Results 131 to 140 of about 82,908 (301)
European Journal of Organic Chemistry, EarlyView.This electrochemical methodology allows the preparation of bridged tricyclic scaffolds through a rapid increase in the molecular complexity of simple and readily accessible starting materials. Alcohols proved to be the most efficient nucleophiles, as well as 6‐chloropurine. Plausibly, the process involves an anodic oxidative dearomatization to generate
Emanuele Cartamina +4 more
wiley +1 more source
1,2‐Diazetidines − Structure, Synthesis, and Functionalization
European Journal of Organic Chemistry, EarlyView.1,2‐Diazetidines are saturated four‐membered heterocycles featuring two adjacent nitrogen atoms. Despite recent advances in their synthesis and promising potential in medicinal chemistry, the chemistry of these cyclic hydrazines remains underexplored.
Stefan Roesner
wiley +1 more source
Influence of a fluorobenzene nucleobase analogue on the conformational flexibility of RNA studied by molecular dynamics simulations [PDF]
, 2006 Chemically modified bases are frequently used to stabilize nucleic acids, to study the driving forces for nucleic acid structure formation and to tune DNA and RNA hybridization conditions.
Engels, Joachim W. (Prof. Dr.) +1 more
core
Chemical Syntheses of 3′ and 5′ Phosphorylated Oligonucleotides: An Overview
European Journal of Organic Chemistry, EarlyView.This review provides an overview of the various chemical methods employed in the synthesis of oligonucleotides bearing a phosphate group at their 3′ or 5′ end. Notably, it presents modified phosphoramidites and supports developed for this purpose. Oligonucleotides (ON) with a phosphate monoester group at their 3′ or 5′ end have applications in many ...
Rémy Lartia
wiley +1 more source
THE ROLE OF NUCLEOTIDE SUBSTANSES AND NO-SYNTHASE IN THE IMMUNE PROTECTION OF THE ORGANISM
Разработка и регистрация лекарственных средств, 2019 The present article describes the biochemical mechanisms and the possibility of nucleotides and nucleosides substances naturally produced (i.e. Saccharomyces cerevisiae and others) medicine application in field of correction of pathologically altered ...
V. S. Orlova +3 more
doaj
Induction of chromosome shattering and micronuclei by ultraviolet light and caffeine [PDF]
, 1980 Cremer, Christoph +2 more
core +1 more source
Health Economics, EarlyView.ABSTRACT Syphilis, a sexually transmitted infection that can lead to serious health complications, was almost eliminated in the United States by 2000. But since then, its incidence began to increase, recently reaching a 60‐year peak. We suggest that the introduction of the highly active antiretroviral therapy (HAART) drug regimen, which transformed HIV
David Beheshti +2 more
wiley +1 more source
, 2014 Citation: 'nucleosides' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.N04253 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source
Ibrain, Volume 11, Issue 1, Page 84-97, Spring 2025.This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou +6 more
wiley +1 more source