Results 181 to 190 of about 82,908 (301)

Doxecitine and Doxribtimine: First Approval. [PDF]

Paediatr Drugs
Blair HA.
europepmc   +1 more source

MYC Addiction as a Targetable Vulnerability in Nelarabine‐Resistant T‐Cell Acute Lymphoblastic Leukemia

Cancer Science, EarlyView.
MYC drives nelarabine resistance in T‐ALL via a hyperactive transcriptional program. Pharmacological degradation of BET proteins dismantles this addiction, restoring drug sensitivity and extending survival in vivo. ABSTRACT Acquired resistance represents a fundamental obstacle limiting the long‐term efficacy of cancer chemotherapy.
Jingjing Gao, Chunxu Lin, Suchang Chen, Qi Mo, Chu Bao, Huali Deng, Ziyin Chen, Weichao Hao, Luyong Zhang, Min Wei   +9 more
wiley   +1 more source

Pentose bisphosphate pathway can act in central metabolism for nucleoside-dependent growth of <i>Thermococcus kodakarensis</i> strains. [PDF]

Appl Environ Microbiol
Nishida T, Chen Y, Azuma T, Orita I, Fukui T.   +4 more
europepmc   +1 more source

Phenotypic screening of a focused nucleoside library [PDF]

, 2016
Hulpia, Fabian, Van Calenbergh, Serge
core  

Discovery of a Novel γ‐Glutamylcyclotransferase Inhibitor Plumbagin by Luminescence‐Based High‐Throughput Screening

Cancer Science, EarlyView.
A cell‐based high‐throughput screening system utilizing the luminescent probe LISA‐103 was developed to monitor γ‐glutamylcyclotransferase (GGCT) activity in cancer cells. Through this assay, plumbagin was identified as a novel GGCT inhibitor that induces cell cycle arrest and suppresses cancer cell growth. ABSTRACT γ‐Glutamylcyclotransferase (GGCT) is
Keiko Taniguchi, Yukie Nohara, Mano Horinaka, Kozue Nose, Masaya Mori, Hiromi Ii, Hiroko Kawakami, Kazuto Yano, Susumu Nakata, Taku Yoshiya, Toshiyuki Sakai   +10 more
wiley   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Editorial: Nucleosides, nucleotides and nucleic acids: chemistry and biology

Frontiers in Chemistry
Leandro Soter de Mariz e Miranda, Raoni Schroeder Borges Gonçalves, Jacques Uziel, Jacques Uziel, Satoshi Obika, Nadege Lubin-Germain, Nadege Lubin-Germain   +6 more
doaj   +1 more source

Space ionizing radiation triggers the formation of peptides and organophosphates on olivine surfaces. [PDF]

Nat Commun
Ding R, Qiu S, Guo X, Zhang M, Liu Y, Zou Z, Ying J, Zhang M, Zhang B, Zhao Y.   +9 more
europepmc   +1 more source

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

The FEBS Journal, EarlyView.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna, Christoff Odendaal, Madhulika Singh, Albert Gerding, Miriam Langelaar‐Makkinje, Marianne van der Zwaag, Asmara Drachman, Vladimíra Cetkovská, Gaby Liem Foeng Kioen, Anne‐Claire M. F. Martines, Nicolette C. A. Huijkman, Hein Schepers, Bart van de Sluis, Dirk‐Jan Reijngoud, Ody C. M. Sibon, Amy C. Harms, Thomas Hankemeier, Barbara M. Bakker   +17 more
wiley   +1 more source

Rapid access to the core of malayamycin A by intramolecular dipolar cycloaddition. [PDF]

Beilstein J Org Chem
Liu Y, Yang Y, Yang C, Huang SH, Jin J, Hong R.   +5 more
europepmc   +1 more source