Results 211 to 220 of about 193,772 (411)

A Randomized Phase 1 Study Evaluating Pharmacokinetics, Safety, and Tolerability of a High‐Concentration, Long‐Acting Cabotegravir Formulation in Adults Without HIV

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Long‐acting (LA) cabotegravir 200‐mg/mL (CAB200) injections are approved for HIV‐1 prevention and as a complete LA HIV‐1 treatment regimen with rilpivirine. A high‐concentration suspension formulation, cabotegravir 400 mg/mL (CAB400‐D), was developed to enable less frequent dosing and self‐administration. This phase 1, double‐blind, randomized
Kelong Han, Paul Benn, Jörg Sievers, David Dorey, Michael Warwick‐Sanders, Randa Hareedy, Louise Harkness, Claudia Leemereise, Kjersten Offenbecker, Christina Donatti, Darin B. Brimhall, Christian Schwabe, Craig Boyle, Michael A. Hassman, Steve Knowles, Ronald D'Amico, William R. Spreen   +16 more
wiley   +1 more source

MUTATIONS INDUCED IN ARABIDOPSIS BY DNA NUCLEOSIDE ANALOGS [PDF]

, 1969
Yoko Hirono, Harold H. Smith
openalex   +1 more source

Clinical Evaluation of Potential Interaction Between Bemnifosbuvir and Ruzasvir With an Assessment of Food Effect: Results of a Phase 1 Study in Healthy Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A combination of nucleotide hepatitis C virus (HCV) nonstructural protein (NS) 5B and 5A inhibitors is a preferred standard of care for treating chronic HCV. Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against HCV NS5B.
Xiao‐Jian Zhou, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Arantxa Horga, Janet Hammond   +7 more
wiley   +1 more source

HR-MS Analysis of the Covalent Binding of Edaravone to 5-Formylpyrimidine Bases and a DNA Oligonucleotide Containing a 5-Formylcytidine Residue. [PDF]

Rapid Commun Mass Spectrom
Regnault R, Kouach M, Goossens L, Thuru X, Bailly C, Goossens JF.   +5 more
europepmc   +1 more source

A Novel Method for the Synthesis of Purine Nucleosides using Friedel-Crafts Catalysts

, 1968
Yoshiyasu Furukawa, Mikio Honjo
openalex   +2 more sources

Advances in Isotope Labeling for Solution Nucleic Acid Nuclear Magnetic Resonance Spectroscopy

ChemPlusChem, EarlyView.
Recent advances in the field of nucleic acid nuclear magnetic resonance (NMR) are presented. Stable isotope labeling protocols and new approaches to segmentally label nucleic acid with NMR‐active residues are summarized. The novel methods will have a strong impact on the future of nucleic acid NMR and the characterization of structure and dynamics of ...
Stefan Hilber, Solomon Kojo Attionu, Theodore Kwaku Dayie, Christoph Kreutz   +3 more
wiley   +1 more source

5'-Guanidino Xylofuranosyl Nucleosides as Novel Types of 5'-Functionalized Nucleosides with Biological Potential. [PDF]

Pharmaceuticals (Basel)
Szilagyi J, Moreira T, Nunes RS, Silva J, Alves C, Martins A, Alvariño R, Heise NV, Csuk R, Xavier NM.   +9 more
europepmc   +1 more source

Microbial transformation of nucleosides [PDF]

A study involving the use of coulter counter in studying the effects of neomycin on E. coli, S. aureus and A. aerogenes was completed. The purpose of this was to establish proper technique for enumeration of cells per ml.
Lamba, S. S.
core   +1 more source

STUDIES ON THE PRODUCTION OF NUCLEOSIDES BY MICROORGANISMS

, 1965
Akio Yamanoi, Yoshiteru Hirose, Mikio Aoki, Teruo SHIRO   +3 more
openalex   +2 more sources

Evidence of the Presence of 1-Phosphohistidine as the Main Phosphorylated Component at the Active Site of Bovine Liver Nucleoside Diphosphate Kinase. [PDF]

, 1969
Olov Wålinder, Erik von Sydow, Thomas Popoff, Olof Theander, Alf A. Lindberg, Gert Jansen, Bo Lamm, Benny Samuelsson   +7 more
openalex   +1 more source