Results 151 to 160 of about 130,320 (304)

One-Step and Universal Strategy for the Synthesis of Hypermodified Uracil Phosphoramidites acp³U and cmnm⁵U. [PDF]

Chemistry
Mejdr E, Heinickel L, Carell T, Mejdr I.
europepmc   +1 more source

Dealing With Conflicts in Medical Decisions: Epistemic Reasonable Disagreement Between Parents and Medical Staff

Bioethics, EarlyView.
ABSTRACT Many controversies in medical ethics, particularly those involving conflicts between parents and medical staff over decisions about child patients, are challenging to manage without causing significant polarization and communication issues. This is primarily because the parties involved—parents and physicians—operate at different epistemic ...
Chiara Innorta
wiley   +1 more source

A Twist in Electronic Relaxation of Pyrimidine Nucleosides and Nucleotides: Impact of C5 Methylation on Nonadiabatic Transition and Photohydration Damage. [PDF]

J Am Chem Soc
Ghosh S, Obara Y, Jaiswal VK, Taddei M, Nenov A, Conti I, Garavelli M, Suzuki T.   +7 more
europepmc   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Non-Volatile Bioactive Properties of Mushroom Extracts (<i>Agaricus bisporus</i> and <i>Pleurotus ostreatus</i>). [PDF]

Molecules
Nowak A, Piotrowska M, Przydacz K, Czyżowska A, Rajkowska K, Dybka-Stępień K, Koziróg A, Otlewska A, Budryn G, Kołczyk A.   +9 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Polarized effects of adenosine on blood–brain barrier integrity: Tightening from the luminal and opening from the abluminal side

British Journal of Pharmacology, EarlyView.
Background and Purpose Adenosine as a signalling molecule modifies blood–brain barrier (BBB) tightness in pathological conditions. Our aim was to investigate the direct and polarized effects of adenosine on the BBB using co‐culture and in vivo models. Experimental Approach The expression of adenosine receptors was measured by qRT‐PCR.
András Harazin, Gabriela Hurtado‐Alvarado, Lilla Barna, Arturo Contis‐Montes de Oca, Rocío Ruíz‐Manzano, Krisztián Laczi, András Kincses, Gergő Porkoláb, Gang Chen, Beatriz Gómez‐González, Mária A. Deli   +10 more
wiley   +1 more source

Targeting <i>Plasmodium falciparum</i> with purine antimetabolites as a therapeutic strategy. [PDF]

Front Microbiol
Tashie W, de Koning HP, Duah-Quashie NO, Quashie NB.   +3 more
europepmc   +1 more source

MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy

Cancer Science, EarlyView.
MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley   +1 more source

Comparative analysis of expression, immunogenicity, and safety profiles between linear and circular RNA vaccine platforms. [PDF]

Mol Ther Nucleic Acids
Lee SY, Lee J, Ahn JH, Lee SY, Choi EJ, Ha D, Oh A, Jo S, Yoon S, Lee S, Bae HJ, Lee NY, Youn H, Kang BC, Nam JH.   +14 more
europepmc   +1 more source