Results 131 to 140 of about 58,095 (298)
Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta
Clinical Pharmacology &Therapeutics, EarlyView.Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung +12 more
wiley +1 more source
Nucleoside Triphosphate-Nucleoside Diphosphate Transphosphorylase (Nucleoside Diphosphokinase)
Journal of Biological Chemistry, 1973 Richard Palmieri +5 more
openaire +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Antiretroviral pre‐exposure prophylaxis (PrEP) is less effective in women than expected, partly because drug exposure within the female genital tract is variable and may be influenced by the vaginal microbiome. We developed an integrated pharmacometrics and machine learning framework to evaluate associations between vaginal microbiome composition and ...
Diqin Yan +6 more
wiley +1 more source
Nucleoside Triphosphate-Nucleoside Diphosphate Transphosphorylase (Nucleoside Diphosphokinase)
Journal of Biological Chemistry, 1964 Robert L. Ratliff +3 more
openaire +1 more source
Jaw‐specific stem cell dynamics are associated with distinct enamel architecture in mouse incisors
Developmental Dynamics, EarlyView.Abstract Background The continuously growing mouse incisor serves as a model for stem cell‐driven tooth renewal. Although mice possess maxillary and mandibular incisors, most studies have focused on the mandible. Potential differences in structure and renewal between these serially homologous organs remain insufficiently characterized.
Elias Shahin +4 more
wiley +1 more source
Developmental Dynamics, EarlyView.Abstract Background Transcription factors of the MIT/TFE family—mitfa, mitfb, and tfec—play essential roles in specifying pigment cells derived from neural crest cells in vertebrates. In teleosts, which possess multiple pigment cell types, these factors exhibit partially redundant but largely distinct functions across different pigment lineages.
James Lister +13 more
wiley +1 more source
Corrigendum to ‘‘Application of 2,6-diazidopurine derivatives in the synthesis of thiopurine nucleosides’’ [Tetrahedron Lett.
Bizdēna, Ērika +2 more
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Epilepsia Open, EarlyView.Abstract Objective Cannabidiol (CBD) has demonstrated promising effectiveness and tolerability as adjunctive treatment in patients with severe childhood epilepsies. This study investigated the effectiveness and tolerability of CBD in adults with a history of Dravet syndrome (DS), Lennox–Gastaut syndrome (LGS), or tuberous sclerosis complex (TSC ...
Sara Sánchez‐Gamino +7 more
wiley +1 more source
Vaginal host–microbe signatures linked to placental outcomes in mares
Equine Veterinary Journal, EarlyView.Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule +7 more
wiley +1 more source
Exploration, EarlyView.This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi +5 more
wiley +1 more source