takashi Nagata, Masato Katahira   +3 more
wiley   +1 more source

Editorial: Nucleosides, nucleotides and nucleic acids: chemistry and biology

Frontiers in Chemistry
Leandro Soter de Mariz e Miranda, Raoni Schroeder Borges Gonçalves, Jacques Uziel, Jacques Uziel, Satoshi Obika, Nadege Lubin-Germain, Nadege Lubin-Germain   +6 more
doaj   +1 more source

Fungal <i>Cordyceps</i> Nucleosides and Analogs as Potential Anti-Glioblastoma PD-L1 Inhibitors: An In Silico Multiparameter Optimization (MPO) Design. [PDF]

Int J Mol Sci
Muñoz-González F, Bello M, Correa-Basurto J, Bandala C.   +3 more
europepmc   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Stereoselective synthesis of 1'-α-cyano carbocyclic pyrimidine nucleoside analogs <i>via</i> a chelation-controlled 1'-α-hydroxymethylation strategy.

Org Biomol Chem
Biteau NG, Kasthuri M, Patel D, De R, Schinazi RF, Amblard F.   +5 more
europepmc   +1 more source

(N)-Methanocarba Adenosine Derivatives as Dual Modulators of P-Glycoprotein and ABCG2 Transporters. [PDF]

J Med Chem
Murakami M, Tosh DK, Salazar PB, Jacobson KA, Ambudkar SV.   +4 more
europepmc   +1 more source