Results 161 to 170 of about 58,095 (298)

Integrated Elementomics-Genomics-Metabolomics Analysis Reveals Plasma Biomarker Networks and Diagnostic Potential for Gastric Cancer. [PDF]

Metabolites
Li R, Li G, Chen S, Lv X, Wang D, Xiang J, Jiang Y, Tan D, Wu C.   +8 more
europepmc   +1 more source

Novel Methods to Access Bioactive Molecules [PDF]

This thesis is divided into two chapters detailing research on applying microwave methodology to access aminated nucleosides in significantly reduced time frames, and applying the Belluš-Claisen reaction to produce non-proteogenic dipeptides.
Walsh, Anthony
core  

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

Phosphorus Chemistry and the Origin of Life: From N-Phosphoryl Amino Acid to Protocell. [PDF]

Acc Chem Res
Ying J, Liu Y, Fu S, Gao X, Zhao Y.
europepmc   +1 more source

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

Journal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.
This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá, Ladislav Androvič, Marcela Filipová, Michal Pechar, Richard Laga   +4 more
wiley   +1 more source

Targeted analysis of purine derivatives in beer and fermented beverages using HPLC-QDA. [PDF]

Food Chem X
Sen R, Schubert C, Rani H, Lafontaine S.
europepmc   +1 more source

Derivatives of 2,6-Diazidopurine and 2,6-Bis-(1,2,3-Triazol-1-yl) Purine as Useful Intermediates in the Synthesis of Modified Purine Nucleosides

Novel 2,6-bis-(1,2,3-triazol-1-yl)purine, N6-substituted-2-(1,2,3-triazol-1-yl)adenine and 6-alkyl/arylthio-2-(1,2,3-triazol-1-yl)purine and 2-alkylthio-6-(1,2,3-triazol-1-yl)purine nucleosides were synthesized.
Bizdēna, Ērika, Novosjolova, Irina, Turks, Māris   +2 more
core  

Human Prostate Cell Lines: Derivation, Molecular Characteristics and Appropriate Use

The Prostate, EarlyView.
ABSTRACT Background Research on prostate cancer and benign prostatic hyperplasia depends on a small number of immortalized human cell lines established between 1977 and 2001, most of them from advanced metastatic disease. The cell lines differ from one another in androgen receptor status, prostate‐specific antigen secretion, p53 status, karyotype and ...
Hamza Abohamra, Keenau Mark Pearce
wiley   +1 more source

Long-term stability of RNA nucleoside standards for accurate LC-MS quantification. [PDF]

Nucleic Acids Res
Kerkhoff K, Wesseling H, Qi Y, Obersteiner S, Liu K, Berg M, Rusling L, Zipse H, Kaiser S.   +8 more
europepmc   +1 more source

Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus

Pest Management Science, EarlyView.
Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano, Carmen Scieuzo, Rosanna Salvia, Riccardo Moretti, Flora Cozzolino, Maria Monti, Heiko Vogel, Patrizia Falabella   +7 more
wiley   +1 more source