Results 121 to 130 of about 58,095 (298)
BMEMat, EarlyView.This review systematically summarizes the major molecular mechanisms governing TAM polarization and their coordinated interactions. It further highlights recent advances in nanoagonist‐based strategies that intervene in these pathways to reprogram TAMs, critically discussing their therapeutic potential, current limitations, and translational prospects.
Siqi Fang +7 more
wiley +1 more source
New Approach to the Synthesis of Triazolyl Purine Nucleosides
A straightforward way to synthesis of 2,6-bis-(1,2,3-triazol-1-yl)-purine nucleosides has been developed from 2,6-diazidopurine nucleosides and various terminal alkynes.
Bārzdaine, Madara +4 more
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Chemistry – A European Journal, EarlyView.A double‐headed bis‐guanine (G) nucleotide (GG) was evaluated as a noncanonical building block in G‐quadruplexes (G4s). Biophysical and computational analyses reveal that GG can directly participate in G‐tetrads and strongly stabilize G4s in a position‐ and topology‐dependent manner. These findings establish design rules for using GG to engineer highly
Krista Urup +5 more
wiley +1 more source
Synthesis and Properties of Triazolyl Purine Nucleosides
A novel class of bis-triazolyl purine nucleosides was obtained and triazolyl moiety at C(6) of the purine base undergoes a facile nucleophilic heteroaromatic substitution with N- and S-nucleophiles.
Novosjolova, Irina
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Multivalent RNA‐Cleaving Agents on a Cubic Octameric Silsesquioxane Core
Chemistry – A European Journal, EarlyView.RNA‐cleaving agents on a cubic octameric silsesquioxane core were synthesized and characterized. Several catalytic systems of these structures were screened using hexaribonucleotide models. The best systems were then further used to study their catalytic efficiency in cleaving a HER2 mRNA model sequence. The induced cleavage sites were also determined.
Hanni Haapsaari, Iris Tuomi, Pasi Virta
wiley +1 more source
THE ROLE OF NUCLEOTIDE SUBSTANSES AND NO-SYNTHASE IN THE IMMUNE PROTECTION OF THE ORGANISM
Разработка и регистрация лекарственных средств, 2019 The present article describes the biochemical mechanisms and the possibility of nucleotides and nucleosides substances naturally produced (i.e. Saccharomyces cerevisiae and others) medicine application in field of correction of pathologically altered ...
V. S. Orlova +3 more
doaj
Quantum chemical and molecular modeling studies of twenty therapeutic nucleosides and nucleoside analogues [PDF]
Naturally occurring and synthetic, chemically modified nucleosides and nucleoside analogues are suggested to be effective therapeutic agents against different diseases, especially viral diseases, and cancer.
Ansuman, Lahiri +3 more
core +2 more sources
Chemistry – A European Journal, EarlyView.A set of new phosphonomethyl (thio)phosphonamidite reagents is introduced to generate unprecedented pyrophosphate mimetics. The versatile P(III)‐P(V) reagents allow for the construction of various pyrophosphate isosteres, and the applicability of the chemistry is illustrated in the assembly of a diverse set of stabilized CDP‐glycerol and CDP‐ribitol ...
Pascal Balić +4 more
wiley +1 more source
Uncatalyzed Guanosine Phosphorylation under Potentially Prebiotic Conditions
Chemistry – A European Journal, EarlyView.Pyrophosphate acts as phosphorylating agent of guanosine under simple wet‐dry cycles without condensing agent and inorganic catalysts to afford cyclic guanosine monophosphate derivatives useful for oligomerization in prebiotic processes. ABSTRACT The phosphorylation of nucleosides and their subsequent polymerization are key issues in the study of the ...
Martina Proietti +5 more
wiley +1 more source
Triazolylpurine Nucleosides: Synthetic Approaches and Biological Activity
A novel method for the synthesis of C(2) and C(6) modified purine nucleoside analogues has been developed. The obtained triazolyl purine nucleosides were tested for their activity against Chikungunya virus, murine Norovirus, enterovirus 71 and yellow ...
Leyssen, Pieter +4 more
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